(14 nodes) I-SMAD binding network (Xenopus tropicalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Smad6.2	MH2 domain-containing protein. (206 aa)
	smad1	Mothers against decapentaplegic homolog. (464 aa)
	ctnnb1	Dynactin subunit 5. (788 aa)
	tgfbr1	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa)
	smad4.1	Mothers against decapentaplegic homolog. (579 aa)
	axin1	P21 protein (Cdc42/Rac)-activated kinase 3. (877 aa)
	cep112	Adenosine monophosphate deaminase 2. (310 aa)
	smurf1	E3 ubiquitin-protein ligase. (748 aa)
	SMAD7	Mothers against decapentaplegic homolog. (382 aa)
	smad3	Mothers against decapentaplegic homolog. (461 aa)
	SMAD6	Mothers against decapentaplegic homolog. (352 aa)
	smad2	Mothers against decapentaplegic homolog. (467 aa)
	ints8	Large tumor suppressor kinase 2. (998 aa)
	smad9	Mothers against decapentaplegic homolog. (466 aa)

Your Current Organism:

Xenopus tropicalis

NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SMAD6	SMAD7	ENSXETP00000007537	ENSXETP00000007713	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.942
SMAD6	Smad6.2	ENSXETP00000007537	ENSXETP00000025048	Mothers against decapentaplegic homolog.	MH2 domain-containing protein.	0.901
SMAD6	smad1	ENSXETP00000007537	ENSXETP00000044125	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.964
SMAD6	smad2	ENSXETP00000007537	ENSXETP00000007218	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.926
SMAD6	smad4.1	ENSXETP00000007537	ENSXETP00000033001	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.740
SMAD6	smad9	ENSXETP00000007537	ENSXETP00000002189	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.934
SMAD6	smurf1	ENSXETP00000007537	ENSXETP00000016722	Mothers against decapentaplegic homolog.	E3 ubiquitin-protein ligase.	0.991
SMAD6	tgfbr1	ENSXETP00000007537	ENSXETP00000038795	Mothers against decapentaplegic homolog.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.730
SMAD7	SMAD6	ENSXETP00000007713	ENSXETP00000007537	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.942
SMAD7	Smad6.2	ENSXETP00000007713	ENSXETP00000025048	Mothers against decapentaplegic homolog.	MH2 domain-containing protein.	0.900
SMAD7	ctnnb1	ENSXETP00000007713	ENSXETP00000043290	Mothers against decapentaplegic homolog.	Dynactin subunit 5.	0.641
SMAD7	smad1	ENSXETP00000007713	ENSXETP00000044125	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.925
SMAD7	smad2	ENSXETP00000007713	ENSXETP00000007218	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.933
SMAD7	smad4.1	ENSXETP00000007713	ENSXETP00000033001	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.722
SMAD7	smad9	ENSXETP00000007713	ENSXETP00000002189	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.930
SMAD7	smurf1	ENSXETP00000007713	ENSXETP00000016722	Mothers against decapentaplegic homolog.	E3 ubiquitin-protein ligase.	0.996
SMAD7	tgfbr1	ENSXETP00000007713	ENSXETP00000038795	Mothers against decapentaplegic homolog.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.970
Smad6.2	SMAD6	ENSXETP00000025048	ENSXETP00000007537	MH2 domain-containing protein.	Mothers against decapentaplegic homolog.	0.901
Smad6.2	SMAD7	ENSXETP00000025048	ENSXETP00000007713	MH2 domain-containing protein.	Mothers against decapentaplegic homolog.	0.900
Smad6.2	smad1	ENSXETP00000025048	ENSXETP00000044125	MH2 domain-containing protein.	Mothers against decapentaplegic homolog.	0.919

page 1 of 5

Server load: low (14%) [HD]

Permalink

Network

Fusion

Experiments

Cooccurrence

Databases

Coexpression

Textmining

Neighborhood

© STRING Consortium 2025

Credits

Access

Info

About