STRINGSTRING
sirt6 sirt6 wdtc1 wdtc1 prmt3 prmt3 tspo tspo ep300 ep300 cry1 cry1 c1qtnf9b c1qtnf9b pibf1 pibf1 adipoq adipoq sirt4 sirt4 c1qtnf12 c1qtnf12 stat3.1 stat3.1 LOC101730705 LOC101730705 etfbkmt etfbkmt snai2 snai2 pdzd3 pdzd3 clk3-2 clk3-2 appl2 appl2 ppara ppara acmsd acmsd parp1 parp1 SOGA1 SOGA1 cry4 cry4 stat3.2 stat3.2 pid1 pid1 sox9 sox9 RD3 RD3 flcn flcn plek plek LOC100495217 LOC100495217 brca1 brca1 fgf19 fgf19 ENSXETP00000034825 ENSXETP00000034825 LOC100488346 LOC100488346 tigar tigar snai1 snai1 tp53 tp53 cry-dash cry-dash REST REST SLC27A4 SLC27A4 fam3a fam3a lepr lepr erfe erfe dkk3 dkk3 sirt1 sirt1 fam3c fam3c MST1 MST1 atcay atcay
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
sirt6Sirtuin (Silent mating type information regulation 2 homolog) 6. (331 aa)
wdtc1Transmembrane protein 178, gene 2. (671 aa)
prmt3SMG1 phosphatidylinositol 3-kinase-related kinase; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (523 aa)
tspoDLC1 Rho GTPase activating protein. (243 aa)
ep300Suv3 like RNA helicase. (2493 aa)
cry1Forkhead box protein F1. (616 aa)
c1qtnf9bHECT domain containing E3 ubiquitin protein ligase 3. (244 aa)
pibf1Uncharacterized protein. (755 aa)
adipoqCollagen, type VII, alpha 1 (Epidermolysis bullosa, dystrophic, dominant and recessive). (235 aa)
sirt4NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily. (322 aa)
c1qtnf12Adipolin; Insulin-sensitizing adipocyte-secreted protein (adipokine) that regulates glucose metabolism in liver and adipose tissue. (324 aa)
stat3.1Signal transducer and activator of transcription. (715 aa)
LOC101730705PARP-type domain-containing protein. (102 aa)
etfbkmtUncharacterized protein. (247 aa)
snai2Snail homolog 2 (Drosophila). (266 aa)
pdzd3STARD3 N-terminal like. (428 aa)
clk3-2CDC like kinase 3. (159 aa)
appl2Alveolar soft part sarcoma chromosome region, candidate 1. (664 aa)
pparaLysosomal-associated membrane protein 1. (474 aa)
acmsd2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). Belongs to the metallo-dependent hydrolases superfamily. (336 aa)
parp1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa)
SOGA1Suppressor of glucose, autophagy associated 1. (1617 aa)
cry4WD repeat containing, antisense to TP73. (567 aa)
stat3.2STAT_int domain-containing protein. (408 aa)
pid1IlvB (bacterial acetolactate synthase)-like. (222 aa)
sox9Transcription factor Sox-9; Transcription activator. Acts early in neural crest formation, functioning redundantly with the other group E Sox factors sox8 and sox10 to induce neural crest progenitors. Induces sox10 expression downstream of wnt-signaling. Principally involved in development of the cranial neural crest, which is fated to form skeletal elements. Also required for otic placode specification during inner ear development (By similarity). May be involved in chondrogenesis (cartilage development) during bone formation. Unlikely to play a role in sex determination but may funct [...] (482 aa)
RD3Retinal degeneration 3, GUCY2D regulator. (217 aa)
flcnFolliculin; Belongs to the folliculin family. (579 aa)
plekPleckstrin. (350 aa)
LOC100495217UTP14A, small subunit processome component. (263 aa)
brca1Leucine rich repeat containing 18. (1655 aa)
fgf19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (215 aa)
ENSXETP00000034825Uncharacterized protein. (666 aa)
LOC100488346Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1239 aa)
tigarFructose-2,6-bisphosphatase TIGAR; Fructose-bisphosphatase hydrolyzing fructose-2,6-bisphosphate as well as fructose-1,6-bisphosphate. Acts as a negative regulator of glycolysis by lowering intracellular levels of fructose-2,6- bisphosphate in a p53/TP53-dependent manner, resulting in the pentose phosphate pathway (PPP) activation and NADPH production. Contributes to the generation of reduced glutathione to cause a decrease in intracellular reactive oxygen species (ROS) content, correlating with its ability to protect cells from oxidative or metabolic stress-induced cell death. May pla [...] (554 aa)
snai1Uncharacterized protein. (336 aa)
tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (362 aa)
cry-dashFamily with sequence similarity 92 member B. (445 aa)
RESTRE1 silencing transcription factor. (1442 aa)
SLC27A4Solute carrier family 27 member 4. (643 aa)
fam3aFamily with sequence similarity 3, member A. (230 aa)
leprLeucine-rich repeat-containing protein 42. (1138 aa)
erfeClustered mitochondria protein homolog. (311 aa)
dkk3Ankyrin repeat and SOCS box containing 4. (336 aa)
sirt1Thrombospondin-type laminin G domain and EAR repeats. (707 aa)
fam3cProtein FAM3C; Involved in retinal laminar formation; Belongs to the FAM3 family. (229 aa)
MST1Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. (718 aa)
atcaySuccinate dehydrogenase complex assembly factor 4. (398 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
Server load: medium (46%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.