STRINGSTRING
LOC100490493 LOC100490493 tspo tspo pid1 pid1 LOC100490663 LOC100490663 romo1 romo1 ACOD1 ACOD1 f2 f2 THBS1 THBS1 syk syk rnf41 rnf41 ENSXETP00000040724 ENSXETP00000040724 tp53 tp53 cyba cyba nfe2l2 nfe2l2 idi1-2 idi1-2 hipk2-2 hipk2-2 Zc3h12a Zc3h12a LOC108648908 LOC108648908 cyp1c1 cyp1c1 LOC100490060 LOC100490060 acod1lb acod1lb tgfbr2 tgfbr2 cyp1b1 cyp1b1 pdgfb-2 pdgfb-2 sec62-2 sec62-2 tgfb1 tgfb1 ifnl2 ifnl2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC100490493Coiled-coil-helix-coiled-coil-helix domain containing 2; Belongs to the protein kinase superfamily. (421 aa)
tspoDLC1 Rho GTPase activating protein. (243 aa)
pid1IlvB (bacterial acetolactate synthase)-like. (222 aa)
LOC100490663Uncharacterized protein; Belongs to the protein kinase superfamily. (439 aa)
romo1Reactive oxygen species modulator 1; Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage (By similarity). (79 aa)
ACOD1Aconitate decarboxylase 1. (474 aa)
f2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (607 aa)
THBS1Thrombospondin 1. (1188 aa)
sykTyrosine-protein kinase. (611 aa)
rnf41Bardet-Biedl syndrome 5. (317 aa)
ENSXETP00000040724Uncharacterized protein. (329 aa)
tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (362 aa)
cybaCytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (187 aa)
nfe2l2Similar to nfe2l2 (Nuclear factor (Erythroid-derived 2)-like 2). (589 aa)
idi1-2Isopentenyl-diphosphate delta isomerase 1. (290 aa)
hipk2-2Homeodomain interacting protein kinase 2. (434 aa)
Zc3h12aC3H1-type domain-containing protein. (349 aa)
LOC108648908Pentaxin. (221 aa)
cyp1c1Smad nuclear interacting protein 1; Belongs to the cytochrome P450 family. (524 aa)
LOC100490060CD274 molecule. (498 aa)
acod1lbCentromere protein K. (498 aa)
tgfbr2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (728 aa)
cyp1b1Uncharacterized protein; Belongs to the cytochrome P450 family. (550 aa)
pdgfb-2Frizzled related protein; Belongs to the PDGF/VEGF growth factor family. (240 aa)
sec62-2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (461 aa)
tgfb1Transforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
ifnl2Type III interferon 5. (179 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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