STRINGSTRING
lig4 lig4 rab11fip5 rab11fip5 cnn1 cnn1 stk11 stk11 bmp6 bmp6 ppid ppid cul4a cul4a LOC100496420 LOC100496420 ep300 ep300 sox1 sox1 noc2l noc2l irf1 irf1 rbmx2-2 rbmx2-2 plpp4-2 plpp4-2 cradd.2 cradd.2 casp10 casp10 casp8 casp8 LOC100488329 LOC100488329 ptgs2 ptgs2 tmem150c tmem150c kdm1a kdm1a KCNK18 KCNK18 bcl10 bcl10 ruvbl2 ruvbl2 trpv4l.3 trpv4l.3 NFATC4 NFATC4 LOC100489056 LOC100489056 xpc xpc pradc1 pradc1 bax bax pbk pbk map3k14 map3k14 opn1sw opn1sw ybx3 ybx3 mmp9.1 mmp9.1 pcna pcna fas fas map3k20 map3k20 cdca7 cdca7 scnn1d scnn1d LOC101730705 LOC101730705 rrh rrh eif2s1 eif2s1 scnn1a scnn1a LOC105946289 LOC105946289 cd40 cd40 trpv3 trpv3 SLC4A11 SLC4A11 blm blm NIPBL NIPBL brca2 brca2 zbtb1 zbtb1 elk1 elk1 pold3 pold3 pold1 pold1 stk39 stk39 opn5.2 opn5.2 opn4 opn4 sfrp2 sfrp2 chek2 chek2 tlr3 tlr3 TP53BP1 TP53BP1 OPN5 OPN5 ercc1 ercc1 rgr rgr tgfb1 tgfb1 parp1 parp1 rad9a rad9a casp2 casp2 fadd fadd xpa xpa TP53INP1 TP53INP1 spidr spidr ovos2-3 ovos2-3 cradd.1 cradd.1 crb1 crb1 mag mag mfap4.1 mfap4.1 grb14-2 grb14-2 rad51d-2 rad51d-2 tmem161a tmem161a cunh9orf116 cunh9orf116 INTS7 INTS7 zmpste24 zmpste24 nucks1 nucks1 cops9 cops9 slc9a1 slc9a1 trpv4l.4 trpv4l.4 epo epo polk polk brca1 brca1 DHX36 DHX36 piezo1 piezo1 MC1R MC1R lrrc8e lrrc8e trpv4l.2 trpv4l.2 ATR ATR trpv4 trpv4 ERCC4 ERCC4 RCSD1 RCSD1 xrcc6 xrcc6 nsmf nsmf rhbdd1 rhbdd1 rad1 rad1 LOC100497753 LOC100497753 mgc69473 mgc69473 otop1-2 otop1-2 mettl3 mettl3 PIEZO2 PIEZO2 tnfrsf1a tnfrsf1a LOC100491668 LOC100491668 errfi1 errfi1 DDB1 DDB1 SMPD1 SMPD1 LOC108645540 LOC108645540 otud6b-2 otud6b-2 trpv1 trpv1 crip1 crip1 cryab cryab bad bad KCNK4 KCNK4 pkd2 pkd2 wrn wrn ptger4 ptger4 hvcn1 hvcn1 RAD9B RAD9B PALM PALM fbxo4 fbxo4 LOC100485437 LOC100485437 LOC100485989 LOC100485989 opn1lw opn1lw LOC100495962 LOC100495962 tlr8 tlr8 cul4b cul4b tlr7 tlr7 ATM ATM actr5 actr5 TNFSF14 TNFSF14 scnn1b scnn1b scnn1g scnn1g tp53 tp53 bnip3 bnip3 gclc gclc ect2 ect2 aurkb aurkb pik3ca pik3ca chek1 chek1 rhno1 rhno1 REST REST WNK3 WNK3 bard1 bard1 itgb3 itgb3 map2k4 map2k4 bdkrb2 bdkrb2 oxsr1 oxsr1 rho rho eif2ak4 eif2ak4 LOC100485206 LOC100485206 sirt1 sirt1 PKD2L1 PKD2L1 MAP3K2 MAP3K2 mapk13 mapk13 ENSXETP00000051440 ENSXETP00000051440 XRCC5 XRCC5 LOC100170560 LOC100170560 lrrc8d lrrc8d lrrc8c lrrc8c map3k1 map3k1 nodal-2 nodal-2 il1b il1b impact impact gnb5 gnb5 ptprk ptprk TANK TANK itgb6 itgb6 ENSXETP00000053506 ENSXETP00000053506 BMF BMF rad51 rad51 INO80 INO80 chp1 chp1 HYAL1 HYAL1 myc myc net1 net1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
lig4DNA ligase. (911 aa)
rab11fip5Uncharacterized protein. (1534 aa)
cnn1Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. (296 aa)
stk11Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (442 aa)
bmp6Enhancer of mRNA decapping 4. (441 aa)
ppidProline-rich nuclear receptor coactivator 2. (370 aa)
cul4aCULLIN_2 domain-containing protein; Belongs to the cullin family. (769 aa)
LOC100496420Metabolism of cobalamin associated D. (345 aa)
ep300Suv3 like RNA helicase. (2493 aa)
sox13-phosphoinositide dependent protein kinase 1. (663 aa)
noc2lPolycomb group ring finger 6. (840 aa)
irf1Interferon regulatory factor. (302 aa)
rbmx2-2RNA binding motif protein X-linked 2. (174 aa)
plpp4-2Phospholipid phosphatase 4. (563 aa)
cradd.2Colony stimulating factor 2 receptor beta common subunit. (197 aa)
casp10Casp10 protein; Belongs to the peptidase C14A family. (519 aa)
casp8S-adenosylmethionine sensor upstream of mTORC1; Belongs to the peptidase C14A family. (504 aa)
LOC100488329Fibrinogen C-terminal domain-containing protein. (259 aa)
ptgs2EGF-like domain-containing protein. (619 aa)
tmem150cRing finger protein 141. (241 aa)
kdm1aLysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (841 aa)
KCNK18Potassium two pore domain channel subfamily K member 18; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (363 aa)
bcl10Solute carrier family 35 (GDP-fucose transporter), member C2. (236 aa)
ruvbl2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (470 aa)
trpv4l.3ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (637 aa)
NFATC4Nuclear factor of activated T cells 4. (1091 aa)
LOC100489056Vertebrate ancient long opsin. (382 aa)
xpcZona pellucida glycoprotein 4, gene 2. (1055 aa)
pradc1Protease-associated domain containing 1. (223 aa)
baxBCL2-associated X protein. (221 aa)
pbkPDZ binding kinase. (325 aa)
map3k14Actin filament associated protein 1. (760 aa)
opn1swOpn1sw protein. (349 aa)
ybx3Cold shock domain protein A. (248 aa)
mmp9.1Uncharacterized protein. (692 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
fasVitamin D receptor. (320 aa)
map3k20Uncharacterized protein. (790 aa)
cdca7Cell division cycle associated 7. (434 aa)
scnn1dCoatomer subunit gamma-2; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (606 aa)
LOC101730705PARP-type domain-containing protein. (102 aa)
rrhCalcium/calmodulin dependent protein kinase (CaM kinase) II delta; Belongs to the G-protein coupled receptor 1 family. (351 aa)
eif2s1Eukaryotic translation initiation factor 2 subunit 1; Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre- initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF- 2 must exchange with GTP by way of a reaction catalyzed [...] (315 aa)
scnn1aClaudin 16; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (632 aa)
LOC105946289Protein kinase domain-containing protein. (307 aa)
cd40CD40. (279 aa)
trpv3Transient receptor potential vanilloid 3; Belongs to the transient receptor (TC 1.A.4) family. (773 aa)
SLC4A11Solute carrier family 4 member 11. (867 aa)
blmUncharacterized protein. (1365 aa)
NIPBLNipped-B protein. (2938 aa)
brca2StAR related lipid transfer domain containing 9. (3138 aa)
zbtb1CCR4-NOT transcription complex subunit 6-like. (685 aa)
elk1Myosin, heavy chain 9, non-muscle. (414 aa)
pold3Ribosomal protein L28. (538 aa)
pold1DNA polymerase. (1191 aa)
stk39Serine threonine kinase 39 (STE20/SPS1 homolog). (526 aa)
opn5.2G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. Opsin subfamily. (353 aa)
opn4MCF.2 cell line derived transforming sequence-like. (531 aa)
sfrp2Secreted frizzled-related protein 2. (295 aa)
chek2GDNF family receptor alpha-like. (504 aa)
tlr3TIR domain-containing protein; Belongs to the Toll-like receptor family. (917 aa)
TP53BP1Tumor protein p53 binding protein 1. (2185 aa)
OPN5Opsin 5; Belongs to the G-protein coupled receptor 1 family. (345 aa)
ercc1Uncharacterized protein. (302 aa)
rgrHes family bHLH transcription factor 5; Belongs to the G-protein coupled receptor 1 family. Opsin subfamily. (295 aa)
tgfb1Transforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
parp1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa)
rad9aCell cycle checkpoint control protein; Belongs to the rad9 family. (379 aa)
casp2BCR, RhoGEF and GTPase activating protein; Belongs to the peptidase C14A family. (421 aa)
faddZinc finger, NFX1-type containing 1, gene 2. (188 aa)
xpaXeroderma pigmentosum, complementation group. (265 aa)
TP53INP1Tumor protein p53 inducible nuclear protein 1. (237 aa)
spidrKiaa0319-like. (924 aa)
ovos2-3Alpha-2-macroglobulin like 1 pseudogene. (2368 aa)
cradd.1CASP2 and RIPK1 domain containing adaptor with death domain. (197 aa)
crb1MSS51 mitochondrial translational activator. (1341 aa)
magPolymerase (DNA directed), epsilon 2, accessory subunit. (657 aa)
mfap4.1Fibrinogen C-terminal domain-containing protein. (254 aa)
grb14-2Growth factor receptor bound protein 14. (238 aa)
rad51d-2RAD51 paralog D. (249 aa)
tmem161aTransmembrane protein 161A; May play a role in protection against oxidative stress. (489 aa)
cunh9orf116Chromosome 9 open reading frame 116. (129 aa)
INTS7Integrator complex subunit 7. (984 aa)
zmpste24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (472 aa)
nucks1Nuclear casein kinase and cyclin-dependent kinase substrate 1. (291 aa)
cops9COP9 signalosome complex subunit 9; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF- type E3 ligase complexes, leading to decrease the Ubl ligase activity. May play a role in cell proliferation. (57 aa)
slc9a1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (792 aa)
trpv4l.4ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (770 aa)
epoEstrogen related receptor alpha. (183 aa)
polkSEC31 homolog A, COPII coat complex component. (865 aa)
brca1Leucine rich repeat containing 18. (1655 aa)
DHX36DEAH-box helicase 36. (1006 aa)
piezo1Piezo-type mechanosensitive ion channel component. (2474 aa)
MC1RMelanocyte-stimulating hormone receptor. (320 aa)
lrrc8eVolume-regulated anion channel subunit LRRC8E; Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. Mediates efflux of amino acids, such as aspartate, in response to osmotic stress. Channel activity requires lrrc8a plus at least one other family member (lrrc8b, lrrc8c, lrrc8d or lrrc8e); channel characteristics depen [...] (806 aa)
trpv4l.2Semaphorin 4D; Belongs to the transient receptor (TC 1.A.4) family. (776 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2608 aa)
trpv4Forkhead box protein D3; Belongs to the transient receptor (TC 1.A.4) family. (868 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (930 aa)
RCSD1RCSD domain containing 1. (328 aa)
xrcc6Ku domain-containing protein. (612 aa)
nsmfProtein KIBRA. (503 aa)
rhbdd1Novel protein containing rhomboid domain. (308 aa)
rad1RAD1 homolog (S. pombe). (281 aa)
LOC100497753Forkhead box E3; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (589 aa)
mgc69473Ion_trans domain-containing protein. (509 aa)
otop1-2Otopetrin 1. (526 aa)
mettl3Lysine (K)-specific demethylase 1B; Belongs to the MT-A70-like family. (573 aa)
PIEZO2Piezo-type mechanosensitive ion channel component. (2774 aa)
tnfrsf1aUncharacterized protein. (413 aa)
LOC100491668Calcium channel, voltage-dependent, gamma subunit 1. (308 aa)
errfi1CD53 molecule. (404 aa)
DDB1Damage specific DNA binding protein 1. (1129 aa)
SMPD1Sphingomyelin phosphodiesterase 1. (511 aa)
LOC108645540Solute carrier family 7 member 8. (385 aa)
otud6b-2Deubiquitinase OTUD6B; Belongs to the G-protein coupled receptor 1 family. (386 aa)
trpv1ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (840 aa)
crip1LIM zinc-binding domain-containing protein. (118 aa)
cryabMitochondrial ribosomal protein L23; Belongs to the small heat shock protein (HSP20) family. (173 aa)
badSMC5-SMC6 complex localization factor 1. (151 aa)
KCNK4Potassium two pore domain channel subfamily K member 4; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (397 aa)
pkd2Ubiquitin carboxyl-terminal hydrolase 33. (951 aa)
wrnCell death-inducing p53-target protein 1. (1432 aa)
ptger4G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (479 aa)
hvcn1Voltage-gated hydrogen channel 1; Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient (By similarity). (230 aa)
RAD9BRAD9 checkpoint clamp component B. (307 aa)
PALMParalemmin. (369 aa)
fbxo4F-box domain-containing protein. (372 aa)
LOC100485437G_PROTEIN_RECEP_F1_2 domain-containing protein. (536 aa)
LOC100485989G_PROTEIN_RECEP_F1_2 domain-containing protein. (362 aa)
opn1lwOpn1lw protein. (365 aa)
LOC100495962TIR domain-containing protein; Belongs to the Toll-like receptor family. (1030 aa)
tlr8Tetratricopeptide repeat domain 21B; Belongs to the Toll-like receptor family. (1036 aa)
cul4bDNL-type zinc finger; Belongs to the cullin family. (872 aa)
tlr7WW domain containing E3 ubiquitin protein ligase 2; Belongs to the Toll-like receptor family. (1054 aa)
ATMNon-specific serine/threonine protein kinase. (3060 aa)
actr5G protein-coupled receptor 84; Belongs to the actin family. (616 aa)
TNFSF14TNF superfamily member 14; Belongs to the tumor necrosis factor family. (171 aa)
scnn1bSodium channel, nonvoltage-gated 1, beta; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (646 aa)
scnn1gCadherin 12, type 2 (N-cadherin 2); Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (675 aa)
tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (362 aa)
bnip3BCL2/adenovirus E1B 19kDa interacting protein 3. (202 aa)
gclcGlutamate-cysteine ligase, catalytic subunit. (637 aa)
ect2Survival of motor neuron 1. (987 aa)
aurkbAurora kinase B; Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Key component of [...] (375 aa)
pik3caPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1067 aa)
chek1Basonuclin 2; Belongs to the protein kinase superfamily. (474 aa)
rhno1Uncharacterized protein. (253 aa)
RESTRE1 silencing transcription factor. (1442 aa)
WNK3Protein kinase domain-containing protein. (1624 aa)
bard1Diaphanous related formin 2. (716 aa)
itgb3Integrin beta; Belongs to the integrin beta chain family. (800 aa)
map2k4Cytosolic carboxypeptidase 2; Belongs to the protein kinase superfamily. (441 aa)
bdkrb26-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2; Belongs to the G-protein coupled receptor 1 family. (371 aa)
oxsr1Homeodomain interacting protein kinase 3. (639 aa)
rhoRhodopsin. (354 aa)
eif2ak4Uncharacterized protein. (1668 aa)
LOC100485206Pannexin_like domain-containing protein. (780 aa)
sirt1Thrombospondin-type laminin G domain and EAR repeats. (707 aa)
PKD2L1Polycystin 2 like 1, transient receptor potential cation channel. (684 aa)
MAP3K2Mitogen-activated protein kinase kinase kinase 2. (630 aa)
mapk13Mitogen-activated protein kinase. (375 aa)
ENSXETP00000051440Uncharacterized protein. (168 aa)
XRCC5X-ray repair cross complementing 5. (767 aa)
LOC100170560LOC100170560 protein. (798 aa)
lrrc8dLOC100145421 protein. (855 aa)
lrrc8cSTT3A, subunit of the oligosaccharyltransferase complex (catalytic). (806 aa)
map3k1Solute carrier family 2 (facilitated glucose transporter), member 1. (1445 aa)
nodal-2Nodal homolog 3-C; Exhibits mesoderm-dorsalizing activity and neural-inducing activity, but lacks mesoderm-inducing activity. Regulates the expression of specific mesodermal and neural genes. Induces convergent extension movements at the embryonic midline by activating the fgf signaling pathway to induce t/bra expression in the organizer region. Acts with wnt11 to induce Spemann organizer cells and induce axis formation (By similarity). The unprocessed protein antagonizes bmp- signaling; Belongs to the TGF-beta family. (403 aa)
il1bInterleukin-1; Belongs to the IL-1 family. (286 aa)
impactProtein IMPACT-A; Translational regulator that ensures constant high levels of translation upon a variety of stress conditions, such as amino acid starvation, UV-C irradiation, proteasome inhibitor treatment and glucose deprivation. Plays a role as a negative regulator of the EIF2AK4/GCN2 kinase activity; impairs GCN1-mediated EIF2AK4/GCN2 activation, and hence EIF2AK4/GCN2-mediated eIF-2-alpha phosphorylation and subsequent down-regulation of protein synthesis. Plays a role in differentiation of neuronal cells by stimulating neurite outgrowth. (364 aa)
gnb5TATA-box binding protein associated factor 13. (395 aa)
ptprkEstrogen related receptor gamma. (1462 aa)
TANKTRAF family member associated NFKB activator. (486 aa)
itgb6Integrin beta; Belongs to the integrin beta chain family. (782 aa)
ENSXETP00000053506NACHT domain-containing protein. (837 aa)
BMFBcl2 modifying factor. (183 aa)
rad51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (336 aa)
INO80INO80 complex ATPase subunit. (1547 aa)
chp1Calcium binding protein P22. (193 aa)
HYAL1Hyaluronidase. (753 aa)
mycTranscriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (418 aa)
net1Uncharacterized protein. (586 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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