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atf4 atf4 rnf186 rnf186 bag6 bag6 pdx1 pdx1 bax bax atp2a3 atp2a3 rad18-2 rad18-2 tmem117 tmem117 ddit3 ddit3 chac1 chac1 ENSXETP00000051440 ENSXETP00000051440 APAF1 APAF1 qrich1 qrich1 tp53 tp53 cebpb cebpb aifm1 aifm1 BCL2 BCL2 ern2 ern2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
atf4Activating transcription factor 4 (Tax-responsive enhancer element B67). (343 aa)
rnf186RING-type domain-containing protein. (247 aa)
bag6Large proline-rich protein bag6; ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins. Functions as part of a cytosolic protein quality control complex, the bag6/bat3 complex, which maintains these client proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The bag6/bat3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endo [...] (1135 aa)
pdx1Hepatocyte nuclear factor 4, beta. (271 aa)
baxBCL2-associated X protein. (221 aa)
atp2a3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1037 aa)
rad18-2Uncharacterized protein. (381 aa)
tmem117Uncharacterized protein. (191 aa)
ddit3Potassium channel, voltage gated subfamily E regulatory beta subunit 3. (209 aa)
chac1Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family. (218 aa)
ENSXETP00000051440Uncharacterized protein. (168 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa)
qrich1Glutamine-rich 1. (799 aa)
tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (362 aa)
cebpbCCAAT/enhancer binding protein (C/EBP), beta. (145 aa)
aifm1Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. (648 aa)
BCL2BCL2 apoptosis regulator. (293 aa)
ern2Endoplasmic reticulum to nucleus signaling 2. (957 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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