STRINGSTRING
nr1d1 nr1d1 tnf tnf sri sri LOC101730668 LOC101730668 blk blk sox1 sox1 sirt4 sirt4 crhbp crhbp SYT9 SYT9 ffar3 ffar3 FFAR2 FFAR2 hadh hadh pdx1 pdx1 LOC101733206 LOC101733206 ENSXETP00000012046 ENSXETP00000012046 tm7sf3 tm7sf3 lrrc8a lrrc8a TNFSF11 TNFSF11 slc8b1 slc8b1 pdhx-2 pdhx-2 psmd9 psmd9 c2cd2l c2cd2l sirt6 sirt6 fam3d fam3d lrp5 lrp5 fgb fgb FGG FGG midn midn ACSL4 ACSL4 rph3al rph3al aimp1 aimp1 Il6 Il6 DRD2 DRD2 arntl arntl RFX6 RFX6 klf7 klf7 stxbp4 stxbp4 CAPN10 CAPN10 ccn3 ccn3 foxo1 foxo1 aacs aacs mpc2 mpc2 tmtc3-2 tmtc3-2 hmgn3 hmgn3 PIM3 PIM3 ENSXETP00000032157 ENSXETP00000032157 adprm-2 adprm-2 myrip myrip lep lep acvr1c acvr1c INHBB INHBB syt7 syt7 bad bad pick1-2 pick1-2 adcyap1 adcyap1 efna5 efna5 PLA2G6 PLA2G6 SYTL4 SYTL4 gper1 gper1 selenot selenot REST REST phkg2-2 phkg2-2 HTR2C HTR2C PASK PASK scpep1-2 scpep1-2 trh trh NDUFAF2 NDUFAF2 wnk3 wnk3 nr1h4 nr1h4 cftr cftr il1b il1b LOC100485454 LOC100485454 crh crh rfx3 rfx3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
nr1d1Heparan sulfate 6-O-sulfotransferase 3. (529 aa)
tnfThyrotropin-releasing hormone receptor 3. (227 aa)
sriSorcin. (195 aa)
LOC101730668ABC transporter domain-containing protein. (310 aa)
blkTyrosine-protein kinase. (497 aa)
sox13-phosphoinositide dependent protein kinase 1. (663 aa)
sirt4NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily. (322 aa)
crhbpCorticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (321 aa)
SYT9Synaptotagmin 9. (509 aa)
ffar3Amylase, alpha 2B (pancreatic); Belongs to the G-protein coupled receptor 1 family. (322 aa)
FFAR2Free fatty acid receptor 2; Belongs to the G-protein coupled receptor 1 family. (331 aa)
hadhVPS41, HOPS complex subunit. (315 aa)
pdx1Hepatocyte nuclear factor 4, beta. (271 aa)
LOC101733206Pro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. (226 aa)
ENSXETP00000012046G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (317 aa)
tm7sf3Histone-binding protein RBBP4. (505 aa)
lrrc8aCWC27 spliceosome-associated protein. (809 aa)
TNFSF11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (290 aa)
slc8b1Uncharacterized protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (584 aa)
pdhx-2Oxysterol binding protein like 10. (49 aa)
psmd9Ryanodine receptor 1 (skeletal). (211 aa)
c2cd2lUncharacterized protein. (662 aa)
sirt6Sirtuin (Silent mating type information regulation 2 homolog) 6. (331 aa)
fam3dFamily with sequence similarity 3, member D. (226 aa)
lrp5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1634 aa)
fgbFibrinogen C-terminal domain-containing protein. (496 aa)
FGGFibrinogen gamma chain. (438 aa)
midnMidnolin; Facilitates ubiquitin-independent proteasomal degradation of polycomb protein CBX4. Plays a role in inhibiting the activity of glucokinase GCK and both glucose-induced and basal insulin secretion. (453 aa)
ACSL4Acyl-CoA synthetase long chain family member 4. (633 aa)
rph3alUncharacterized protein. (351 aa)
aimp1tRNA-binding domain-containing protein. (313 aa)
Il6Uncharacterized protein. (150 aa)
DRD2G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (440 aa)
arntlSin3A associated protein 18kDa. (513 aa)
RFX6Regulatory factor X6. (931 aa)
klf7Kruppel-like factor 7 (Ubiquitous). (296 aa)
stxbp4Uncharacterized protein. (516 aa)
CAPN10Calpain 10; Belongs to the peptidase C2 family. (666 aa)
ccn3Superoxide dismutase [Cu-Zn]. (344 aa)
foxo1Forkhead box protein O1; Transcription factor. (626 aa)
aacsAcetoacetyl-CoA synthetase; Activates acetoacetate to acetoacetyl-CoA. (727 aa)
mpc2Mitochondrial pyruvate carrier; Mediates the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. (132 aa)
tmtc3-2Transmembrane and tetratricopeptide repeat containing 3. (152 aa)
hmgn3Integrin subunit alpha 2b. (124 aa)
PIM3Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (323 aa)
ENSXETP00000032157Ion_trans domain-containing protein. (263 aa)
adprm-2Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase. (317 aa)
myripSelenoprotein N. (833 aa)
lepLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. (169 aa)
acvr1cReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (537 aa)
INHBBInhibin subunit beta B. (131 aa)
syt7C2 domain-containing protein. (777 aa)
badSMC5-SMC6 complex localization factor 1. (151 aa)
pick1-2Uncharacterized protein. (421 aa)
adcyap1Cramped chromatin regulator homolog 1. (187 aa)
efna5Ephrin-A5; Belongs to the ephrin family. (228 aa)
PLA2G6Phospholipase A2 group VI. (806 aa)
SYTL4Synaptotagmin like 4. (692 aa)
gper1Tripartite motif containing 55; Belongs to the G-protein coupled receptor 1 family. (361 aa)
selenotThioredoxin reductase-like selenoprotein T; Selenoprotein with thioredoxin reductase-like oxidoreductase activity; Belongs to the SelWTH family. Selenoprotein T subfamily. (201 aa)
RESTRE1 silencing transcription factor. (1442 aa)
phkg2-2Lines homolog 1. (358 aa)
HTR2C5-hydroxytryptamine receptor 2C. (475 aa)
PASKPAS domain containing serine/threonine kinase. (1189 aa)
scpep1-2Serine carboxypeptidase 1. (48 aa)
trhPro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. (226 aa)
NDUFAF2NADH:ubiquinone oxidoreductase complex assembly factor 2. (161 aa)
wnk3Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1213 aa)
nr1h4Protein phosphatase 5, catalytic subunit. (458 aa)
cftrCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1493 aa)
il1bInterleukin-1; Belongs to the IL-1 family. (286 aa)
LOC100485454CRF domain-containing protein. (226 aa)
crhCRF domain-containing protein. (207 aa)
rfx3Transcription factor RFX3; Transcription factor required for ciliogenesis and islet cell differentiation during endocrine pancreas development; Belongs to the RFX family. (783 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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