Your Input: | |
| | usp18 | USP domain-containing protein; Belongs to the peptidase C19 family. (363 aa) |
| | septin2-2 | Septin 2. (1118 aa) |
| | cops4 | Hematopoietically-expressed homeobox protein hhex. (417 aa) |
| | mindy4 | Probable ubiquitin carboxyl-terminal hydrolase MINDY-4; Probable hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins; Belongs to the MINDY deubiquitinase family. FAM188 subfamily. (746 aa) |
| | otulinl | Methylcytosine dioxygenase tet3. (290 aa) |
| | krt18.1 | Keratin, type I cytoskeletal 18; When phosphorylated, plays a role in filament reorganization. (429 aa) |
| | otud3 | H2A histone family member V. (407 aa) |
| | cpm-2 | Carboxypeptidase M. (1325 aa) |
| | LOC101730522 | ULP_PROTEASE domain-containing protein. (401 aa) |
| | wdr48 | WD repeat-containing protein 48; Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 and USP46. Enhances the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself. Also activates deubiquitinating activity of complexes containing USP12. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. May play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes. (709 aa) |
| | taf4 | Centrin 4. (1045 aa) |
| | supt3h | Uncharacterized protein. (414 aa) |
| | usp5 | Ubiquitin carboxyl-terminal hydrolase. (855 aa) |
| | usp10 | Ubiquitin carboxyl-terminal hydrolase 10; Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/tp53. Acts as an essential regulator of p53/tp53 stability: in unstressed cells, specifically deubiquitinates p53/tp53 in the cytoplasm, leading to counteracts MDM2 action and stabilize p53/tp53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/tp53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/tp53 levels (By similarity). (862 aa) |
| | bap1 | Ubiquitin carboxyl-terminal hydrolase BAP1; Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (By similarity); Belongs to the peptidase C12 family. BAP1 subfamily. (700 aa) |
| | usp42 | Ubiquitin carboxyl-terminal hydrolase. (703 aa) |
| | OTUD7B | OTU deubiquitinase 7B. (869 aa) |
| | josd2 | Sec23 homolog B, COPII coat complex component. (184 aa) |
| | usp2 | Ubiquitin carboxyl-terminal hydrolase. (577 aa) |
| | USP54 | Ubiquitin specific peptidase 54. (1591 aa) |
| | otud4 | Suppressor of cancer cell invasion. (1051 aa) |
| | chia | Ubiquitin carboxyl-terminal hydrolase. (693 aa) |
| | cops5 | COP9 signalosome complex subunit 5; Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity. In the complex, it probably acts as the catalytic center that mediates the cleavage of nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex; Belon [...] (356 aa) |
| | ncln-2 | Nicalin. (1381 aa) |
| | TAF6 | TATA-box binding protein associated factor 6. (395 aa) |
| | usp13 | Ubiquitin carboxyl-terminal hydrolase 13; Deubiquitinase that mediates deubiquitination of target proteins and is involved in various processes such as autophagy and endoplasmic reticulum-associated degradation (ERAD). (858 aa) |
| | USP12 | Ubiquitin specific peptidase 12; Belongs to the peptidase C19 family. (375 aa) |
| | stambpl1 | Purinergic receptor P2Y, G-protein coupled, 2. (429 aa) |
| | F7AA28_XENTR | Reverse transcriptase domain-containing protein. (996 aa) |
| | sgf29 | Pseudouridine synthase like 1. (269 aa) |
| | mysm1 | Tyrosine kinase 2. (857 aa) |
| | usp15 | Ubiquitin carboxyl-terminal hydrolase 15; Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling and NF-kappa-B pathways. Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs, thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes. According to another reports, regulates the TGF-beta receptor signaling pathway by mediating deubiqu [...] (982 aa) |
| | ENSXETP00000007878 | Reverse transcriptase domain-containing protein. (1326 aa) |
| | usp7 | Synaptophysin; Belongs to the peptidase C19 family. (1131 aa) |
| | LOC101735032 | USP domain-containing protein; Belongs to the peptidase C19 family. (337 aa) |
| | taf5 | Myeloid-associated differentiation marker homolog. (777 aa) |
| | dhx58-2 | Ataxin-7-like protein 3; Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histone H2B. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. (292 aa) |
| | sf3b3 | CPSF_A domain-containing protein. (1217 aa) |
| | LOC101731896 | DUF862 domain-containing protein. (132 aa) |
| | UCHL5 | Ubiquitin carboxyl-terminal hydrolase. (329 aa) |
| | uchl1 | Ubiquitin carboxyl-terminal hydrolase. (286 aa) |
| | USP35 | Ubiquitin carboxyl-terminal hydrolase. (995 aa) |
| | otud6b | Deubiquitinase OTUD6B; Deubiquitinating enzyme that may play a role in the ubiquitin-dependent regulation of different cellular processes. (294 aa) |
| | USP8 | Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family. (1058 aa) |
| | cops2 | MGC97656 protein. (443 aa) |
| | usp32 | Uncharacterized protein; Belongs to the peptidase C19 family. (1643 aa) |
| | psmd14 | Prokineticin receptor 2. (313 aa) |
| | vcpip1 | Ubiquitin C. (1194 aa) |
| | senp8 | LOC100145737 protein. (215 aa) |
| | cops8 | COP9 signalosome complex subunit 8; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity (By similarity). (200 aa) |
| | Zc3h12a | C3H1-type domain-containing protein. (349 aa) |
| | idi1-2 | Isopentenyl-diphosphate delta isomerase 1. (290 aa) |
| | usp40 | Cone-rod homeobox; Belongs to the peptidase C19 family. (1227 aa) |
| | map1lc3a-3 | Microtubule associated protein 1 light chain 3 alpha. (121 aa) |
| | abraxas1 | BRCA1-A complex subunit Abraxas 1; Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of brca1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the brca1-bard1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX [...] (408 aa) |
| | usp3 | Ubiquitinyl hydrolase 1. (529 aa) |
| | ENSXETP00000050419 | Ski_Sno domain-containing protein. (403 aa) |
| | cops6 | COP9 signalosome complex subunit 6; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity (By similarity). (350 aa) |
| | sf3b5 | Splicing factor 3B subunit 5; Belongs to the SF3B5 family. (86 aa) |
| | OTUD1 | OTU deubiquitinase 1. (274 aa) |
| | USP37 | Ubiquitin carboxyl-terminal hydrolase. (976 aa) |
| | stambp | STAM-binding protein. (416 aa) |
| | usp20 | Ubiquitin carboxyl-terminal hydrolase 20; Deubiquitinating enzyme involved in beta-2 adrenergic receptor (adrb2) recycling. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (adrb2). Plays a central role in adrb2 recycling and resensitization after prolonged agonist stimulation by constitutively binding adrb2, mediating deubiquitination of adrb2 and inhibiting lysosomal trafficking of adrb2. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity); Belongs to the pe [...] (932 aa) |
| | cyld | TLR4 interactor with leucine-rich repeats; Belongs to the peptidase C19 family. (975 aa) |
| | usp47 | Ubiquitin carboxyl-terminal hydrolase 47; Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (polb), stabilizing polb thereby playing a role in base-excision repair (BER). (1354 aa) |
| | usp19 | Uncharacterized protein. (1465 aa) |
| | USP4 | Ubiquitin carboxyl-terminal hydrolase. (978 aa) |
| | usp24 | Proteasome subunit beta 6; Belongs to the peptidase C19 family. (2594 aa) |
| | usp25 | USP domain-containing protein; Belongs to the peptidase C19 family. (1157 aa) |
| | tlk2 | Serine/threonine-protein kinase tousled-like 2; Negative regulator of amino acid starvation-induced autophagy. (724 aa) |
| | usp33 | Ubiquitin carboxyl-terminal hydrolase 33; Deubiquitinating enzyme involved in various processes such as centrosome duplication, cellular migration and beta-2 adrenergic receptor/ADRB2 recycling. Involved in regulation of centrosome duplication by mediating deubiquitination of ccp110 in S and G2/M phase, leading to stabilize ccp110 during the period which centrioles duplicate and elongate. Involved in cell migration via its interaction with intracellular domain of robo1, leading to regulate the Slit signaling. Plays a role in commissural axon guidance cross the ventral midline of the ne [...] (904 aa) |
| | usp43 | Solute carrier family 29 (equilibrative nucleoside transporter), member 2; Belongs to the peptidase C19 family. (802 aa) |
| | ATXN7L1 | Ataxin 7 like 1. (902 aa) |
| | usp14 | Ubiquitin carboxyl-terminal hydrolase. (492 aa) |
| | otub2 | Minichromosome maintenance complex component 3. (248 aa) |
| | TAF6L | TATA-box binding protein associated factor 6 like. (574 aa) |
| | usp34 | Queuine tRNA-ribosyltransferase catalytic subunit 1; Belongs to the peptidase C19 family. (3543 aa) |
| | ENSXETP00000044680 | Reverse transcriptase domain-containing protein. (657 aa) |
| | mindy4b | Methyltransferase-like 26. (365 aa) |
| | COPS7B | COP9 signalosome subunit 7B. (264 aa) |
| | usp12b | USP domain-containing protein; Belongs to the peptidase C19 family. (369 aa) |
| | atxn3 | Sorting nexin-30. (356 aa) |
| | uspl1 | Exportin 1. (1929 aa) |
| | OTUD7A | OTU deubiquitinase 7A. (928 aa) |
| | ncoa6-2 | USP domain-containing protein; Belongs to the peptidase C19 family. (2558 aa) |
| | TRRAP | Transformation/transcription domain associated protein; Belongs to the PI3/PI4-kinase family. (3845 aa) |
| | babam1 | BRISC and BRCA1-A complex member 1; Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'- linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Component of the BRISC complex, a multiprotein complex that specifically cl [...] (328 aa) |
| | F7BLJ8_XENTR | Reverse transcriptase domain-containing protein. (730 aa) |
| | scnn1a-2 | Ubiquitin carboxyl-terminal hydrolase. (806 aa) |
| | uimc1 | BRCA1-A complex subunit RAP80; Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the brca1-bard1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquiti [...] (874 aa) |
| | USP31 | Ubiquitin specific peptidase 31; Belongs to the peptidase C19 family. (1248 aa) |
| | camlg-2 | Calcium modulating ligand. (1348 aa) |
| | abraxas2 | BRISC complex subunit Abraxas 2; Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked polyubiquitin, leaving the last ubiquitin chain attached to its substrates. May act as a central scaffold protein that assembles the various components of the BRISC complex and retains them in the cytoplasm (By similarity). Plays a role in regulating the onset of apoptosis via its role in modulating 'Lys- 63'-linked ubiquitination of target proteins (By similarity). Required for normal mitotic spindle assembly and microtubule attachment to kinetochores via i [...] (390 aa) |
| | zranb1 | Ubiquitin thioesterase zranb1; Specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin. Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones. Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. May play a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration (By similarity). (729 aa) |
| | taf5l | Relaxin family peptide receptor 3. (588 aa) |
| | ENSXETP00000039203 | Reverse transcriptase domain-containing protein. (885 aa) |
| | SPATA2 | Spermatogenesis associated 2. (519 aa) |
| | desi2l | DUF862 domain-containing protein. (192 aa) |
| | senp5 | ULP_PROTEASE domain-containing protein. (725 aa) |
| | senp7 | Tetraspanin-9. (863 aa) |
| | usp30 | Ubiquitin carboxyl-terminal hydrolase 30; Deubiquitinating enzyme that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PRKN). (519 aa) |
| | USP38 | Ubiquitin specific peptidase 38; Belongs to the peptidase C19 family. (1034 aa) |
| | usp44 | Ubiquitin carboxyl-terminal hydrolase 44; Deubiquitinase that plays a key role in the spindle checkpoint by preventing premature anaphase onset. Acts by specifically mediating deubiquitination of cdc20, a negative regulator of the anaphase promoting complex/cyclosome (APC/C) (By similarity). (704 aa) |
| | usp39 | Membrane associated guanylate kinase, WW and PDZ domain containing 1. (577 aa) |
| | YOD1 | YOD1 deubiquitinase. (329 aa) |
| | OTUB1 | Ubiquitin thioesterase. (268 aa) |
| | LOC101733270 | Uncharacterized protein. (340 aa) |
| | pgpep1-2 | Pyroglutamyl-peptidase I. (108 aa) |
| | usp16 | Ubiquitin carboxyl-terminal hydrolase 16; Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B. (864 aa) |
| | rpl7l1 | Ribosomal protein L7 like 1; Belongs to the peptidase C19 family. (332 aa) |
| | desi1 | DUF862 domain-containing protein. (205 aa) |
| | usp1 | Ubiquitin carboxyl-terminal hydrolase. (774 aa) |
| | DESI2 | Desumoylating isopeptidase 2. (194 aa) |
| | usp22 | Ubiquitin carboxyl-terminal hydrolase. (572 aa) |
| | brcc3 | Lys-63-specific deubiquitinase BRCC36; Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not have activity toward 'Lys-48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the brca1-bard1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the rnf8-dependent ubiquitination at double- [...] (277 aa) |
| | mindy2 | Mortality factor 4 like 1. (512 aa) |
| | LOC100489307 | Dynein, axonemal, heavy chain 2; Belongs to the peptidase C19 family. (757 aa) |
| | ENSXETP00000028155 | Reverse transcriptase domain-containing protein. (1255 aa) |
| | usp53 | TBC1 domain family member 5. (1018 aa) |
| | TAF2 | TATA-box binding protein associated factor 2. (1191 aa) |
| | ENSXETP00000027220 | USP domain-containing protein. (107 aa) |
| | eif3f | Eukaryotic translation initiation factor 3 subunit F; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (309 aa) |
| | ENSXETP00000025603 | Ubiquitin carboxyl-terminal hydrolase. (384 aa) |
| | atxn7 | SCA7 domain-containing protein. (905 aa) |
| | gps1 | PCI domain-containing protein. (560 aa) |
| | MINDY1 | MINDY lysine 48 deubiquitinase 1. (506 aa) |
| | taf12 | Microtubule associated serine/threonine kinase 1. (218 aa) |
| | txlna-2 | Taxilin alpha. (843 aa) |
| | eny2 | Transcription and mRNA export factor ENY2; Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histones. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. The TREX-2 complex [...] (96 aa) |
| | supt7l | BTP domain-containing protein. (412 aa) |
| | usp48 | Protein tyrosine phosphatase type IVA, member 2; Belongs to the peptidase C19 family. (1039 aa) |
| | usp28 | Rho GTPase activating protein 28; Belongs to the peptidase C19 family. (1104 aa) |
| | usp21 | Kallikrein B1; Belongs to the peptidase C19 family. (511 aa) |
| | josd1 | General transcription factor 2B. (201 aa) |
| | mindy3 | Ubiquitin carboxyl-terminal hydrolase MINDY-3; Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins. (445 aa) |
| | ENSXETP00000021535 | Reverse transcriptase domain-containing protein. (1245 aa) |
| | OTULIN | OTU deubiquitinase with linear linkage specificity. (541 aa) |
