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| | ENSXETP00000016609 | Reverse transcriptase domain-containing protein. (791 aa) |
| | pold1 | DNA polymerase. (1191 aa) |
| | cpsf4 | Cleavage and polyadenylation specificity factor subunit 4; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Cpsf4 binds RNA polymers with a preference for poly(U) (By similarity). (297 aa) |
| | DNA2 | DNA replication ATP-dependent helicase/nuclease DNA2; Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazaki fragments processing by cleaving long flaps that escape fen1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit dna2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA, while the 3'-ssDNA cleavage is prevented by [...] (1100 aa) |
| | dxo | RAI1 domain-containing protein. (488 aa) |
| | dcp2 | Nudix hydrolase domain-containing protein. (487 aa) |
| | nthl1 | Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family. (300 aa) |
| | thbs4-2 | Thrombospondin 4. (397 aa) |
| | LOC100135188 | Junction-mediating and -regulatory protein. (371 aa) |
| | isg20l2 | Ankyrin repeat domain 45. (432 aa) |
| | ENSXETP00000014366 | Uncharacterized protein. (100 aa) |
| | piwil3 | Uncharacterized protein; Belongs to the argonaute family. (869 aa) |
| | cpsf3 | Uncharacterized protein. (692 aa) |
| | rpp21 | Ribonuclease P 21kDa subunit. (154 aa) |
| | xrn2 | 5'-3' exoribonuclease; Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II. (960 aa) |
| | n4bp2l1 | Tau tubulin kinase 2. (224 aa) |
| | letm1 | Mitochondrial proton/calcium exchanger protein; Mitochondrial proton/calcium antiporter that mediates proton- dependent calcium efflux from mitochondrion (By similarity). Required for the maintenance of the tubular shape and cristae organization (By similarity). (766 aa) |
| | cpsf7 | NK6 homeobox 1. (462 aa) |
| | b4galnt4 | Beta-1,4-N-acetylgalactosaminyltransferase; Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'- diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans. (1138 aa) |
| | fen1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (382 aa) |
| | ccdc124-2 | Coiled-coil domain-containing protein 124. (816 aa) |
| | rpp40 | Shootin 1. (359 aa) |
| | utp23 | Uncharacterized protein. (246 aa) |
| | rnaseh2a | Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (303 aa) |
| | pelo | Uncharacterized protein. (290 aa) |
| | dffb | GPALPP motifs containing 1. (380 aa) |
| | sulf1-2 | Sulfatase 1. (844 aa) |
| | exosc10 | Sigma non-opioid intracellular receptor 1. (891 aa) |
| | mrps15-3 | Uncharacterized protein. (1169 aa) |
| | endoul | Poly(U)-specific endoribonuclease; Poly(U)-specific endoribonuclease involved in the biosynthesis of intron-encoded box C/D snoRNAs, such as U16 and U86. Releases products that have 2'-3'-cyclic phosphate termini (By similarity); Belongs to the ENDOU family. (317 aa) |
| | exosc2 | Uncharacterized protein. (293 aa) |
| | exosc9 | ER lumen protein-retaining receptor 3. (432 aa) |
| | zgrf1 | Uncharacterized protein. (1945 aa) |
| | LOC101732272 | Ribophorin I. (284 aa) |
| | nmbr-2 | Neuromedin B receptor. (327 aa) |
| | elac1 | Elac1 (Prov). (363 aa) |
| | parn | QKI, KH domain containing, RNA binding. (632 aa) |
| | usb1 | U6 snRNA phosphodiesterase; Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA; Belongs to the 2H phosphoesterase superfamily. USB1 family. (251 aa) |
| | ddx1 | ATP-dependent RNA helicase DDX1; Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5' single-stranded RNA overhang nuclease activity. Acts as a positive regulator of transcription. May be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. Binds DNA and RNA. Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit rtcb. Binds (via helicase ATP-binding domain) on both short and long poly(I:C) dsRNA (By similarity); Belongs to the DEAD box helicase family. DDX1 subfamily. (737 aa) |
| | xrn1 | Ribosomal protein L29. (1740 aa) |
| | slx1a | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (277 aa) |
| | pld3 | 5'-3' exonuclease PLD3; 5'->3' DNA exonuclease which digests single-stranded DNA (ssDNA) (By similarity). Regulates inflammatory cytokine responses via the degradation of nucleic acids, by reducing the concentration of ssDNA able to stimulate TLR9, a nucleotide-sensing receptor in collaboration with PLD4 (By similarity). May be important in myotube formation. Plays a role in lysosomal homeostasis. Involved in the regulation of endosomal protein sorting (By similarity). (503 aa) |
| | piwil4 | Branched chain keto acid dehydrogenase E1, beta polypeptide; Belongs to the argonaute family. (822 aa) |
| | trir | LOC100145043 protein. (243 aa) |
| | apex2 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (563 aa) |
| | angel2 | La ribonucleoprotein domain family member 4. (526 aa) |
| | TATDN3 | TatD DNase domain containing 3. (273 aa) |
| | aplf | Uncharacterized protein. (509 aa) |
| | aste1 | XPG_I_2 domain-containing protein. (663 aa) |
| | psmb1-2 | Proteasome subunit beta 1; Belongs to the pancreatic ribonuclease family. (165 aa) |
| | dis3l | DIS3-like exonuclease 1; Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. (1061 aa) |
| | pld6 | Mitochondrial cardiolipin hydrolase; Regulates mitochondrial shape through facilitating mitochondrial fusion. During spermatogenesis, plays a critical role in PIWI-interacting RNA (piRNA) biogenesis (By similarity). piRNAs provide essential protection against the activity of mobile genetic elements. piRNA-mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation. Has been shown to be a backbone-non-specific, single strand-specific nuclease, cleavin [...] (210 aa) |
| | nop9 | LOC100158615 protein. (623 aa) |
| | LOC100487906 | DDE Tnp4 domain-containing protein. (350 aa) |
| | spred3-3 | Dedicator of cytokinesis 4. (221 aa) |
| | kank2-2 | Deoxyribonuclease; Belongs to the DNase I family. (293 aa) |
| | endov | Cytosolic purine 5'-nucleotidase. (227 aa) |
| | edc3 | Uncharacterized protein. (505 aa) |
| | nags | N-acetylglutamate synthase. (95 aa) |
| | drosha | Kruppel-like factor 8. (1382 aa) |
| | TSEN34 | tRNA-splicing endonuclease subunit Sen34; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structura [...] (308 aa) |
| | rexo5 | Nkx1-1. (787 aa) |
| | meiob | Solute carrier family 12 (potassium/chloride transporter), member 4. (480 aa) |
| | cpsf4l | Novel protein similar to cpsf4. (269 aa) |
| | atad5 | Dipeptidyl-peptidase 6. (1728 aa) |
| | dcp1a | mRNA_decap_C domain-containing protein. (456 aa) |
| | rps21 | 40S ribosomal protein S21; Belongs to the eukaryotic ribosomal protein eS21 family. (83 aa) |
| | LOC100496720 | Notum, palmitoleoyl-protein carboxylesterase. (505 aa) |
| | lactb2 | Endoribonuclease LACTB2; Endoribonuclease; cleaves preferentially 3' to purine- pyrimidine dinucleotide motifs in single-stranded RNA. The cleavage product contains a free 3' -OH group. Has no activity with double- stranded RNA or DNA. Required for normal mitochondrial function and cell viability. (317 aa) |
| | endoul2 | XendoU domain-containing protein. (306 aa) |
| | POP5 | Ribonuclease P/MRP protein subunit POP5; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. (165 aa) |
| | ENSXETP00000051711 | Uncharacterized protein. (252 aa) |
| | LOC100490587 | Hyaluronan binding protein 2. (314 aa) |
| | MGC146443 | Leucine-rich repeat-containing 1. (204 aa) |
| | ENSXETP00000051705 | Uncharacterized protein. (299 aa) |
| | l2hgdh | L-2-hydroxyglutarate dehydrogenase. (214 aa) |
| | ENSXETP00000051695 | Uncharacterized protein. (265 aa) |
| | prorp | Chromosome 1 open reading frame 21. (583 aa) |
| | nudt21 | Nudix hydrolase domain-containing protein. (344 aa) |
| | aen | Exonuclease domain-containing protein. (360 aa) |
| | polg | Tyrosylprotein sulfotransferase 1. (1197 aa) |
| | B4GALNT3 | Beta-1,4-N-acetylgalactosaminyltransferase; Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'- diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans. (787 aa) |
| | rbbp8 | DNA endonuclease RBBP8; Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end resection, the first step of double-strand break (DSB) repair through the homologous recombination (HR) pathway. Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA. (856 aa) |
| | PDE12 | Phosphodiesterase 12. (537 aa) |
| | dcp1b | Chromosome X open reading frame 21. (567 aa) |
| | rnaset2 | Uncharacterized protein; Belongs to the RNase T2 family. (228 aa) |
| | cnot8 | CCR4-NOT transcription complex, subunit 8. (289 aa) |
| | fip1l1 | GRB10 interacting GYF protein 1. (581 aa) |
| | nhp2 | H/ACA ribonucleoprotein complex subunit 2-like protein; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (By similarity). (149 aa) |
| | mgme1 | Mitochondrial genome maintenance exonuclease 1; Single-stranded DNA (ssDNA) metal-dependent exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair. Specifically binds 5-hydroxymethylcytosine (5hmC)-containing DNA in stem cells (By similarity). (347 aa) |
| | dicer1 | Endoribonuclease Dicer; Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, al [...] (1899 aa) |
| | tatdn2 | Uncharacterized protein. (697 aa) |
| | rpp30 | Uncharacterized protein. (303 aa) |
| | ENPP3 | Ectonucleotide pyrophosphatase/phosphodiesterase 3. (828 aa) |
| | exo1 | Ubiquitin-fold modifier conjugating enzyme 1. (736 aa) |
| | polr2i | Solute carrier family 25 member 3. (133 aa) |
| | setmar | Solute carrier family 26 (anion exchanger), member 11. (284 aa) |
| | endog | Endonuclease. (293 aa) |
| | dis3l2 | DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase. Essential for correct mitosis, and negatively regulates cell proliferation. Belongs to the RNR ribonuclease family. DIS3L2 subfamily. (812 aa) |
| | ENPP1 | Ectonucleotide pyrophosphatase/phosphodiesterase 1. (845 aa) |
| | YBEY | YbeY metalloendoribonuclease. (177 aa) |
| | cpsf2 | Cleavage and polyadenylation specificity factor subunit 2. (783 aa) |
| | RNASEK | Ribonuclease K. (101 aa) |
| | dnase2 | Deoxyribonuclease II, lysosomal. (352 aa) |
| | LOC100127659 | Cytosolic Fe-S cluster assembly factor nubp2. (363 aa) |
| | eme1 | ERCC4 domain-containing protein. (317 aa) |
| | vav2-2 | Vav guanine nucleotide exchange factor 2. (221 aa) |
| | cnot6l | Hepatocyte nuclear factor 4 gamma. (587 aa) |
| | ube2d4-2 | Carbohydrate (chondroitin 4) sulfotransferase 12. (420 aa) |
| | nudt12 | Paired like homeobox 2B. (458 aa) |
| | LRRC27 | Leucine rich repeat containing 27. (440 aa) |
| | ago4 | Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs; Belongs to the argonaute family. Ago subfamily. (884 aa) |
| | hsd17b4-2 | Hydroxysteroid (17-beta) dehydrogenase 4. (275 aa) |
| | dnase1l3 | Frizzled class receptor 4. (318 aa) |
| | ercc2 | Epoxide hydrolase 3. (760 aa) |
| | nudt16 | Solute carrier family 45 member 2. (213 aa) |
| | pnpt1 | F-box DNA helicase 1. (789 aa) |
| | zc3h12b | C-terminal binding protein 1. (854 aa) |
| | las1l | Uncharacterized protein. (589 aa) |
| | ago1 | Protein tyrosine phosphatase receptor type S; Belongs to the argonaute family. (880 aa) |
| | dclre1b | Heat shock protein family A (Hsp70) member 5. (517 aa) |
| | aptx | Aprataxin; DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP- NH(2)) and diadenosine tetraphosphate (AppppA), b [...] (347 aa) |
| | ltb4r2-2 | Deoxyribonuclease I. (339 aa) |
| | wrn | Cell death-inducing p53-target protein 1. (1432 aa) |
| | rag1 | V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (584 aa) |
| | noct | CCR4 carbon catabolite repression 4-like (S. cerevisiae). (458 aa) |
| | eri1 | SAP domain-containing protein. (345 aa) |
| | gjb3-2 | Uncharacterized protein. (128 aa) |
| | smg6 | Mitochondrial genome maintenance exonuclease 1. (1392 aa) |
| | mep1a-2 | N-terminal Xaa-Pro-Lys N-methyltransferase 1. (136 aa) |
| | ankle1 | Uncharacterized protein. (1380 aa) |
| | ENSXETP00000035111 | Reverse transcriptase domain-containing protein. (842 aa) |
| | mblac1 | Transglutaminase 1. (226 aa) |
| | helz2 | T-box 21. (1275 aa) |
| | LOC101731382 | Uncharacterized protein. (211 aa) |
| | LOC100495727 | Uncharacterized protein. (191 aa) |
| | pop4 | Ribonuclease P protein subunit p29; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. (223 aa) |
| | rad51c-2 | RECA_2 domain-containing protein. (121 aa) |
| | LOC100497175 | Deoxyribonuclease; Belongs to the DNase I family. (298 aa) |
| | EXD3 | Exonuclease 3'-5' domain containing 3. (675 aa) |
| | Mei4 | Meiotic double-stranded break formation protein 4. (382 aa) |
| | rad1 | RAD1 homolog (S. pombe). (281 aa) |
| | fscn2-2 | Myotubularin related protein 10. (792 aa) |
| | sparc-2 | Secreted protein, acidic, cysteine-rich (osteonectin). (173 aa) |
| | harbi1 | Serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1). (347 aa) |
| | snd1 | Staphylococcal nuclease domain-containing protein; Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. (912 aa) |
| | ENDOD1 | Endonuclease domain containing 1. (448 aa) |
| | rps3 | Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (246 aa) |
| | ERCC4 | ERCC excision repair 4, endonuclease catalytic subunit. (930 aa) |
| | cpsf6 | Glutamate receptor, metabotropic 5. (556 aa) |
| | cstf2 | Minichromosome maintenance complex component 3 associated protein. (522 aa) |
| | exosc7 | Arylsulfatase family member I. (291 aa) |
| | mre11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (709 aa) |
| | pole | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2298 aa) |
| | piwil1 | CD74 molecule; Belongs to the argonaute family. (861 aa) |
| | hepacam2 | Thyroid peroxidase. (572 aa) |
| | trex2 | Protein CWC15 homolog. (230 aa) |
| | ints11 | Uncharacterized protein. (633 aa) |
| | SAMHD1 | SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (630 aa) |
| | cnot2 | Clathrin light chain A. (538 aa) |
| | GEN1 | GEN1 Holliday junction 5' flap endonuclease. (927 aa) |
| | LOC100494905 | Heat shock protein family D (Hsp60) member 1. (269 aa) |
| | EDC4 | Enhancer of mRNA decapping 4. (1383 aa) |
| | dnase1l2 | Deoxyribonuclease; Belongs to the DNase I family. (288 aa) |
| | g3bp1 | Formin homology 2 domain containing 1. (507 aa) |
| | n4bp1 | NEDD4-binding protein 1; Inhibitor of the E3 ubiquitin-protein ligase itch. Belongs to the N4BP1 family. (819 aa) |
| | EXOSC3 | Exosome component 3. (250 aa) |
| | RPP25 | Ribonuclease P and MRP subunit p25. (168 aa) |
| | FANCM | FA complementation group M. (2232 aa) |
| | kri1 | NDUFA4, mitochondrial complex associated. (765 aa) |
| | khnyn | RNase_Zc3h12a domain-containing protein. (841 aa) |
| | Rnase4 | Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1. (178 aa) |
| | psen2-2 | Presenilin 2; Belongs to the pancreatic ribonuclease family. (122 aa) |
| | LOC100496462 | RNAse_Pc domain-containing protein; Belongs to the pancreatic ribonuclease family. (165 aa) |
| | nol9 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit. (639 aa) |
| | ercc5 | Basic immunoglobulin-like variable motif-containing protein. (1395 aa) |
| | piwil2 | Piwi-like protein 2; Endoribonuclease that plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Plays an essential role in meiotic differentiation of spermatocytes, germ cell differentiation and in self-renewal of spermatogonial stem cells. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. During [...] (949 aa) |
| | tfip11 | Tuftelin-interacting protein 11; Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. (761 aa) |
| | dbr1 | Lariat debranching enzyme; Cleaves the 2'-5' phosphodiester linkage at the branch point of lariat intron pre-mRNAs after splicing and converts them into linear molecules that are subsequently degraded. It thereby facilitates ribonucleotide turnover. It may also participate in retrovirus replication via an RNA lariat intermediate in cDNA synthesis (By similarity); Belongs to the lariat debranching enzyme family. (534 aa) |
| | rnaseh1 | Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (302 aa) |
| | enpp2 | Uncharacterized protein. (922 aa) |
| | POP1 | POP1 homolog, ribonuclease P/MRP subunit. (1037 aa) |
| | rida | Heat-responsive protein 12. (139 aa) |
| | tut1 | Speckle targeted PIP5K1A-regulated poly(A) polymerase; Poly(A) polymerase that creates the 3'-poly(A) tail of specific pre-mRNAs. In addition to polyadenylation, it is also required for the 3'-end cleavage of pre-mRNAs: binds to the 3'UTR of targeted pre-mRNAs and promotes the recruitment and assembly of the CPSF complex on the 3'UTR of pre-mRNAs. In addition to adenylyltransferase activity, also has uridylyltransferase activity. However, the ATP ratio is higher than UTP in cells, suggesting that it functions primarily as a poly(A) polymerase (By similarity); Belongs to the DNA polymer [...] (854 aa) |
| | LOC101734301 | STAM binding protein like 1. (365 aa) |
| | toe1 | C3H1-type domain-containing protein. (513 aa) |
| | F6XXJ1_XENTR | DDE Tnp4 domain-containing protein. (281 aa) |
| | ncbp1 | Nuclear cap-binding protein subunit 1; Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5'-end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U sn [...] (791 aa) |
| | xpa | Xeroderma pigmentosum, complementation group. (265 aa) |
| | tdp2 | Tyrosyl-DNA phosphodiesterase 2; DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead- end complexes between DNA and the topoisomerase 2 (top2) active site tyrosine residue. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals. (369 aa) |
| | mthfsd-2 | Methenyltetrahydrofolate synthetase domain containing. (751 aa) |
| | dis3 | Uncharacterized protein; Belongs to the RNR ribonuclease family. (998 aa) |
| | dnase2b | Deoxyribonuclease II beta. (340 aa) |
| | ERI2 | ERI1 exoribonuclease family member 2. (695 aa) |
| | DCLRE1C | DNA cross-link repair 1C. (721 aa) |
| | mus81 | Crossover junction endonuclease MUS81; Interacts with eme1 and eme2 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks (By similarity); Belongs to the XPF family. (612 aa) |
| | polr3k | DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (108 aa) |
| | rad51c | Malignant T-cell-amplified sequence 1. (369 aa) |
| | mrpl44 | Hypothetical LOC496841. (322 aa) |
| | apex1 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (363 aa) |
| | pcf11 | Pcf11 protein. (1698 aa) |
| | rad50 | Toll-like receptor13. (1312 aa) |
| | cnot7 | CCR4-NOT transcription complex subunit 7; Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA- mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence [...] (285 aa) |
| | tdp1 | Uncharacterized protein. (606 aa) |
| | LOC101731854 | Uncharacterized protein. (294 aa) |
| | ern2 | Endoplasmic reticulum to nucleus signaling 2. (957 aa) |
| | chmp2b | Charged multivesicular body protein 2b; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids (By similarity). (225 aa) |
| | zranb3 | RE1 silencing transcription factor. (1081 aa) |
| | ttc38 | Tetratricopeptide repeat protein 38; Belongs to the TTC38 family. (479 aa) |
| | exosc8 | Uncharacterized protein. (276 aa) |
| | eme2 | Probable crossover junction endonuclease EME2; Interacts with mus81 to form a DNA structure-specific endonuclease which cleaves substrates such as 3'-flap structures. (503 aa) |
| | c12orf10 | Melanocyte proliferating gene 1. (369 aa) |
| | rexo4 | RNA exonuclease 4. (414 aa) |
| | RPP38 | Ribonuclease P/MRP subunit p38. (261 aa) |
| | N4BP2 | NEDD4 binding protein 2. (1502 aa) |
| | exosc10-2 | Exosome component 10. (127 aa) |
| | dclre1a | T-box transcription factor TBX1. (960 aa) |
| | tbl3 | Speckle targeted PIP5K1A-regulated poly(A) polymerase. (774 aa) |
| | mybl2 | MYB proto-oncogene like 2. (344 aa) |
| | exd2 | Phospholipase A2 group IB. (642 aa) |
| | ENSXETP00000020723 | DDE Tnp4 domain-containing protein. (346 aa) |
| | ZC3H12C | Zinc finger CCCH-type containing 12C. (884 aa) |
| | nob1 | RNA-binding protein NOB1; May play a role in mRNA degradation. Belongs to the NOB1 family. (436 aa) |
| | ercc1 | Uncharacterized protein. (302 aa) |
| | ENSXETP00000019857 | Uncharacterized protein. (181 aa) |
| | ENSXETP00000019751 | SCAN box domain-containing protein. (762 aa) |
| | spo11 | TP6A_N domain-containing protein. (396 aa) |
| | spopl | Speckle type POZ protein like. (436 aa) |
| | bms1 | Bms1-type G domain-containing protein. (1261 aa) |
| | rexo2 | LRP2 binding protein. (273 aa) |
| | ZNRD1 | DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (122 aa) |
| | ago2 | Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (894 aa) |
| | TATDN1 | TatD DNase domain containing 1. (329 aa) |
| | FAN1 | Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1012 aa) |
| | pan2 | PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent [...] (1210 aa) |
| | rcl1 | SPT6 homolog, histone chaperone. (372 aa) |
| | marf1 | Meiosis regulator and mRNA stability factor 1; Essential regulator of oogenesis required for female meiotic progression to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. (1682 aa) |
| | rrs1 | Rrs1 protein. (123 aa) |
| | ENDOU | Poly(U)-specific endoribonuclease. (418 aa) |
| | ENSXETP00000052624 | Endo/exonuclease/phosphatase domain-containing protein. (437 aa) |
| | ERI3 | ERI1 exoribonuclease family member 3. (321 aa) |
| | ogg1 | Heparan sulfate-glucosamine 3-sulfotransferase 3A1. (431 aa) |
| | Zc3h12a | C3H1-type domain-containing protein. (349 aa) |
| | idi1-2 | Isopentenyl-diphosphate delta isomerase 1. (290 aa) |
| | ENSXETP00000052247 | Endo/exonuclease/phosphatase domain-containing protein. (242 aa) |
| | LOC780277 | Lysophosphatidic acid receptor 2. (297 aa) |
| | nlgn2 | Uncharacterized protein. (299 aa) |
| | LOC100490758 | Uncharacterized protein. (337 aa) |
