STRINGSTRING
fbn1 fbn1 smurf2 smurf2 IL17RD IL17RD emilin1 emilin1 stk11 stk11 WNT1 WNT1 bmp2 bmp2 chrdl1 chrdl1 fgf1 fgf1 lats2 lats2 ep300 ep300 erp29-2 erp29-2 msx1 msx1 pik3cb pik3cb strap strap kiaa1324l kiaa1324l GLG1 GLG1 vasn vasn znf451 znf451 arg1-2 arg1-2 smad2 smad2 SMAD6 SMAD6 smad3 smad3 kdr kdr SMAD7 SMAD7 cyfip2 cyfip2 ENSXETP00000007837 ENSXETP00000007837 ccn1 ccn1 sfrp5 sfrp5 fkbp8 fkbp8 zcchc4 zcchc4 spry2 spry2 fstl3 fstl3 szl szl ilk ilk pelo pelo spry1 spry1 SKI SKI DAB2 DAB2 wfikkn1 wfikkn1 chrd.1 chrd.1 pin1 pin1 VEGFC VEGFC CADM4 CADM4 TNFAIP6 TNFAIP6 bmper bmper HJV HJV nrp1 nrp1 ing2 ing2 cdkn2b cdkn2b sf1 sf1 cd63 cd63 gipc1 gipc1 cask cask vim-2 vim-2 LOC733765 LOC733765 bmp4 bmp4 irx1 irx1 smurf1 smurf1 LOC100492768 LOC100492768 VWC2 VWC2 nbl1 nbl1 SNX25 SNX25 nrros nrros ppara ppara spred3 spred3 ldlrad4 ldlrad4 MMRN2 MMRN2 sfrp2 sfrp2 PRDM14 PRDM14 chst11 chst11 LOC100494742 LOC100494742 BCL9L BCL9L pmepa1 pmepa1 ENSXETP00000020321 ENSXETP00000020321 ENSXETP00000020341 ENSXETP00000020341 ENSXETP00000020392 ENSXETP00000020392 sulf1 sulf1 RBPMS2 RBPMS2 tgfb1 tgfb1 tmem204 tmem204 apln apln numa1 numa1 spart spart FZD4 FZD4 ENSXETP00000022548 ENSXETP00000022548 hgs hgs ube2o ube2o ptp4a3 ptp4a3 LOC100486858 LOC100486858 dlc dlc CCBE1 CCBE1 RNF165 RNF165 SPRY4 SPRY4 ccn1l ccn1l Smad6.2 Smad6.2 ovos2-3 ovos2-3 shisa2 shisa2 LOC101734414 LOC101734414 fgfbp1 fgfbp1 CYFIP1 CYFIP1 flcn flcn eng eng nog nog nradd nradd rnf111 rnf111 gpc1 gpc1 dll1 dll1 SKOR1 SKOR1 dkk1 dkk1 cnppd1-2 cnppd1-2 dstyk dstyk CREB3L1 CREB3L1 smad4.1 smad4.1 cyb5r3-2 cyb5r3-2 crb2 crb2 foxc1 foxc1 hspa5 hspa5 twsg1 twsg1 sp9 sp9 cited2 cited2 mpp5 mpp5 VEPH1 VEPH1 cdh5 cdh5 lrit3 lrit3 fgf4 fgf4 acvrl1 acvrl1 THBS1 THBS1 slit2 slit2 lemd3 lemd3 sorl1 sorl1 ctdspl2 ctdspl2 lingo3 lingo3 wasf1 wasf1 cidea cidea fst fst LOC100488346 LOC100488346 agt agt ptpn1 ptpn1 nog2 nog2 adam17 adam17 htra3 htra3 fbxl15 fbxl15 ZNF423 ZNF423 LOC100496423 LOC100496423 cav3.2 cav3.2 PRDM16 PRDM16 snw1 snw1 skil skil myo1c myo1c frzb2 frzb2 znf703 znf703 zeb1 zeb1 tp53 tp53 spry3 spry3 sulf2 sulf2 jcad jcad bambi bambi FAM20C FAM20C ppm1a ppm1a CRIM1 CRIM1 ctnnb1 ctnnb1 LOC100497845 LOC100497845 cer1 cer1 hhip hhip gata3 gata3 WFIKKN2 WFIKKN2 gipc2 gipc2 VWC2L VWC2L cav3.1 cav3.1 sostdc1 sostdc1 dcn dcn myocd myocd fgfbp3 fgfbp3 agtr2 agtr2 ITGA3 ITGA3 cav2 cav2 cav1 cav1 sirt1 sirt1 sfrp1 sfrp1 TSPAN12 TSPAN12 LATS1 LATS1 TGFBR3 TGFBR3 BMPR2 BMPR2 grem1 grem1 gipc3 gipc3 Lrg1 Lrg1 nptn nptn
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
fbn1Abl interactor 1. (2882 aa)
smurf2Bcl2 modifying factor. (577 aa)
IL17RDInterleukin 17 receptor D. (729 aa)
emilin1Uncharacterized protein. (1057 aa)
stk11Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (442 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)
bmp2Armadillo like helical domain containing 3. (398 aa)
chrdl1Uncharacterized protein. (346 aa)
fgf1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
lats2Uncharacterized protein. (1158 aa)
ep300Suv3 like RNA helicase. (2493 aa)
erp29-2Endoplasmic reticulum protein 29. (164 aa)
msx1Potassium channel, two pore domain subfamily K, member 18. (275 aa)
pik3cbSolute carrier family 27 member 6; Belongs to the PI3/PI4-kinase family. (1085 aa)
strapWD_REPEATS_REGION domain-containing protein. (260 aa)
kiaa1324lBMS1, ribosome biogenesis factor. (995 aa)
GLG1Golgi glycoprotein 1. (1148 aa)
vasnVasorin; May act as an inhibitor of TGF-beta signaling. (673 aa)
znf451Uncharacterized protein. (1034 aa)
arg1-2Arginase 1. (280 aa)
smad2Mothers against decapentaplegic homolog. (467 aa)
SMAD6Mothers against decapentaplegic homolog. (352 aa)
smad3Mothers against decapentaplegic homolog. (461 aa)
kdrTransglutaminase 6; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1349 aa)
SMAD7Mothers against decapentaplegic homolog. (382 aa)
cyfip2Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1266 aa)
ENSXETP00000007837Uncharacterized protein. (195 aa)
ccn1Histone deacetylase 2. (376 aa)
sfrp5Secreted frizzled-related protein 5. (315 aa)
fkbp8Peptidylprolyl isomerase. (408 aa)
zcchc4rRNA N6-adenosine-methyltransferase ZCCHC4; rRNA N6-methyltransferase that specifically methylates the adenine in position 4220 of 28S rRNA. N6-methylation of adenine(4220) in 28S rRNA is required for translation. (487 aa)
spry2Sprouty homolog 2. (314 aa)
fstl3Follistatin-like 3 (Secreted glycoprotein). (255 aa)
szlN-acetylgalactosaminidase, alpha-. (281 aa)
ilkUncharacterized protein. (286 aa)
peloUncharacterized protein. (290 aa)
spry1Mitochondrial amidoxime reducing component 1. (342 aa)
SKISKI proto-oncogene. (719 aa)
DAB2DAB adaptor protein 2. (820 aa)
wfikkn1Carbohydrate (keratan sulfate Gal-6) sulfotransferase 1. (545 aa)
chrd.1Chordin; Belongs to the chordin family. (942 aa)
pin1Peptidyl-prolyl cis-trans isomerase. (159 aa)
VEGFCVascular endothelial growth factor C. (407 aa)
CADM4Cell adhesion molecule 4. (394 aa)
TNFAIP6TNF alpha induced protein 6. (269 aa)
bmperUncharacterized protein. (741 aa)
HJVHemojuvelin BMP co-receptor. (402 aa)
nrp1Neuropilin; Belongs to the neuropilin family. (926 aa)
ing2Inhibitor of growth protein. (279 aa)
cdkn2bCyclin-dependent kinase inhibitor 2B (P15, inhibits CDK4). (125 aa)
sf1Uncharacterized protein. (674 aa)
cd63Tetraspanin. (246 aa)
gipc1GIPC PDZ domain containing family, member 1. (332 aa)
caskWW domain binding protein 11; Belongs to the MAGUK family. (926 aa)
vim-2GTPase, very large interferon-inducible pseudogene 1. (387 aa)
LOC733765Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (141 aa)
bmp4Zinc finger, HIT-type-containing 6. (469 aa)
irx1Iroquois-class homeodomain protein irx-1; Acts partially redundantly with other irx members in neural patterning. Required for formation of the posterior forebrain, midbrain, hindbrain, and to a lesser extent, spinal cord. Acts early in neural plate development to induce expression of some but not all proneural genes, and specify a neural precursor state. Also up- regulates repressors that prevent neuronal differentiation. Patterns the neuroectoderm in both the anterior/posterior and dorsal/ventral axes. Acts primarily as a transcriptional repressor during neural development, and binds [...] (467 aa)
smurf1E3 ubiquitin-protein ligase. (748 aa)
LOC100492768Peptidylprolyl isomerase. (424 aa)
VWC2Von Willebrand factor C domain containing 2. (325 aa)
nbl1Neuroblastoma suppressor of tumorigenicity 1; May act as a tumor suppressor. Cytokine that has an axial patterning activity. Acts like bone morpho-genetic protein (BMP) antagonist in embryonic explants. Blocks the bmp2 activity (By similarity). (211 aa)
SNX25Sorting nexin 25. (1046 aa)
nrrosCytoskeleton associated protein 5. (679 aa)
pparaLysosomal-associated membrane protein 1. (474 aa)
spred3Glycerol-3-phosphate acyltransferase 3. (424 aa)
ldlrad4Hepatocyte nuclear factor 4 alpha. (310 aa)
MMRN2Multimerin 2. (765 aa)
sfrp2Secreted frizzled-related protein 2. (295 aa)
PRDM14PR/SET domain 14. (531 aa)
chst11Carbohydrate sulfotransferase. (352 aa)
LOC100494742DNA polymerase mu. (518 aa)
BCL9LBCL9 like. (1282 aa)
pmepa1Uncharacterized protein. (285 aa)
ENSXETP00000020321S-adenosylmethionine sensor upstream of mTORC1. (158 aa)
ENSXETP00000020341Uncharacterized protein. (159 aa)
ENSXETP00000020392Uncharacterized protein. (157 aa)
sulf1Uncharacterized protein. (1145 aa)
RBPMS2RNA binding protein, mRNA processing factor 2. (198 aa)
tgfb1Transforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
tmem204Prickle planar cell polarity protein 2. (223 aa)
aplnLOC100135238 protein. (76 aa)
numa1Kynurenine aminotransferase 3. (2351 aa)
spartMIT domain-containing protein. (592 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (523 aa)
ENSXETP00000022548IL12p40_C domain-containing protein. (249 aa)
hgsImmunoglobulin heavy chain precursor. (792 aa)
ube2oPhytanoyl-CoA hydroxylase-interacting protein-like. (1406 aa)
ptp4a3Prefoldin subunit 4. (173 aa)
LOC100486858Chloride channel CLIC-like 1. (353 aa)
dlcDelta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (642 aa)
CCBE1Collagen and calcium binding EGF domains 1. (394 aa)
RNF165Ring finger protein 165. (235 aa)
SPRY4Sprouty RTK signaling antagonist 4. (297 aa)
ccn1lUncharacterized protein. (238 aa)
Smad6.2MH2 domain-containing protein. (206 aa)
ovos2-3Alpha-2-macroglobulin like 1 pseudogene. (2368 aa)
shisa2RCC1 like. (209 aa)
LOC101734414One cut homeobox 1, gene 2. (229 aa)
fgfbp1Protein phosphatase, Mg2+/Mn2+ dependent 1L. (224 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1272 aa)
flcnFolliculin; Belongs to the folliculin family. (579 aa)
engUncharacterized protein. (622 aa)
nogNoggin; Belongs to the noggin family. (222 aa)
nraddHigh mobility group box 3. (390 aa)
rnf111E3 ubiquitin-protein ligase arkadia; E3 ubiquitin-protein ligase required for mesoderm patterning during embryonic development (By similarity). Acts as an enhancer of the transcriptional responses of the smad2/smad3 effectors, which are activated downstream of BMP. Acts by mediating ubiquitination and degradation of SMAD inhibitors such as smad7, inducing their proteasomal degradation and thereby enhancing the transcriptional activity of TGF-beta and BMP. Specifically binds polysumoylated chains via SUMO interaction motifs (SIMs) and mediates ubiquitination of sumoylated substrates (By [...] (981 aa)
gpc1Secreted glypican-1; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (565 aa)
dll1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (740 aa)
SKOR1SKI family transcriptional corepressor 1. (742 aa)
dkk1Dickkopf 1. (257 aa)
cnppd1-2Caspase 2. (84 aa)
dstykDual serine/threonine and tyrosine protein kinase; May act as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. May induce both caspase-dependent apoptosis and caspase-independent cell death. May play a role in the embryonic development. (963 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (467 aa)
smad4.1Mothers against decapentaplegic homolog. (579 aa)
cyb5r3-2Cytochrome b5 reductase 3. (278 aa)
crb2EMI domain containing 1. (1456 aa)
foxc1Forkhead box protein C1; DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as eye, bones, cardiovascular, kidney and skin development. Acts either as a transcriptional activator or repressor. Binds to the consensus binding site 5'-[G/C][A/T]AAA[T/C]AA[A/C]-3' in promoter of target genes. Upon DNA-binding, promotes DNA bending. Required for cell viability and resistance to oxidative stress in the eye. Promotes cell growth inhibition by stopping the cell cycle in the G1 phase through TGFB1- mediated signals. Involved in epi [...] (495 aa)
hspa5Neuronal vesicle trafficking associated 1; Belongs to the heat shock protein 70 family. (656 aa)
twsg1Uncharacterized protein. (339 aa)
sp9Transcription factor Sp9; Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos (By similarity). (422 aa)
cited2Cbp/p300-interacting transactivator 2; Transcriptional coactivator or corepressor of the p300/CBP- mediated transcription complex. May be involved in sex determination, early gonad development, left-right patterning during embryogenesis and differentiation of the adrenal cortex (By similarity); Belongs to the CITED family. (281 aa)
mpp5Uncharacterized protein; Belongs to the MAGUK family. (702 aa)
VEPH1Ventricular zone expressed PH domain containing 1. (827 aa)
cdh5Zinc finger RNA-binding protein; Cadherins are calcium-dependent cell adhesion proteins. (772 aa)
lrit3Guanylate cyclase activator 1A like. (654 aa)
fgf4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (192 aa)
acvrl1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (490 aa)
THBS1Thrombospondin 1. (1188 aa)
slit2ATPase family, AAA domain containing 3A. (1564 aa)
lemd3LEM domain-containing protein. (782 aa)
sorl1Tubulin tyrosine ligase like 4. (2146 aa)
ctdspl2CTD small phosphatase-like protein 2; Probable phosphatase. (466 aa)
lingo3Ig-like domain-containing protein. (605 aa)
wasf1Wasf1 protein. (558 aa)
cideaCell death-inducing DFFA-like effector a. (221 aa)
fstChloride channel, voltage-sensitive 6. (343 aa)
LOC100488346Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1239 aa)
agtSERPIN domain-containing protein; Belongs to the serpin family. (459 aa)
ptpn1Tyrosine-protein phosphatase non-receptor type. (449 aa)
nog2Noggin; Belongs to the noggin family. (218 aa)
adam17Monooxygenase, DBH-like 2, pseudogene. (834 aa)
htra3Proteasome subunit alpha 1. (464 aa)
fbxl15F-box/LRR-repeat protein 15; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Acts as a positive regulator of the BMP signaling pathway). Required for dorsal/ventral pattern formation (By similarity; Belongs to the FBXL15 family. (298 aa)
ZNF423Zinc finger protein 423. (1289 aa)
LOC100496423Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (164 aa)
cav3.2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (153 aa)
PRDM16PR/SET domain 16. (1168 aa)
snw1Kelch repeat and BTB domain-containing protein 8. (549 aa)
skilc-SKI_SMAD_bind domain-containing protein. (643 aa)
myo1cNucleolar protein 4; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1075 aa)
frzb2Frzb2 protein. (300 aa)
znf703Zinc finger protein 703; Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters. Regulates cell adhesion, migration and proliferation. May be required for segmental gene expression during hindbrain development (By similarity); Belongs to the Elbow/Noc family. (537 aa)
zeb1Ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1. (1121 aa)
tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (362 aa)
spry3DnaJ homolog subfamily C member 25. (289 aa)
sulf2Extracellular sulfatase. (875 aa)
jcadLegumain. (1096 aa)
bambiBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
FAM20CFAM20C golgi associated secretory pathway kinase. (575 aa)
ppm1aPpm1a protein. (383 aa)
CRIM1Cysteine rich transmembrane BMP regulator 1. (1037 aa)
ctnnb1Dynactin subunit 5. (788 aa)
LOC100497845Mannosidase, beta A, lysosomal. (803 aa)
cer1Cerberus short; Inhibits wnt, nodal/nr-1 and bmp signaling in the embryo to promote head formation and anterior neural induction. Within the endoderm, acts as an essential mediator of nodal/nr-1-induced cardiogenesis in the overlying mesoderm (By similarity). (187 aa)
hhipSecurin-like. (678 aa)
gata3Uncharacterized protein. (454 aa)
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2. (559 aa)
gipc2Solute carrier family 4, sodium bicarbonate cotransporter, member 7. (333 aa)
VWC2LVon Willebrand factor C domain containing 2 like. (222 aa)
cav3.1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (155 aa)
sostdc1Transmembrane protein 52. (213 aa)
dcnDecorin; May affect the rate of fibrils formation. (364 aa)
myocdYip1 domain family member 1. (956 aa)
fgfbp3Fibroblast growth factor binding protein 3. (261 aa)
agtr2Crystallin beta-gamma domain-containing 1; Belongs to the G-protein coupled receptor 1 family. (352 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1046 aa)
cav2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (160 aa)
cav1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (180 aa)
sirt1Thrombospondin-type laminin G domain and EAR repeats. (707 aa)
sfrp1Uncharacterized protein. (304 aa)
TSPAN12Tetraspanin. (304 aa)
LATS1Large tumor suppressor kinase 1. (1117 aa)
TGFBR3Transforming growth factor beta receptor 3. (864 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1053 aa)
grem1Gremlin. (182 aa)
gipc3PDZ domain-containing protein. (338 aa)
Lrg1LRRCT domain-containing protein. (336 aa)
nptnUncharacterized protein. (407 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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