(17 nodes) DNA demethylation network (Xenopus tropicalis)

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second shell of interactors

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Your Input:
	TET2	Tet methylcytosine dioxygenase 2. (1797 aa)
	ALKBH3	AlkB homolog 3, alpha-ketoglutaratedependent dioxygenase. (581 aa)
	alkbh4	CDGSH iron-sulfur domain-containing protein 2. (308 aa)
	washc5	WASH complex subunit 5; Acts at least in part as component of the WASH complex which seems to regulate washc1 nucleation-promoting factor (NPF) activity and is required for its membrane targeting during endosomal sorting. (1159 aa)
	ENSXETP00000047005	Uncharacterized protein. (222 aa)
	alkbh1	Solute carrier family 35 member D3. (398 aa)
	alkbh2	Glucose-6-phosphatase, catalytic, 2. (345 aa)
	LOC100485335	Poly(A) polymerase alpha. (281 aa)
	apobec2	Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2. (234 aa)
	apex1	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (363 aa)
	tdg	UDG domain-containing protein. (459 aa)
	eomes	Autophagy related 12. (674 aa)
	tet3	Methylcytosine dioxygenase tet3; Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development. Conversion of 5mC into 5hmC probably constitutes the first step in cytosine demethylation. Selectively binds to the promoter region of target genes and contributes to regulate the expression of numerous developmental genes, including pax6, rax, sox9 and six3. May also contribute to the regulation of target genes in ways that do not requir [...] (1925 aa)
	fto	FTO_NTD domain-containing protein. (513 aa)
	nap1l1	Nucleosome assembly protein 1-like 1; Acts as a chaperone for the linker histone to facilitate deposition of histone B4 onto linker DNA. Required for both remodeling of sperm chromatin into nucleosomes, and linker histone binding to nucleosome core dimers. Plays a role in tissue-specific gene regulation. Required for primitive hemopoiesis, acting upstream of tal1/scl (By similarity); Belongs to the nucleosome assembly protein (NAP) family. (402 aa)
	pax6	Uncharacterized protein. (456 aa)
	stac	SH3 and cysteine rich domain. (220 aa)

Your Current Organism:

Xenopus tropicalis

NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALKBH3	alkbh1	ENSXETP00000000796	ENSXETP00000040146	AlkB homolog 3, alpha-ketoglutaratedependent dioxygenase.	Solute carrier family 35 member D3.	0.514
ENSXETP00000047005	tdg	ENSXETP00000047005	ENSXETP00000020564	Uncharacterized protein.	UDG domain-containing protein.	0.466
alkbh1	ALKBH3	ENSXETP00000040146	ENSXETP00000000796	Solute carrier family 35 member D3.	AlkB homolog 3, alpha-ketoglutaratedependent dioxygenase.	0.514
alkbh1	alkbh2	ENSXETP00000040146	ENSXETP00000038071	Solute carrier family 35 member D3.	Glucose-6-phosphatase, catalytic, 2.	0.715
alkbh1	alkbh4	ENSXETP00000040146	ENSXETP00000054422	Solute carrier family 35 member D3.	CDGSH iron-sulfur domain-containing protein 2.	0.659
alkbh1	fto	ENSXETP00000040146	ENSXETP00000007393	Solute carrier family 35 member D3.	FTO_NTD domain-containing protein.	0.633
alkbh2	alkbh1	ENSXETP00000038071	ENSXETP00000040146	Glucose-6-phosphatase, catalytic, 2.	Solute carrier family 35 member D3.	0.715
alkbh2	alkbh4	ENSXETP00000038071	ENSXETP00000054422	Glucose-6-phosphatase, catalytic, 2.	CDGSH iron-sulfur domain-containing protein 2.	0.543
alkbh2	fto	ENSXETP00000038071	ENSXETP00000007393	Glucose-6-phosphatase, catalytic, 2.	FTO_NTD domain-containing protein.	0.461
alkbh4	alkbh1	ENSXETP00000054422	ENSXETP00000040146	CDGSH iron-sulfur domain-containing protein 2.	Solute carrier family 35 member D3.	0.659
alkbh4	alkbh2	ENSXETP00000054422	ENSXETP00000038071	CDGSH iron-sulfur domain-containing protein 2.	Glucose-6-phosphatase, catalytic, 2.	0.543
apex1	tdg	ENSXETP00000024300	ENSXETP00000020564	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	UDG domain-containing protein.	0.563
apobec2	tdg	ENSXETP00000028690	ENSXETP00000020564	Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2.	UDG domain-containing protein.	0.510
fto	alkbh1	ENSXETP00000007393	ENSXETP00000040146	FTO_NTD domain-containing protein.	Solute carrier family 35 member D3.	0.633
fto	alkbh2	ENSXETP00000007393	ENSXETP00000038071	FTO_NTD domain-containing protein.	Glucose-6-phosphatase, catalytic, 2.	0.461
stac	tdg	ENSXETP00000003299	ENSXETP00000020564	SH3 and cysteine rich domain.	UDG domain-containing protein.	0.573
tdg	ENSXETP00000047005	ENSXETP00000020564	ENSXETP00000047005	UDG domain-containing protein.	Uncharacterized protein.	0.466
tdg	apex1	ENSXETP00000020564	ENSXETP00000024300	UDG domain-containing protein.	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	0.563
tdg	apobec2	ENSXETP00000020564	ENSXETP00000028690	UDG domain-containing protein.	Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2.	0.510
tdg	stac	ENSXETP00000020564	ENSXETP00000003299	UDG domain-containing protein.	SH3 and cysteine rich domain.	0.573

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