STRINGSTRING
avpr2.2-2 avpr2.2-2 eef2k eef2k bub1b-2 bub1b-2 GUCY1B1 GUCY1B1 edn1 edn1 arnt arnt TH TH OPRD1 OPRD1 ep300 ep300 stox1 stox1 mdm4 mdm4 ptgs2 ptgs2 loxl4 loxl4 txn2 txn2 has1-2 has1-2 ndnfl1.1 ndnfl1.1 DDR2 DDR2 pdk3 pdk3 FNDC1 FNDC1 fas fas gucy1b2 gucy1b2 rbpj rbpj TGFB2 TGFB2 ado ado VEGFD VEGFD hipk2-2 hipk2-2 foxo3 foxo3 mgarp mgarp mecp2 mecp2 pin1 pin1 xrcc1 xrcc1 hif1an hif1an VEGFC VEGFC ngb ngb ddr2l ddr2l LOC733765 LOC733765 atp6v1a atp6v1a TM9SF4 TM9SF4 bach1 bach1 srf srf atf4 atf4 NF1 NF1 ndufs2 ndufs2 gucy1a1 gucy1a1 nop53 nop53 atp6v1g1 atp6v1g1 th2 th2 rgcc rgcc hyou1 hyou1 vegfa vegfa fundc1 fundc1 tert tert cygb cygb cpeb1 cpeb1 alkbh5 alkbh5 egln2 egln2 limd1 limd1 SIRT2 SIRT2 tbl2 tbl2 CPEB2 CPEB2 hsp90b1 hsp90b1 atp6ap1.2 atp6ap1.2 plekhn1 plekhn1 tsc1 tsc1 slc9a1 slc9a1 hmox1 hmox1 epo epo foxo1 foxo1 KCNK2 KCNK2 chrna7 chrna7 BCL2 BCL2 aifm1 aifm1 mtor mtor smad4.1 smad4.1 p2rx2 p2rx2 cuzd1.2 cuzd1.2 ccdc115 ccdc115 cryab cryab vegfb vegfb bad bad LONP1 LONP1 fabp1 fabp1 bnip1 bnip1 pick1-2 pick1-2 adam17 adam17 LOC100496423 LOC100496423 cav3.2 cav3.2 ddit4 ddit4 epas1 epas1 tp53 tp53 gucy1a2 gucy1a2 Hif1a Hif1a txnrd2 txnrd2 bnip3 bnip3 pam pam plat plat scap scap ednra ednra polb polb REST REST slc7a5 slc7a5 narf narf AK4 AK4 cav3.1 cav3.1 vhl vhl myocd myocd ENSXETP00000047944 ENSXETP00000047944 cav1 cav1 nkx3-1 nkx3-1 sirt1 sirt1 loxl2 loxl2 npepps npepps egln1 egln1 gata6 gata6 arnt2 arnt2 nfe2l2 nfe2l2 LOC100487454 LOC100487454 scfd1 scfd1 dpp4 dpp4 egln3 egln3 myc myc
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
avpr2.2-2Arginine vasopressin receptor 2 (nephrogenic diabetes insipidus), gene 2. (508 aa)
eef2kNeuraminidase 4 (sialidase). (777 aa)
bub1b-2Chloride channel accessory 2. (496 aa)
GUCY1B1Guanylate cyclase 1 soluble subunit beta 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (636 aa)
edn1Nidogen 2. (222 aa)
arntRas homolog, mTORC1 binding. (778 aa)
THTyrosine hydroxylase. (478 aa)
OPRD1Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family. (383 aa)
ep300Suv3 like RNA helicase. (2493 aa)
stox1Disks large homolog 1. (977 aa)
mdm4Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (474 aa)
ptgs2EGF-like domain-containing protein. (619 aa)
loxl4Cell division cycle 5 like. (731 aa)
txn2TNF superfamily member 13b. (170 aa)
has1-2Cleavage and polyadenylation specific factor 7. (431 aa)
ndnfl1.1Uncharacterized protein. (546 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (856 aa)
pdk3Protein-serine/threonine kinase. (430 aa)
FNDC1Uncharacterized protein. (1396 aa)
fasVitamin D receptor. (320 aa)
gucy1b2Ankyrin 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (615 aa)
rbpjUbiquinol-cytochrome c reductase core protein 2. (464 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (418 aa)
adoComponent of oligomeric golgi complex 4. (266 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (333 aa)
hipk2-2Homeodomain interacting protein kinase 2. (434 aa)
foxo3Foxo3 protein. (653 aa)
mgarpAIF-MLS domain-containing protein. (560 aa)
mecp2Kruppel-like factor 17. (466 aa)
pin1Peptidyl-prolyl cis-trans isomerase. (159 aa)
xrcc1Uncharacterized protein. (632 aa)
hif1anHypoxia-inducible factor 1, alpha subunit inhibitor. (352 aa)
VEGFCVascular endothelial growth factor C. (407 aa)
ngbMMS22 like, DNA repair protein; Belongs to the globin family. (164 aa)
ddr2lDiscoidin domain receptor family, member 2. (879 aa)
LOC733765Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (141 aa)
atp6v1aGlypican 5. (596 aa)
TM9SF4Transmembrane 9 superfamily member; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. (487 aa)
bach1Succinate dehydrogenase complex subunit C. (731 aa)
srfHydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7. (359 aa)
atf4Activating transcription factor 4 (Tax-responsive enhancer element B67). (343 aa)
NF1Neurofibromin 1. (2812 aa)
ndufs2Beta-1,3-glucuronyltransferase 3; Belongs to the complex I 49 kDa subunit family. (478 aa)
gucy1a1Alpha-T4 globin, Putative ortholog of hemoglobin alpha chain; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (664 aa)
nop53Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (452 aa)
atp6v1g1V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
th2Uncharacterized protein. (434 aa)
rgccDual specificity phosphatase 11 (RNA/RNP complex 1-interacting), gene 2. (128 aa)
hyou1Hypoxia up-regulated protein 1; Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding; Belongs to the heat shock protein 70 family. (1016 aa)
vegfaGID complex subunit 8; Belongs to the PDGF/VEGF growth factor family. (311 aa)
fundc1FUN14 domain-containing protein 1; Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control; Belongs to the FUN14 family. (181 aa)
tertTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (1196 aa)
cygbCytoglobin; Belongs to the globin family. (179 aa)
cpeb1Uncharacterized protein. (564 aa)
alkbh5RNA demethylase ALKBH5; Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Can also demethylate N(6)-methyladenosine in single- stranded DNA (in vitro) (By similarity). Requires molecular oxygen, alpha-ketoglutarate and iron (By similarity). Demethylation of m6A mRNA affects mRNA processing and export (By similarity). (358 aa)
egln2T-box protein VegT. (454 aa)
limd1LIM domain-containing protein 1; Acts as a transcriptional corepressor for snai1 and snai2/slug and plays a role in regulating neural crest development. (589 aa)
SIRT2NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (414 aa)
tbl2C-X-C motif chemokine receptor 5. (436 aa)
CPEB2Cytoplasmic polyadenylation element binding protein 2. (818 aa)
hsp90b1Heat shock protein 90kDa beta (Grp94), member 1. (803 aa)
atp6ap1.2Uncharacterized protein. (462 aa)
plekhn1Ceramide synthase 2. (724 aa)
tsc1Distal-less homeobox 1. (1139 aa)
slc9a1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (792 aa)
hmox1Transglutaminase 5. (288 aa)
epoEstrogen related receptor alpha. (183 aa)
foxo1Forkhead box protein O1; Transcription factor. (626 aa)
KCNK2Potassium two pore domain channel subfamily K member 2. (347 aa)
chrna7Uncharacterized protein. (504 aa)
BCL2BCL2 apoptosis regulator. (293 aa)
aifm1Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. (648 aa)
mtorSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2534 aa)
smad4.1Mothers against decapentaplegic homolog. (579 aa)
p2rx2P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (357 aa)
cuzd1.2Myogenic factor. (508 aa)
ccdc115Uncharacterized protein. (198 aa)
cryabMitochondrial ribosomal protein L23; Belongs to the small heat shock protein (HSP20) family. (173 aa)
vegfbBradykinin receptor B2. (251 aa)
badSMC5-SMC6 complex localization factor 1. (151 aa)
LONP1Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family. (980 aa)
fabp1DEAH-box helicase 9. (153 aa)
bnip1BCL2/adenovirus E1B 19kD interacting protein 1. (227 aa)
pick1-2Uncharacterized protein. (421 aa)
adam17Monooxygenase, DBH-like 2, pseudogene. (834 aa)
LOC100496423Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (164 aa)
cav3.2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (153 aa)
ddit4DNA damage-inducible transcript 4 protein; Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves ddit4/redd1, akt1, the tsc1-tsc2 complex and the GTPase rheb. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage, via its effect on mTORC1 activity. Plays a role in neuronal differentiation, neuron migration during embryonic brain development and in neuronal cell death (B [...] (219 aa)
epas1Uncharacterized protein. (873 aa)
tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (362 aa)
gucy1a2LOC100145454 protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (712 aa)
Hif1aKIAA1211. (830 aa)
txnrd2Dipeptidase 1; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (515 aa)
bnip3BCL2/adenovirus E1B 19kDa interacting protein 3. (202 aa)
pamUncharacterized protein. (985 aa)
platPlasminogen activator; Belongs to the peptidase S1 family. (560 aa)
scapLOC100145201 protein. (1319 aa)
ednraEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (414 aa)
polbDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (334 aa)
RESTRE1 silencing transcription factor. (1442 aa)
slc7a5Dolichyl-phosphate mannosyltransferase polypeptide 3. (511 aa)
narfTAP binding protein (tapasin); Belongs to the NARF family. (486 aa)
AK4Adenylate kinase 4, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity. (231 aa)
cav3.1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (155 aa)
vhlVon Hippel-Lindau tumor suppressor. (167 aa)
myocdYip1 domain family member 1. (956 aa)
ENSXETP00000047944Uncharacterized protein. (497 aa)
cav1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (180 aa)
nkx3-1Homeobox domain-containing protein. (211 aa)
sirt1Thrombospondin-type laminin G domain and EAR repeats. (707 aa)
loxl2Lysyl oxidase homolog 2; Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). Acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Shows no activity against histone H3 when it is trimethylated on 'Lys- 9' (H3K9me3) or 'Lys-27' (H3K27me3) or when 'Lys-4' is monomethylated (H3K4me1) or dimethylated (H3K4me2). Also mediates deamination of methylated TAF10, a member o [...] (786 aa)
npeppsAminopeptidase. (971 aa)
egln1EGL nine homolog 2 (C. elegans). (394 aa)
gata6Zinc-finger transcription factor Gata6. (524 aa)
arnt2Uncharacterized protein. (730 aa)
nfe2l2Similar to nfe2l2 (Nuclear factor (Erythroid-derived 2)-like 2). (589 aa)
LOC100487454Uncharacterized protein. (454 aa)
scfd1Interleukin 17B; Belongs to the STXBP/unc-18/SEC1 family. (635 aa)
dpp4Uncharacterized protein; Belongs to the peptidase S9B family. (837 aa)
egln3Protein phosphatase, Mg2+/Mn2+ dependent 1A. (252 aa)
mycTranscriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (418 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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