STRINGSTRING
tp53 tp53 ripk1 ripk1 pum1 pum1 fmr1 fmr1 stat3.2 stat3.2 dhx9 dhx9 stat3.1 stat3.1 Il6 Il6 limd1 limd1 PUM2 PUM2 TRUB1 TRUB1 fxr1 fxr1 ddx5 ddx5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (362 aa)
ripk1Sequestosome 1. (669 aa)
pum1Autophagy/beclin-1 regulator 1. (1171 aa)
fmr1Synaptic functional regulator FMR1; Multifunctional polyribosome-associated RNA-binding protein that plays a central role in neuronal development and synaptic plasticity through the regulation of alternative mRNA splicing, mRNA stability, mRNA dendritic transport and postsynaptic local protein synthesis of a subset of mRNAs. Binds poly(G) and poly(U), and to a lower extent poly(A) and poly(C). ECO:0000250|UniProtKB:P51113, ECO:0000250|UniProtKB:Q06787. (590 aa)
stat3.2STAT_int domain-containing protein. (408 aa)
dhx9U4/U6 small nuclear ribonucleoprotein Prp31. (1257 aa)
stat3.1Signal transducer and activator of transcription. (715 aa)
Il6Uncharacterized protein. (150 aa)
limd1LIM domain-containing protein 1; Acts as a transcriptional corepressor for snai1 and snai2/slug and plays a role in regulating neural crest development. (589 aa)
PUM2Pumilio RNA binding family member 2. (1192 aa)
TRUB1TruB pseudouridine synthase family member 1. (291 aa)
fxr1Fragile X mental retardation syndrome-related protein 1 homolog; RNA-binding protein. Binds poly(G) and poly(U) but not poly(A) or poly(C). Regulates somite formation, probably by regulating gene expression (By similarity). (674 aa)
ddx5Uncharacterized protein; Belongs to the DEAD box helicase family. (618 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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