(54 nodes) Extrinsic apoptotic signaling pathway network (Xenopus tropicalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	parp2	Poly [ADP-ribose] polymerase. (787 aa)
	acvr1b	Serine/threonine kinase 17a. (530 aa)
	ripk1	Sequestosome 1. (669 aa)
	CASP8AP2	Uncharacterized protein. (1824 aa)
	rb1cc1	45 kDa calcium-binding protein. (1576 aa)
	p2rx7	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (558 aa)
	LOC100490828	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (559 aa)
	pdia3	Protein disulfide-isomerase. (501 aa)
	ITPRIPL2	ITPRIP like 2. (500 aa)
	mcl1	Uncharacterized protein. (283 aa)
	gsk3a	CACN subunit beta associated regulatory protein; Belongs to the protein kinase superfamily. (439 aa)
	NF1	Neurofibromin 1. (2812 aa)
	tlr3	TIR domain-containing protein; Belongs to the Toll-like receptor family. (917 aa)
	krt8.1	Keratin 8; Belongs to the intermediate filament family. (508 aa)
	dedd2	DED domain-containing protein. (356 aa)
	itgav	RAB5B, member RAS oncogene family; Belongs to the integrin alpha chain family. (1034 aa)
	tgfb1	Transforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
	casp2	BCR, RhoGEF and GTPase activating protein; Belongs to the peptidase C14A family. (421 aa)
	fadd	Zinc finger, NFX1-type containing 1, gene 2. (188 aa)
	itprip	Sulfotransferase family cytosolic 2B member 1-like. (539 aa)
	LOC101734414	One cut homeobox 1, gene 2. (229 aa)
	BCL2	BCL2 apoptosis regulator. (293 aa)
	eya2	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (554 aa)
	wwox	RUNX family transcription factor 1. (381 aa)
	FASLG	Fas ligand. (252 aa)
	bcl2l2	Regulator of microtubule dynamics 1. (188 aa)
	bad	SMC5-SMC6 complex localization factor 1. (151 aa)
	tradd	Endoplasmic reticulum aminopeptidase 1. (303 aa)
	bcl2l10	Uncharacterized protein. (174 aa)
	ENSXETP00000051440	Uncharacterized protein. (168 aa)
	fgfr3	Fibroblast growth factor receptor. (829 aa)
	dele1	Uncharacterized protein. (563 aa)
	DAXX	Death domain associated protein. (910 aa)
	mllt11	Kruppel-like factor 3 (basic). (80 aa)
	bok	Plexin A1. (214 aa)
	lnpep	Leucyl/cystinyl aminopeptidase. (101 aa)
	SORT1	Sortilin. (801 aa)
	rnf41	Bardet-Biedl syndrome 5. (317 aa)
	skil	c-SKI_SMAD_bind domain-containing protein. (643 aa)
	PIDD1	P53-induced death domain protein 1. (908 aa)
	tnf	Thyrotropin-releasing hormone receptor 3. (227 aa)
	siva1	Aspartoacylase. (194 aa)
	ddx47	Marker of proliferation Ki-67; Belongs to the DEAD box helicase family. (466 aa)
	ngf	Ribonuclease H2 subunit A; Belongs to the NGF-beta family. (231 aa)
	GSK3B	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (434 aa)
	INHBA	Inhibin subunit beta A. (411 aa)
	rbmx2-2	RNA binding motif protein X-linked 2. (174 aa)
	plpp4-2	Phospholipid phosphatase 4. (563 aa)
	casp10	Casp10 protein; Belongs to the peptidase C14A family. (519 aa)
	casp8	S-adenosylmethionine sensor upstream of mTORC1; Belongs to the peptidase C14A family. (504 aa)
	bcl2l11	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (194 aa)
	bax	BCL2-associated X protein. (221 aa)
	fas	Vitamin D receptor. (320 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (418 aa)

Your Current Organism:

Xenopus tropicalis

NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCL2	DAXX	ENSXETP00000032076	ENSXETP00000047764	BCL2 apoptosis regulator.	Death domain associated protein.	0.534
BCL2	ENSXETP00000051440	ENSXETP00000032076	ENSXETP00000051440	BCL2 apoptosis regulator.	Uncharacterized protein.	0.839
BCL2	FASLG	ENSXETP00000032076	ENSXETP00000035772	BCL2 apoptosis regulator.	Fas ligand.	0.530
BCL2	bad	ENSXETP00000032076	ENSXETP00000036631	BCL2 apoptosis regulator.	SMC5-SMC6 complex localization factor 1.	0.975
BCL2	bax	ENSXETP00000032076	ENSXETP00000009494	BCL2 apoptosis regulator.	BCL2-associated X protein.	0.997
BCL2	bcl2l10	ENSXETP00000032076	ENSXETP00000052849	BCL2 apoptosis regulator.	Uncharacterized protein.	0.565
BCL2	bcl2l11	ENSXETP00000032076	ENSXETP00000007895	BCL2 apoptosis regulator.	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family.	0.997
BCL2	bcl2l2	ENSXETP00000032076	ENSXETP00000036108	BCL2 apoptosis regulator.	Regulator of microtubule dynamics 1.	0.777
BCL2	bok	ENSXETP00000032076	ENSXETP00000044504	BCL2 apoptosis regulator.	Plexin A1.	0.508
BCL2	casp10	ENSXETP00000032076	ENSXETP00000006082	BCL2 apoptosis regulator.	Casp10 protein; Belongs to the peptidase C14A family.	0.516
BCL2	casp2	ENSXETP00000032076	ENSXETP00000024754	BCL2 apoptosis regulator.	BCR, RhoGEF and GTPase activating protein; Belongs to the peptidase C14A family.	0.481
BCL2	casp8	ENSXETP00000032076	ENSXETP00000006109	BCL2 apoptosis regulator.	S-adenosylmethionine sensor upstream of mTORC1; Belongs to the peptidase C14A family.	0.726
BCL2	fadd	ENSXETP00000032076	ENSXETP00000025713	BCL2 apoptosis regulator.	Zinc finger, NFX1-type containing 1, gene 2.	0.477
BCL2	mcl1	ENSXETP00000032076	ENSXETP00000017736	BCL2 apoptosis regulator.	Uncharacterized protein.	0.545
BCL2	plpp4-2	ENSXETP00000032076	ENSXETP00000005725	BCL2 apoptosis regulator.	Phospholipid phosphatase 4.	0.538
BCL2	rbmx2-2	ENSXETP00000032076	ENSXETP00000005718	BCL2 apoptosis regulator.	RNA binding motif protein X-linked 2.	0.538
BCL2	siva1	ENSXETP00000032076	ENSXETP00000002394	BCL2 apoptosis regulator.	Aspartoacylase.	0.911
CASP8AP2	casp10	ENSXETP00000013124	ENSXETP00000006082	Uncharacterized protein.	Casp10 protein; Belongs to the peptidase C14A family.	0.466
CASP8AP2	casp8	ENSXETP00000013124	ENSXETP00000006109	Uncharacterized protein.	S-adenosylmethionine sensor upstream of mTORC1; Belongs to the peptidase C14A family.	0.466
DAXX	BCL2	ENSXETP00000047764	ENSXETP00000032076	Death domain associated protein.	BCL2 apoptosis regulator.	0.534

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