node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APAF1 | BCL2 | ENSXETP00000049692 | ENSXETP00000032076 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | BCL2 apoptosis regulator. | 0.898 |
APAF1 | ENSXETP00000051440 | ENSXETP00000049692 | ENSXETP00000051440 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Uncharacterized protein. | 0.567 |
APAF1 | aifm1 | ENSXETP00000049692 | ENSXETP00000032430 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. | 0.543 |
APAF1 | bax | ENSXETP00000049692 | ENSXETP00000009494 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | BCL2-associated X protein. | 0.752 |
APAF1 | tp53 | ENSXETP00000049692 | ENSXETP00000041856 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.588 |
BCL2 | APAF1 | ENSXETP00000032076 | ENSXETP00000049692 | BCL2 apoptosis regulator. | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | 0.898 |
BCL2 | ENSXETP00000051440 | ENSXETP00000032076 | ENSXETP00000051440 | BCL2 apoptosis regulator. | Uncharacterized protein. | 0.839 |
BCL2 | bax | ENSXETP00000032076 | ENSXETP00000009494 | BCL2 apoptosis regulator. | BCL2-associated X protein. | 0.997 |
BCL2 | ddit3 | ENSXETP00000032076 | ENSXETP00000001396 | BCL2 apoptosis regulator. | Potassium channel, voltage gated subfamily E regulatory beta subunit 3. | 0.937 |
BCL2 | tp53 | ENSXETP00000032076 | ENSXETP00000041856 | BCL2 apoptosis regulator. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.924 |
ENSXETP00000051440 | APAF1 | ENSXETP00000051440 | ENSXETP00000049692 | Uncharacterized protein. | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | 0.567 |
ENSXETP00000051440 | BCL2 | ENSXETP00000051440 | ENSXETP00000032076 | Uncharacterized protein. | BCL2 apoptosis regulator. | 0.839 |
ENSXETP00000051440 | bax | ENSXETP00000051440 | ENSXETP00000009494 | Uncharacterized protein. | BCL2-associated X protein. | 0.751 |
ENSXETP00000051440 | tp53 | ENSXETP00000051440 | ENSXETP00000041856 | Uncharacterized protein. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.746 |
aifm1 | APAF1 | ENSXETP00000032430 | ENSXETP00000049692 | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | 0.543 |
atf4 | cebpb | ENSXETP00000018298 | ENSXETP00000038854 | Activating transcription factor 4 (Tax-responsive enhancer element B67). | CCAAT/enhancer binding protein (C/EBP), beta. | 0.872 |
atf4 | chac1 | ENSXETP00000018298 | ENSXETP00000053791 | Activating transcription factor 4 (Tax-responsive enhancer element B67). | Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family. | 0.637 |
atf4 | ddit3 | ENSXETP00000018298 | ENSXETP00000001396 | Activating transcription factor 4 (Tax-responsive enhancer element B67). | Potassium channel, voltage gated subfamily E regulatory beta subunit 3. | 0.970 |
atf4 | ern2 | ENSXETP00000018298 | ENSXETP00000023427 | Activating transcription factor 4 (Tax-responsive enhancer element B67). | Endoplasmic reticulum to nucleus signaling 2. | 0.538 |
bax | APAF1 | ENSXETP00000009494 | ENSXETP00000049692 | BCL2-associated X protein. | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | 0.752 |