(65 nodes) Extrinsic component of plasma membrane network (Xenopus tropicalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	serpine2	SERPIN domain-containing protein; Belongs to the serpin family. (424 aa)
	picalm	Fukutin. (722 aa)
	rcbtb2-2	Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (1129 aa)
	CDH7	Cadherin 7; Cadherins are calcium-dependent cell adhesion proteins. (783 aa)
	stac3	SH3 and cysteine-rich domain-containing protein 3; Required for normal excitation-contraction coupling in skeletal muscle and for normal muscle contraction in response to membrane depolarization. Required for normal Ca(2+) release from the sarcplasmic reticulum, which ultimately leads to muscle contraction. Probably functions via its effects on muscle calcium channels. Increases CACNA1S channel activity, in addition to its role in enhancing the expression of CACNA1S at the cell membrane. Has a redundant role in promoting the expression of the calcium channel CACNA1S at the cell membrane. (346 aa)
	vbp1-2	Reverse transcriptase domain-containing protein. (1129 aa)
	gngt2.1	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
	gng7	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
	vbp1	Prefoldin subunit 3; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins; Belongs to the prefoldin subunit alpha family. (192 aa)
	snap91	ENTH domain-containing protein. (909 aa)
	kctd1	Potassium channel tetramerization domain containing 1. (302 aa)
	cdkn2d-2	Cyclin-dependent kinase inhibitor 2D. (1011 aa)
	sytl3	HERV-H LTR-associating 2. (206 aa)
	cdh11	Solute carrier family 4 member 11; Cadherins are calcium-dependent cell adhesion proteins. (801 aa)
	gnaz	CCR4-NOT transcription complex subunit 9. (355 aa)
	cdk17	Ameloblastin. (520 aa)
	cdk16	G3BP stress granule assembly factor 2. (522 aa)
	snx9	Sorting nexin. (585 aa)
	FES	Tyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
	gngt1	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
	fmr1	Synaptic functional regulator FMR1; Multifunctional polyribosome-associated RNA-binding protein that plays a central role in neuronal development and synaptic plasticity through the regulation of alternative mRNA splicing, mRNA stability, mRNA dendritic transport and postsynaptic local protein synthesis of a subset of mRNAs. Binds poly(G) and poly(U), and to a lower extent poly(A) and poly(C). ECO:0000250\|UniProtKB:P51113, ECO:0000250\|UniProtKB:Q06787. (590 aa)
	kpna2	Importin subunit alpha; Belongs to the importin alpha family. (528 aa)
	kpna7	Importin subunit alpha; Belongs to the importin alpha family. (523 aa)
	stoml2	PHB domain-containing protein. (341 aa)
	gnb3	Zinc finger, BED-type-containing 8. (349 aa)
	myzap	Myocardial zonula adherens protein; Belongs to the MYZAP family. (519 aa)
	epn3	Acyl-CoA dehydrogenase short chain. (603 aa)
	CDH10	Cadherin 10; Cadherins are calcium-dependent cell adhesion proteins. (787 aa)
	cdh6	Solute carrier family 35 member G1; Cadherins are calcium-dependent cell adhesion proteins. (794 aa)
	rgs1	Regulator of G-protein signaling 1; Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the N-formylpeptide chemoattractant receptors and leukotriene receptors. Inhibits B cell chemotaxis (By similarity). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (By similarity). (201 aa)
	TLN1	Talin 1. (1813 aa)
	gng13	Guanine nucleotide binding protein (G protein), gamma 13. (67 aa)
	syap1	Synapse associated protein 1, SAP47 homolog. (364 aa)
	gnb1	Guanine nucleotide binding protein (G protein), beta polypeptide 2. (340 aa)
	plekha4	N-alpha-acetyltransferase 50. (1470 aa)
	gnas	ATPase family AAA domain-containing protein 1. (292 aa)
	nodal3.1	Nodal homolog 3, gene 1. (75 aa)
	gna15	BCL2 associated athanogene 4. (256 aa)
	CDH24	Cadherin 24; Cadherins are calcium-dependent cell adhesion proteins. (623 aa)
	dnaja3	Uncharacterized protein. (506 aa)
	LOC100486361	Uncharacterized protein. (941 aa)
	cemip	Reverse transcriptase domain-containing protein. (1129 aa)
	sytl1	Synaptotagmin-like 2. (518 aa)
	aak1	Protein kinase domain-containing protein. (1251 aa)
	cdh5	Zinc finger RNA-binding protein; Cadherins are calcium-dependent cell adhesion proteins. (772 aa)
	errfi1	CD53 molecule. (404 aa)
	gnb4	LOC549706 protein. (327 aa)
	ADAMTS10	ADAM metallopeptidase with thrombospondin type 1 motif 10. (1085 aa)
	trpc6	Nucleoporin NUP188 homolog; Belongs to the transient receptor (TC 1.A.4) family. (882 aa)
	gng2	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (145 aa)
	sytl2	Solute carrier family 41 member 1. (2819 aa)
	ENSXETP00000040067	Reverse transcriptase domain-containing protein. (1129 aa)
	nptx2	Nptx2 protein. (439 aa)
	xylt2	Uncharacterized protein. (837 aa)
	bambi	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
	farp1	Mucin 6, oligomeric mucus/gel-forming. (1040 aa)
	WNT2B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (392 aa)
	ctsf-2	Cathepsin F. (1108 aa)
	rnaset2	Uncharacterized protein; Belongs to the RNase T2 family. (228 aa)
	WNT2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
	gngt2	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
	tdgf1.3	Cripto, FRL-1, cryptic family 1. (190 aa)
	tdgf1.1	EGF-like domain-containing protein. (174 aa)
	gnb5	TATA-box binding protein associated factor 13. (395 aa)
	ENSXETP00000053920	Reverse transcriptase domain-containing protein. (1129 aa)

Your Current Organism:

Xenopus tropicalis

NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
aak1	picalm	ENSXETP00000029804	ENSXETP00000000033	Protein kinase domain-containing protein.	Fukutin.	0.525
aak1	snap91	ENSXETP00000029804	ENSXETP00000007048	Protein kinase domain-containing protein.	ENTH domain-containing protein.	0.525
epn3	picalm	ENSXETP00000020710	ENSXETP00000000033	Acyl-CoA dehydrogenase short chain.	Fukutin.	0.433
epn3	snap91	ENSXETP00000020710	ENSXETP00000007048	Acyl-CoA dehydrogenase short chain.	ENTH domain-containing protein.	0.433
epn3	snx9	ENSXETP00000020710	ENSXETP00000014055	Acyl-CoA dehydrogenase short chain.	Sorting nexin.	0.431
gna15	gnb1	ENSXETP00000027610	ENSXETP00000026018	BCL2 associated athanogene 4.	Guanine nucleotide binding protein (G protein), beta polypeptide 2.	0.523
gna15	gnb3	ENSXETP00000027610	ENSXETP00000017645	BCL2 associated athanogene 4.	Zinc finger, BED-type-containing 8.	0.523
gna15	gnb4	ENSXETP00000027610	ENSXETP00000034908	BCL2 associated athanogene 4.	LOC549706 protein.	0.523
gna15	gnb5	ENSXETP00000027610	ENSXETP00000052823	BCL2 associated athanogene 4.	TATA-box binding protein associated factor 13.	0.523
gna15	gng2	ENSXETP00000027610	ENSXETP00000038517	BCL2 associated athanogene 4.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.412
gnas	gnb1	ENSXETP00000027187	ENSXETP00000026018	ATPase family AAA domain-containing protein 1.	Guanine nucleotide binding protein (G protein), beta polypeptide 2.	0.921
gnas	gnb3	ENSXETP00000027187	ENSXETP00000017645	ATPase family AAA domain-containing protein 1.	Zinc finger, BED-type-containing 8.	0.805
gnas	gnb4	ENSXETP00000027187	ENSXETP00000034908	ATPase family AAA domain-containing protein 1.	LOC549706 protein.	0.865
gnas	gnb5	ENSXETP00000027187	ENSXETP00000052823	ATPase family AAA domain-containing protein 1.	TATA-box binding protein associated factor 13.	0.777
gnas	gng13	ENSXETP00000027187	ENSXETP00000024170	ATPase family AAA domain-containing protein 1.	Guanine nucleotide binding protein (G protein), gamma 13.	0.692
gnas	gng2	ENSXETP00000027187	ENSXETP00000038517	ATPase family AAA domain-containing protein 1.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.880
gnas	gng7	ENSXETP00000027187	ENSXETP00000004327	ATPase family AAA domain-containing protein 1.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.524
gnas	gngt1	ENSXETP00000027187	ENSXETP00000014749	ATPase family AAA domain-containing protein 1.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.529
gnas	gngt2	ENSXETP00000027187	ENSXETP00000049752	ATPase family AAA domain-containing protein 1.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.523
gnas	gngt2.1	ENSXETP00000027187	ENSXETP00000003554	ATPase family AAA domain-containing protein 1.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.523

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