(35 nodes) Cellular response to interferon-gamma network (Xenopus tropicalis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	card9-2	Caspase recruitment domain family member 9. (430 aa)
	cdc42ep4	CDC42 effector protein (Rho GTPase binding) 4. (305 aa)
	gbp6	Forkhead box protein I2. (628 aa)
	cand2-2	Proline rich transmembrane protein 1. (633 aa)
	gbp7	Choline/ethanolaminephosphotransferase 1. (608 aa)
	irf1	Interferon regulatory factor. (302 aa)
	nmi	Uncharacterized protein. (466 aa)
	gbp5	Signal sequence receptor, delta. (636 aa)
	gbp3	Homeobox A9. (555 aa)
	gbp1	GB1/RHD3-type G domain-containing protein. (603 aa)
	LOC100490060	CD274 molecule. (498 aa)
	acod1lb	Centromere protein K. (498 aa)
	slc26a6	STAS domain-containing protein. (737 aa)
	vamp3	V-SNARE coiled-coil homology domain-containing protein. (118 aa)
	ADAMTS13	ADAM metallopeptidase with thrombospondin type 1 motif 13. (1350 aa)
	rab20	Intraflagellar transport protein 122 homolog. (272 aa)
	ENSXETP00000022548	IL12p40_C domain-containing protein. (249 aa)
	stxbp3	Syntaxin binding protein 3; Belongs to the STXBP/unc-18/SEC1 family. (589 aa)
	Ccl20	C-C motif chemokine. (85 aa)
	ACOD1	Aconitate decarboxylase 1. (474 aa)
	rab7b	Uncharacterized protein. (201 aa)
	stxbp4	Uncharacterized protein. (516 aa)
	hpx	MORC family CW-type zinc finger 2. (320 aa)
	LOC100487834	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (319 aa)
	myo1c	Nucleolar protein 4; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1075 aa)
	tp53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (362 aa)
	cldn1	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
	cdc42ep2	Cdc42 effector protein 2; Probably involved in the organization of the actin cytoskeleton; Belongs to the BORG/CEP family. (213 aa)
	stx8	t-SNARE coiled-coil homology domain-containing protein. (272 aa)
	eprs1	Solute carrier family 12, member 9. (1715 aa)
	PDE12	Phosphodiesterase 12. (537 aa)
	mrc1	Origin recognition complex subunit 3. (1428 aa)
	aqp4	Peptidylprolyl isomerase like 2; Belongs to the MIP/aquaporin (TC 1.A.8) family. (318 aa)
	ENSXETP00000053506	NACHT domain-containing protein. (837 aa)
	LOC101733960	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (285 aa)

Your Current Organism:

Xenopus tropicalis

NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACOD1	acod1lb	ENSXETP00000027846	ENSXETP00000014878	Aconitate decarboxylase 1.	Centromere protein K.	0.902
acod1lb	ACOD1	ENSXETP00000014878	ENSXETP00000027846	Centromere protein K.	Aconitate decarboxylase 1.	0.902
stx8	vamp3	ENSXETP00000047772	ENSXETP00000016005	t-SNARE coiled-coil homology domain-containing protein.	V-SNARE coiled-coil homology domain-containing protein.	0.638
stxbp3	vamp3	ENSXETP00000023410	ENSXETP00000016005	Syntaxin binding protein 3; Belongs to the STXBP/unc-18/SEC1 family.	V-SNARE coiled-coil homology domain-containing protein.	0.595
vamp3	stx8	ENSXETP00000016005	ENSXETP00000047772	V-SNARE coiled-coil homology domain-containing protein.	t-SNARE coiled-coil homology domain-containing protein.	0.638
vamp3	stxbp3	ENSXETP00000016005	ENSXETP00000023410	V-SNARE coiled-coil homology domain-containing protein.	Syntaxin binding protein 3; Belongs to the STXBP/unc-18/SEC1 family.	0.595

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