STRINGSTRING
gtf2h4 gtf2h4 rasgef1b rasgef1b ccnh ccnh gtf2h1 gtf2h1 cdk13 cdk13 gtf2h3 gtf2h3 CCNT1 CCNT1 cdk9 cdk9 cdk7 cdk7 supt16h supt16h cdk12 cdk12 ccnk ccnk
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
gtf2h4General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (461 aa)
rasgef1bRas-GEF domain-containing family member 1B; Guanine nucleotide exchange factor (GEF) with specificity for rap2a and other Ras family proteins (in vitro). (547 aa)
ccnhSAFB-like, transcription modulator; Belongs to the cyclin family. (323 aa)
gtf2h1E3 ubiquitin-protein ligase rnf168. (595 aa)
cdk13Ankyrin repeat domain 2 (stretch responsive muscle). (1391 aa)
gtf2h3Uncharacterized protein. (307 aa)
CCNT1CYCLIN domain-containing protein; Belongs to the cyclin family. (631 aa)
cdk9Cyclin-dependent kinase 9; Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor B (P- TEFb), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) and SUPT5H. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. (435 aa)
cdk7Protein kinase domain-containing protein. (381 aa)
supt16hProtein kinase domain-containing protein. (79 aa)
cdk12Cyclin-dependent kinase 12; Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating srsf1/sf2 (By similarity). (1466 aa)
ccnkUncharacterized protein; Belongs to the cyclin family. (659 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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