STRINGSTRING
LOC108644694 LOC108644694 DLG5 DLG5 rap2c rap2c stk26 stk26 stc1 stc1 TIE1 TIE1 myocd myocd dcn dcn meox2 meox2 srgap3 srgap3 rap2a rap2a med1 med1 evl evl TNN TNN fam102a fam102a ap3s2 ap3s2 NEXMIF NEXMIF Adora3.3 Adora3.3 adora3 adora3 LOC100496142 LOC100496142 gata3 gata3 ccdc125 ccdc125 rin3 rin3 papolg-2 papolg-2 ptpn23 ptpn23 GDF2 GDF2 atg9a-2 atg9a-2 dag1 dag1 c5orf30 c5orf30 AFDN AFDN RECK RECK foxd1 foxd1 rnf41 rnf41 abhd6 abhd6 naa10 naa10 GPR18 GPR18 cldn5 cldn5 PODN PODN c5 c5 ptprt ptprt dusp10 dusp10 synj2bp synj2bp Ccl27 Ccl27 rabgef1 rabgef1 LOC100488346 LOC100488346 ptger4 ptger4 srgap1 srgap1 slit2 slit2 zmynd8 zmynd8 LOC100498468 LOC100498468 THBS1 THBS1 acvrl1 acvrl1 SERPINE1 SERPINE1 dusp10.2 dusp10.2 Nisch Nisch ap1ar ap1ar SCAI SCAI acvr1c acvr1c CLDN19 CLDN19 BCL2 BCL2 BRAF BRAF rap2b rap2b PTPRM PTPRM ccn3 ccn3 LOC101732357 LOC101732357 tmeff2 tmeff2 nradd nradd fam102b fam102b ptprr ptprr aldh1l1 aldh1l1 eng eng has1l has1l PIP5KL1 PIP5KL1 flcn flcn clic5 clic5 TP53INP1 TP53INP1 srgap2 srgap2 DRD2 DRD2 jup jup adipor1 adipor1 ptprg ptprg osbpl8 osbpl8 cygb cygb LOC779521 LOC779521 marveld3 marveld3 ENSXETP00000021488 ENSXETP00000021488 tgfb1 tgfb1 sulf1 sulf1 wnt11-2 wnt11-2 nedd9 nedd9 adtrp adtrp rgcc rgcc tbx5 tbx5 limch1 limch1 nrg3 nrg3 ADGRG1 ADGRG1 stat3.1 stat3.1 stat3.2 stat3.2 NF1 NF1 cyp1b1 cyp1b1 krit1 krit1 sfrp2 sfrp2 MMRN2 MMRN2 svbp svbp cd74 cd74 jag1 jag1 pdhx-2 pdhx-2 sinhcaf sinhcaf mcc mcc itgb1bp1 itgb1bp1 vash1 vash1 crk crk TNFAIP6 TNFAIP6 THY1 THY1 pin1 pin1 chrd.1 chrd.1 mecp2 mecp2 wnt11 wnt11 spint2 spint2 s1pr2 s1pr2 padi2 padi2 ripor2 ripor2 LOC100135231 LOC100135231 BMP10 BMP10 map2k5 map2k5 mmp28 mmp28 adipoq adipoq gtpbp4 gtpbp4 c1qtnf9b c1qtnf9b gna13 gna13 ARID2 ARID2 adora1 adora1 il27ra il27ra LOC101733520 LOC101733520 wasll wasll LOC101730668 LOC101730668 cnn1 cnn1 STAP1 STAP1 emilin1 emilin1 csnk2b csnk2b tnf tnf ptpru ptpru DLL4 DLL4 cyp1c1 cyp1c1 LOC100495677 LOC100495677 ptprk ptprk dpp4 dpp4 bmerb1 bmerb1 tbxa2r tbxa2r wasl wasl grem1 grem1 gdf5-2 gdf5-2 abhd2 abhd2 nfe2l2 nfe2l2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
LOC108644694Ubiquitin conjugating enzyme E2Q family-like 1. (707 aa)
DLG5Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1971 aa)
rap2cRAP2C, member of RAS oncogene family. (183 aa)
stk26Carboxypeptidase, vitellogenic-like. (440 aa)
stc1Serine/threonine kinase 16. (247 aa)
TIE1Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1131 aa)
myocdYip1 domain family member 1. (956 aa)
dcnDecorin; May affect the rate of fibrils formation. (364 aa)
meox2Meox2 protein. (300 aa)
srgap3RAB39A, member RAS oncogene family. (1096 aa)
rap2aRAP2A, member of RAS oncogene family. (183 aa)
med1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). (1591 aa)
evlSolute carrier family 30 (zinc transporter), member 9. (712 aa)
TNNTenascin N. (1093 aa)
fam102aLOC100036602 protein. (377 aa)
ap3s2Arpin; Regulates actin polymerization by inhibiting the actin- nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors. Involved in steering cell migration by controlling its directional persistence (By similarity). Belongs to the Arpin family. (395 aa)
NEXMIFNeurite extension and migration factor. (1420 aa)
Adora3.3Adenosine receptor A3; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (329 aa)
adora3Adenosine receptor A3; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (313 aa)
LOC100496142Adenosine receptor A3; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (326 aa)
gata3Uncharacterized protein. (454 aa)
ccdc125Uncharacterized protein. (531 aa)
rin3Ribophorin II. (1034 aa)
papolg-2Poly(A) polymerase gamma. (466 aa)
ptpn23Uncharacterized protein. (1915 aa)
GDF2Growth differentiation factor 2. (410 aa)
atg9a-2Autophagy related 9A. (148 aa)
dag1Peptidase S72 domain-containing protein. (885 aa)
c5orf30Macrophage immunometabolism regulator; May play a role in immune regulation through regulation of the macrophage function (By similarity). May also play a role in trafficking of proteins via its interaction with unc119 family cargo adapters (By similarity). May play a role in ciliary membrane localization (By similarity). (205 aa)
AFDNAfadin, adherens junction formation factor. (1876 aa)
RECKReversion inducing cysteine rich protein with kazal motifs. (983 aa)
foxd1Forkhead box protein D1; Transcriptional repressor that down-regulates bmp4 signaling in both mesoderm and ectoderm. Regulates mesoderm patterning by repressing ventral mesoderm genes and promoting the expression of dorsolateral genes. Can also neuralize ectodermal cells directly. Inhibits neural crest migration. The transcription factors foxd1 and foxg1 mutually repress each other to pattern the forebrain (By similarity). (329 aa)
rnf41Bardet-Biedl syndrome 5. (317 aa)
abhd6Tumor protein D52. (344 aa)
naa10Zinc finger protein 37A. (988 aa)
GPR18G protein-coupled receptor 18; Belongs to the G-protein coupled receptor 1 family. (331 aa)
cldn5Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (216 aa)
PODNPodocan. (598 aa)
c5A2M_N_2 domain-containing protein. (958 aa)
ptprtMyotrophin. (1486 aa)
dusp10NPC1 like 1. (464 aa)
synj2bpSynj2bp protein. (145 aa)
Ccl27SCY domain-containing protein. (138 aa)
rabgef1SET nuclear proto-oncogene. (538 aa)
LOC100488346Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1239 aa)
ptger4G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (479 aa)
srgap1Blood vessel epicardial substance. (1093 aa)
slit2ATPase family, AAA domain containing 3A. (1564 aa)
zmynd8Uncharacterized protein. (1216 aa)
LOC100498468Uncharacterized protein. (471 aa)
THBS1Thrombospondin 1. (1188 aa)
acvrl1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (490 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (449 aa)
dusp10.2Uncharacterized protein; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (419 aa)
NischUncharacterized protein. (196 aa)
ap1arEukaryotic translation initiation factor 4E type 3. (291 aa)
SCAISuppressor of cancer cell invasion. (564 aa)
acvr1cReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (537 aa)
CLDN19Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (221 aa)
BCL2BCL2 apoptosis regulator. (293 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (908 aa)
rap2bRAP2B, member of RAS oncogene family. (182 aa)
PTPRMProtein tyrosine phosphatase receptor type M. (1460 aa)
ccn3Superoxide dismutase [Cu-Zn]. (344 aa)
LOC101732357Fer-1-like family member 4, pseudogene (functional). (691 aa)
tmeff2Hydroxysteroid (17-beta) dehydrogenase 10. (354 aa)
nraddHigh mobility group box 3. (390 aa)
fam102bSpi-1 proto-oncogene. (363 aa)
ptprrTyrosine-protein phosphatase domain-containing protein. (643 aa)
aldh1l1Cytosolic 10-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily. (951 aa)
engUncharacterized protein. (622 aa)
has1lHyaluronan synthase 1. (566 aa)
PIP5KL1Phosphatidylinositol-4-phosphate 5-kinase like 1. (477 aa)
flcnFolliculin; Belongs to the folliculin family. (579 aa)
clic5Chloride intracellular channel 4. (252 aa)
TP53INP1Tumor protein p53 inducible nuclear protein 1. (237 aa)
srgap2Uncharacterized protein. (1027 aa)
DRD2G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (440 aa)
jupUncharacterized protein. (750 aa)
adipor1Adiponectin receptor 1. (379 aa)
ptprgTranscription factor A, mitochondrial. (654 aa)
osbpl8Oxysterol-binding protein; Belongs to the OSBP family. (966 aa)
cygbCytoglobin; Belongs to the globin family. (179 aa)
LOC779521BMERB domain-containing protein. (276 aa)
marveld3Mannan-binding lectin serine peptidase 2. (453 aa)
ENSXETP00000021488Uncharacterized protein. (877 aa)
tgfb1Transforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
sulf1Uncharacterized protein. (1145 aa)
wnt11-2Protein Wnt-11; Ligand for members of the frizzled family of seven transmembrane receptors (By similarity). Shares much functionality with wnt11b. Signals through a non-canonical Wnt pathway to activate Jun-N- terminal kinase (JNK) to regulate gastrulation movements. Acts in a non-cell-autonomous manner to control neural crest migration, probably acting as an extracellular signal from surrounding tissue, but is not required for neural crest induction. Acts redundantly with wnt11b during pronephros induction. Regulates cardiac morphogenesis through the activation of JNK, but is not requ [...] (352 aa)
nedd9Sterol regulatory element binding transcription factor 1. (782 aa)
adtrpB cell linker. (235 aa)
rgccDual specificity phosphatase 11 (RNA/RNP complex 1-interacting), gene 2. (128 aa)
tbx5T-box transcription factor TBX5; DNA-binding protein that regulates the transcription of several genes and is involved in heart development and limb pattern formation. May bind to the core DNA motif of promoters. (520 aa)
limch1Target of myb1 like 2 membrane trafficking protein. (1897 aa)
nrg3Dachshund family transcription factor 1. (658 aa)
ADGRG1Adhesion G protein-coupled receptor G1; Belongs to the G-protein coupled receptor 2 family. (744 aa)
stat3.1Signal transducer and activator of transcription. (715 aa)
stat3.2STAT_int domain-containing protein. (408 aa)
NF1Neurofibromin 1. (2812 aa)
cyp1b1Uncharacterized protein; Belongs to the cytochrome P450 family. (550 aa)
krit1Uncharacterized protein. (744 aa)
sfrp2Secreted frizzled-related protein 2. (295 aa)
MMRN2Multimerin 2. (765 aa)
svbpProteasome subunit alpha 7. (66 aa)
cd74Synovial sarcoma translocation gene on chromosome 18-like 1. (291 aa)
jag1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
pdhx-2Oxysterol binding protein like 10. (49 aa)
sinhcafEstrogen receptor binding site associated, antigen, 9. (215 aa)
mccUncharacterized protein. (1006 aa)
itgb1bp1Ficolin 1. (209 aa)
vash1Serine incorporator 5. (346 aa)
crkMultivesicular body subunit 12B. (297 aa)
TNFAIP6TNF alpha induced protein 6. (269 aa)
THY1Thy-1 cell surface antigen. (136 aa)
pin1Peptidyl-prolyl cis-trans isomerase. (159 aa)
chrd.1Chordin; Belongs to the chordin family. (942 aa)
mecp2Kruppel-like factor 17. (466 aa)
wnt11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
spint2Novel protein similar to spint2 (serine protease inhibitor, Kunitz type, 2). (394 aa)
s1pr2tRNA selenocysteine 1 associated protein 1. (349 aa)
padi2Uncharacterized protein. (421 aa)
ripor2PL48 domain-containing protein. (1063 aa)
LOC100135231Ring finger protein 166. (328 aa)
BMP10Bone morphogenetic protein 10. (421 aa)
map2k5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (448 aa)
mmp28Pleckstrin homology and RhoGEF domain containing G1. (510 aa)
adipoqCollagen, type VII, alpha 1 (Epidermolysis bullosa, dystrophic, dominant and recessive). (235 aa)
gtpbp4Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. (633 aa)
c1qtnf9bHECT domain containing E3 ubiquitin protein ligase 3. (244 aa)
gna13LOC100145489 protein. (377 aa)
ARID2AT-rich interaction domain 2. (1816 aa)
adora1Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (326 aa)
il27raUncharacterized protein. (473 aa)
LOC101733520C-C motif chemokine. (91 aa)
wasllCut like homeobox 1. (404 aa)
LOC101730668ABC transporter domain-containing protein. (310 aa)
cnn1Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. (296 aa)
STAP1Signal transducing adaptor family member 1. (216 aa)
emilin1Uncharacterized protein. (1057 aa)
csnk2bCasein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (215 aa)
tnfThyrotropin-releasing hormone receptor 3. (227 aa)
ptpru5'-nucleotidase domain containing 4. (1433 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (679 aa)
cyp1c1Smad nuclear interacting protein 1; Belongs to the cytochrome P450 family. (524 aa)
LOC100495677WD repeat domain 7. (337 aa)
ptprkEstrogen related receptor gamma. (1462 aa)
dpp4Uncharacterized protein; Belongs to the peptidase S9B family. (837 aa)
bmerb1Metastasis suppressor 1, gene 1. (206 aa)
tbxa2rLOC100145351 protein. (371 aa)
waslWiskott-Aldrich syndrome-like. (511 aa)
grem1Gremlin. (182 aa)
gdf5-2Growth differentiation factor 5. (1420 aa)
abhd2Mitochondrial ribosomal protein L37. (443 aa)
nfe2l2Similar to nfe2l2 (Nuclear factor (Erythroid-derived 2)-like 2). (589 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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