STRINGSTRING
ENSXETP00000016475 ENSXETP00000016475 itm2b itm2b renbp renbp sar1a sar1a slc32a1 slc32a1 FRMPD4 FRMPD4 rab9a rab9a atp6v0c atp6v0c tpst1-2 tpst1-2 abcg2 abcg2 foxp4 foxp4 SORT1 SORT1 ehmt1-2 ehmt1-2 MAP3K7 MAP3K7 pdcd6 pdcd6 sycn-2 sycn-2 FIG4 FIG4 clk1 clk1 rgs14 rgs14 pigk pigk FRMPD3 FRMPD3 rexo1 rexo1 irf3 irf3 vamp4 vamp4 ankle1 ankle1 LOC100493529 LOC100493529 ptch1 ptch1 cdip1 cdip1 necap2 necap2 atp6v1d atp6v1d lamtor1 lamtor1 cradd.2-2 cradd.2-2 aldh1a1 aldh1a1 oca2 oca2 INPPL1 INPPL1 LHFPL2 LHFPL2 scamp1 scamp1 clcn3 clcn3 slc11a1 slc11a1 lamtor5 lamtor5 AP3B1 AP3B1 rab35l rab35l cope cope BRAF BRAF rab31 rab31 RPH3A RPH3A dct dct ptk2b ptk2b pld2 pld2 aftph aftph rab3a rab3a pikfyve pikfyve stbd1 stbd1 cpe cpe dipk2a dipk2a plvap plvap VPS13B VPS13B vamp1 vamp1 LOC100495031 LOC100495031 slc30a6-2 slc30a6-2 arrdc3 arrdc3 crp.2 crp.2 slc17a7 slc17a7 vopp1 vopp1 syp syp acy3-2 acy3-2 SNX8 SNX8 ap1b1 ap1b1 sec24b sec24b slc29a3 slc29a3 LOC100496796 LOC100496796 LOC100491292 LOC100491292 slc22a4 slc22a4 dnajc5g dnajc5g SYNPR SYNPR sycn sycn LOC100491589 LOC100491589 KLHL12 KLHL12 lamp1 lamp1 ZPLD1 ZPLD1 doc2b doc2b colgalt2 colgalt2 lamp3 lamp3 Doc2a Doc2a dnm1l dnm1l cdx1-2 cdx1-2 tyr tyr ap2m1 ap2m1 rab38 rab38 ENSXETP00000022077 ENSXETP00000022077 slc17a6 slc17a6 NECAP1 NECAP1 dbh dbh cep135 cep135 slc18a3 slc18a3 epn3 epn3 ap2s1 ap2s1 lamp5 lamp5 copg1 copg1 cgref1 cgref1 sec24a sec24a rab3b rab3b cdkn2aipnl cdkn2aipnl exph5 exph5 or9q2 or9q2 TEPSIN TEPSIN cyb561 cyb561 arcn1 arcn1 slc39a14 slc39a14 atp6v1a atp6v1a crp crp wdr86 wdr86 syt4 syt4 sar1b sar1b tmem163 tmem163 STXBP5L STXBP5L pphln1 pphln1 PSPC1 PSPC1 ap3b2 ap3b2 AP1G1 AP1G1 gpr107-3 gpr107-3 clint1-2 clint1-2 olah olah trim72 trim72 copz1 copz1 pip4p1 pip4p1 slc12a6 slc12a6 dennd1a dennd1a copb2 copb2 vti1b vti1b SYNRG SYNRG entpd7 entpd7 ap1m1 ap1m1 tmem184a tmem184a LOC100486739 LOC100486739 ap1m2 ap1m2 prl.2-2 prl.2-2 ap2b1 ap2b1 AFTPH AFTPH LOC100144286 LOC100144286 ap1g2 ap1g2 phactr2 phactr2 neu3 neu3 pld3 pld3 stx10 stx10 sec31a sec31a epn1 epn1 slc45a2 slc45a2 LOC100496061 LOC100496061 cd276 cd276 SYT11 SYT11 slc45a1 slc45a1 ENSXETP00000011813 ENSXETP00000011813 syn2 syn2 rab9b rab9b DAB2 DAB2 higd1a-2 higd1a-2 rab26 rab26 anxa3 anxa3 SEC31B SEC31B vps45 vps45 snx9 snx9 LOC100494227 LOC100494227 tubgcp2 tubgcp2 ABCA3 ABCA3 sv2a sv2a tcp11l2-2 tcp11l2-2 zfyve28 zfyve28 sec23b sec23b GABRA2 GABRA2 sv2c sv2c EMILIN2 EMILIN2 ap2a1 ap2a1 rab35 rab35 clba1 clba1 znf609 znf609 ocrl ocrl epn2 epn2 syt1 syt1 kcp kcp ccdc136 ccdc136 pip4p2 pip4p2 copg2 copg2 SLC35B4 SLC35B4 slc45a4 slc45a4 INPP5B INPP5B ZFAND1 ZFAND1 tuba3e tuba3e tuba4 tuba4 pef1 pef1 KCNV2 KCNV2 sec23a sec23a litaf litaf npas3 npas3 CLEC16A CLEC16A DNAJC5B DNAJC5B scg3 scg3 atp6v0b atp6v0b abcb6 abcb6 RAB3C RAB3C sv2b sv2b mreg mreg ap4m1 ap4m1 COPZ2 COPZ2 prr15l prr15l rab5a rab5a trarg1 trarg1 SLC17A8 SLC17A8 gad2 gad2 LOC101732697 LOC101732697 coro6 coro6 tmtc2-2 tmtc2-2 tyrp1 tyrp1 rab32 rab32 miga1 miga1 prrt1 prrt1 lamtor3-like lamtor3-like chmp4b chmp4b ENSXETP00000047030 ENSXETP00000047030 wdr91 wdr91 scarb2 scarb2 psap-2 psap-2 tgm2-2 tgm2-2 nampt nampt copa copa LOC100492396 LOC100492396 chmp5 chmp5 coro1c coro1c gpr143 gpr143 syn3 syn3 pam pam RASSF9 RASSF9 smc2-2 smc2-2 rab3d rab3d lamtor2 lamtor2 ap2a2 ap2a2 sulf2 sulf2 tmem184b tmem184b stx6 stx6 vma21 vma21 SYTL4 SYTL4 LOC100036702 LOC100036702 bri3 bri3 chmp7 chmp7
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
ENSXETP00000016475Uncharacterized protein. (193 aa)
itm2bIntegral membrane protein 2B. (257 aa)
renbpCoenzyme Q8B. (414 aa)
sar1aLectin, galactoside-binding, soluble, 4, gene 2; Belongs to the small GTPase superfamily. SAR1 family. (198 aa)
slc32a1Vesicular inhibitory amino acid transporter; Involved in the uptake of GABA and glycine into the synaptic vesicles; Belongs to the amino acid/polyamine transporter 2 family. (518 aa)
FRMPD4FERM and PDZ domain containing 4. (1292 aa)
rab9aVasodilator stimulated phosphoprotein. (201 aa)
atp6v0cV-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (156 aa)
tpst1-2Nocturnin. (447 aa)
abcg2Calcium and integrin binding 1. (660 aa)
foxp4T-box transcription factor TBX20. (658 aa)
SORT1Sortilin. (801 aa)
ehmt1-2Uncharacterized protein. (207 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7. (594 aa)
pdcd6Programmed cell death 6. (182 aa)
sycn-2LOC100127766 protein. (131 aa)
FIG4FIG4 phosphoinositide 5-phosphatase. (741 aa)
clk1Dickkopf WNT signaling pathway inhibitor 3; Belongs to the protein kinase superfamily. (481 aa)
rgs14Regulator of G protein signaling 14. (746 aa)
pigkGPI-anchor transamidase; Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein. Belongs to the peptidase C13 family. (427 aa)
FRMPD3FERM and PDZ domain containing 3. (1608 aa)
rexo1Crystallin beta A2. (1129 aa)
irf3Transmembrane 6 superfamily member 2. (470 aa)
vamp4Vesicle-associated membrane protein 4. (141 aa)
ankle1Uncharacterized protein. (1380 aa)
LOC100493529Leucine zipper protein 2. (425 aa)
ptch1Patched 1. (339 aa)
cdip1Cell death-inducing p53-target protein 1; May act as a p53/TP53-apoptotic effector. (207 aa)
necap2DUF1681 domain-containing protein. (154 aa)
atp6v1dVasculin. (247 aa)
lamtor1Ragulator complex protein LAMTOR1; Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids. May play a role in late endosomes/lysosomes biogenesis and regulate both the recycling of receptors through endosomes and the MAPK signaling pathway. May be involved in cholesterol homeostasis. May also play a role in RHOA activation (By similarity). (157 aa)
cradd.2-2Phospholipase A2 group III. (137 aa)
aldh1a1Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (526 aa)
oca2cAMP responsive element binding protein 1. (858 aa)
INPPL1Inositol polyphosphate phosphatase like 1. (925 aa)
LHFPL2LHFPL tetraspan subfamily member 2. (225 aa)
scamp1Secretory carrier-associated membrane protein. (355 aa)
clcn3Chloride channel protein. (867 aa)
slc11a1T-box 4. (340 aa)
lamtor5Ragulator complex protein LAMTOR5; Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids (By similarity). (91 aa)
AP3B1AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (1097 aa)
rab35lUncharacterized protein. (201 aa)
copeCoatomer subunit epsilon; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Belongs to the COPE family. (315 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (908 aa)
rab31Non-SMC condensin I complex subunit D2. (206 aa)
RPH3ARabphilin 3A. (693 aa)
dctUncharacterized protein. (518 aa)
ptk2bUncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1017 aa)
pld2Phospholipase. (985 aa)
aftphTransmembrane protein 104. (131 aa)
rab3aRAB3A, member RAS oncogene family. (220 aa)
pikfyveUncharacterized protein. (2104 aa)
stbd1CBM20 domain-containing protein. (418 aa)
cpeUncharacterized protein. (467 aa)
dipk2aDivergent protein kinase domain 2A; May play a role in cardiomyocyte proliferation through paracrine signaling and activation of the PPI3K-AKT-CDK7 signaling cascade; Belongs to the DIPK family. (431 aa)
plvapUncharacterized protein. (366 aa)
VPS13BVacuolar protein sorting 13 homolog B. (4027 aa)
vamp1Isocitrate dehydrogenase 1 (NADP+). (110 aa)
LOC100495031Uncharacterized protein. (779 aa)
slc30a6-2Zinc transporter 6. (1103 aa)
arrdc3Tetratricopeptide repeat protein 30A. (412 aa)
crp.2Pentaxin. (240 aa)
slc17a7Vesicular glutamate transporter 1; Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells; Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily. (594 aa)
vopp1Vesicular, overexpressed in cancer, prosurvival protein 1; May be involved in the transcriptional activity of NFKB1. Belongs to the VOPP1/ECOP family. (167 aa)
sypLOC100144928 protein. (300 aa)
acy3-2N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming). (340 aa)
SNX8Sorting nexin 8. (432 aa)
ap1b1AP complex subunit beta. (946 aa)
sec24bCaM kinase-like vesicle-associated. (1103 aa)
slc29a3Uncharacterized protein. (254 aa)
LOC100496796Stonin 2. (367 aa)
LOC100491292Xyloside xylosyltransferase 1. (798 aa)
slc22a4MFS domain-containing protein. (555 aa)
dnajc5gDIRAS family GTP binding RAS like 1. (232 aa)
SYNPRSynaptoporin. (283 aa)
sycnPhosphodiesterase 5A. (131 aa)
LOC100491589RabBD domain-containing protein. (357 aa)
KLHL12Kelch like family member 12. (599 aa)
lamp1Uncharacterized protein. (429 aa)
ZPLD1Zona pellucida like domain containing 1. (407 aa)
doc2bDouble C2-like domain-containing protein. (402 aa)
colgalt2Uncharacterized protein. (616 aa)
lamp3Uncharacterized protein. (309 aa)
Doc2aC2 domain-containing protein. (62 aa)
dnm1lUncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (735 aa)
cdx1-2Tyrosinase_Cu-bd domain-containing protein. (299 aa)
tyrUncharacterized protein. (531 aa)
ap2m1AP-2 complex subunit mu; Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. AP50 is a subunit of the plasma membrane adaptor. The complex binds polyphosphoinositide- containing lipids (By similarity). (437 aa)
rab38Glutathione peroxidase 1. (212 aa)
ENSXETP00000022077Uncharacterized protein. (483 aa)
slc17a6LDL receptor related protein associated protein 1. (583 aa)
NECAP1NECAP endocytosis associated 1. (252 aa)
dbhEctodermal-neural cortex (with BTB-like domain), gene 2. (615 aa)
cep135Centrosomal protein 135kDa. (340 aa)
slc18a3MFS domain-containing protein. (524 aa)
epn3Acyl-CoA dehydrogenase short chain. (603 aa)
ap2s1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (157 aa)
lamp5Lysosome-associated membrane glycoprotein 5; Plays a role in short-term synaptic plasticity in a subset of GABAergic neurons in the brain. (276 aa)
copg1Coatomer subunit gamma; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (874 aa)
cgref1Uncharacterized protein. (253 aa)
sec24aElastin microfibril interfacer 1. (1122 aa)
rab3bRab3b protein. (217 aa)
cdkn2aipnlLysophosphatidylcholine acyltransferase 1. (93 aa)
exph5Fibrillin 3. (1692 aa)
or9q2Uncharacterized protein. (839 aa)
TEPSINTEPSIN adaptor related protein complex 4 accessory protein. (563 aa)
cyb561Laminin subunit alpha 5. (246 aa)
arcn1Coatomer subunit delta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (545 aa)
slc39a14Zinc transporter ZIP14; Broad-scope metal ion transporter with a preference for zinc uptake. Also mediates cellular uptake of nontransferrin-bound iron. (470 aa)
atp6v1aGlypican 5. (596 aa)
crpPentaxin. (234 aa)
wdr86Failed axon connections homolog. (415 aa)
syt4Uncharacterized protein. (424 aa)
sar1bMGC108053 protein; Belongs to the small GTPase superfamily. SAR1 family. (198 aa)
tmem163B-TFIID TATA-box binding protein associated factor 1. (281 aa)
STXBP5LSyntaxin binding protein 5 like. (1236 aa)
pphln1Zinc finger DHHC-type containing 8. (346 aa)
PSPC1Paraspeckle component 1. (517 aa)
ap3b2AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (1106 aa)
AP1G1AP-1 complex subunit gamma. (815 aa)
gpr107-3Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (240 aa)
clint1-2CDGSH iron sulfur domain 1. (1037 aa)
olahNuclear receptor subfamily 2 group C member 2. (254 aa)
trim72Tripartite motif-containing protein 72; Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)- depen [...] (477 aa)
copz1Coatomer subunit zeta; The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex. (177 aa)
pip4p1Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (327 aa)
slc12a6Interleukin 4 induced 1. (1159 aa)
dennd1aTec protein tyrosine kinase. (904 aa)
copb2Coatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (920 aa)
vti1bt-SNARE coiled-coil homology domain-containing protein. (221 aa)
SYNRGSynergin gamma. (1129 aa)
entpd7Ectonucleoside triphosphate diphosphohydrolase 7; Preferentially hydrolyzes nucleoside 5'-triphosphates. The order of activity with respect to possible substrates is UTP > GTP > CTP (By similarity). (617 aa)
ap1m1AP-1 complex subunit mu-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. (455 aa)
tmem184aSEC14-like protein 5. (434 aa)
LOC100486739Pentaxin. (230 aa)
ap1m2AP-1 complex subunit mu-2; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. (426 aa)
prl.2-2Uncharacterized protein. (340 aa)
ap2b1AP complex subunit beta. (970 aa)
AFTPHClathrin_bdg domain-containing protein. (868 aa)
LOC100144286LOC100144286 protein. (362 aa)
ap1g2AP-1 complex subunit gamma. (787 aa)
phactr2Phosphatase and actin regulator. (582 aa)
neu3Treacher Collins-Franceschetti syndrome 1. (397 aa)
pld35'-3' exonuclease PLD3; 5'->3' DNA exonuclease which digests single-stranded DNA (ssDNA) (By similarity). Regulates inflammatory cytokine responses via the degradation of nucleic acids, by reducing the concentration of ssDNA able to stimulate TLR9, a nucleotide-sensing receptor in collaboration with PLD4 (By similarity). May be important in myotube formation. Plays a role in lysosomal homeostasis. Involved in the regulation of endosomal protein sorting (By similarity). (503 aa)
stx10t-SNARE coiled-coil homology domain-containing protein. (252 aa)
sec31aPregnancy-specific beta-1-glycoprotein 3. (1261 aa)
epn1UV-stimulated scaffold protein A. (652 aa)
slc45a2Uncharacterized protein. (586 aa)
LOC100496061Uncharacterized protein. (210 aa)
cd276Glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein. (88 aa)
SYT11C2 domain-containing protein. (124 aa)
slc45a1Nuclear receptor subfamily 0 group B member 1. (747 aa)
ENSXETP00000011813Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (180 aa)
syn2Oxysterol binding protein like 1A. (877 aa)
rab9bRAB9B, member RAS oncogene family. (201 aa)
DAB2DAB adaptor protein 2. (820 aa)
higd1a-2Solute carrier family 34 member 2. (1184 aa)
rab26Uncharacterized protein. (249 aa)
anxa3Annexin. (331 aa)
SEC31BSEC31 homolog B, COPII coat complex component. (1211 aa)
vps45Vacuolar protein sorting 45A; Belongs to the STXBP/unc-18/SEC1 family. (570 aa)
snx9Sorting nexin. (585 aa)
LOC100494227Pentaxin. (232 aa)
tubgcp2Pentaxin. (231 aa)
ABCA3ATP binding cassette subfamily A member 3. (1704 aa)
sv2aPlastin 1. (729 aa)
tcp11l2-2Uncharacterized protein. (987 aa)
zfyve28Lateral signaling target protein 2 homolog; Negative regulator of epidermal growth factor receptor (EGFR) signaling. Acts by promoting EGFR degradation in endosomes when not monoubiquitinated (By similarity); Belongs to the lst-2 family. (954 aa)
sec23bProtein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. (767 aa)
GABRA2Gamma-aminobutyric acid type A receptor alpha2 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (499 aa)
sv2cTrace amine-associated receptor 1. (725 aa)
EMILIN2Elastin microfibril interfacer 2. (1166 aa)
ap2a1AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (959 aa)
rab35RAB35, member RAS oncogene family. (201 aa)
clba1Family with sequence similarity 114 member A1. (296 aa)
znf609Zinc finger protein 609. (156 aa)
ocrlHairy and enhancer of split 5, gene 2. (909 aa)
epn2ENTH domain-containing protein. (586 aa)
syt1E2F transcription factor 4. (425 aa)
kcpPHD finger protein 6. (2331 aa)
ccdc136Uncharacterized protein. (416 aa)
pip4p2Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (276 aa)
copg2Coatomer subunit gamma-2; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity). (883 aa)
SLC35B4Solute carrier family 35 member B4. (331 aa)
slc45a4E3 ubiquitin-protein ligase ZNRF3. (784 aa)
INPP5BInositol polyphosphate-5-phosphatase B. (891 aa)
ZFAND1Zinc finger AN1-type containing 1. (268 aa)
tuba3eTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (462 aa)
tuba4Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (450 aa)
pef1Electron transfer flavoprotein dehydrogenase. (284 aa)
KCNV2Potassium voltage-gated channel modifier subfamily V member 2. (562 aa)
sec23aProtein transport protein Sec23A; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. Belongs to the SEC23/SEC24 family. SEC23 subfamily. (765 aa)
litafLipopolysaccharide-induced tumor necrosis factor-alpha factor homolog; Plays a role in endosomal protein trafficking and in targeting proteins for lysosomal degradation. May also contribute to the regulation of gene expression in the nucleus. Binds DNA (in vitro) and may play a synergistic role in the nucleus in regulating the expression of numerous cytokines. (188 aa)
npas3Uncharacterized protein. (949 aa)
CLEC16AC-type lectin domain containing 16A. (1043 aa)
DNAJC5BDnaJ heat shock protein family (Hsp40) member C5 beta. (196 aa)
scg3Secretogranin-3; Member of the granin protein family that regulates the biogenesis of secretory granules (By similarity). Acts as a sorting receptor for intragranular proteins including chromogranin A/CHGA (By similarity). May also play a role in angiogenesis. Promotes endothelial proliferation, migration and tube formation through MEK/ERK signaling pathway (By similarity). (461 aa)
atp6v0bUncharacterized protein; Belongs to the V-ATPase proteolipid subunit family. (216 aa)
abcb6ATP-binding cassette sub-family B member 6, mitochondrial; Binds heme and porphyrins and functions in their ATP- dependent uptake into the mitochondria. Plays a crucial role in heme synthesis (By similarity). (852 aa)
RAB3CRAB3C, member RAS oncogene family. (227 aa)
sv2bDesmoplakin. (711 aa)
mregMelanoregulin; Probably functions as cargo-recognition protein that couples cytoplasmic vesicles to the transport machinery. Contributes to retrograde melanosome transport from the cell periphery to the center. Overexpression causes accumulation of late endosomes and/or lysosomes at the microtubule organising center (MTOC) at the center of the cell. Probably binds cholesterol and requires the presence of cholesterol in membranes to function in microtubule-mediated retrograde organelle transport. Binds phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, phosphatidylinosi [...] (270 aa)
ap4m1AP-4 complex subunit mu-1; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin- associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asym [...] (446 aa)
COPZ2Coatomer subunit zeta; The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex. (180 aa)
prr15lUncharacterized protein. (96 aa)
rab5aRAB5A, member RAS oncogene family. (216 aa)
trarg1Trafficking regulator of GLUT4 1; Regulates insulin-mediated adipose tissue glucose uptake and transport by modulation of SLC2A4 recycling. Belongs to the CD225/Dispanin family. (179 aa)
SLC17A8Solute carrier family 17 member 8. (588 aa)
gad2Peptidoglycan recognition protein 1. (588 aa)
LOC101732697G protein-coupled receptor 158. (209 aa)
coro6Coronin; Belongs to the WD repeat coronin family. (471 aa)
tmtc2-2Transmembrane and tetratricopeptide repeat containing 2. (878 aa)
tyrp1Tyrosinase-related protein 1. (534 aa)
rab32Uncharacterized protein. (258 aa)
miga1Uncharacterized protein. (574 aa)
prrt1Sushi domain containing 2. (240 aa)
lamtor3-likeRagulator complex protein LAMTOR3; Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids. Adapter protein that may regulate the MAP kinase cascade (By similarity). (124 aa)
chmp4bCharged multivesicular body protein 4b; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids (By similarity). (222 aa)
ENSXETP00000047030Uncharacterized protein. (337 aa)
wdr91WD repeat-containing protein 91; Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport; Belongs to the WD repeat WDR91 family. (751 aa)
scarb2Uncharacterized protein; Belongs to the CD36 family. (487 aa)
psap-2Prosaposin (variant Gaucher disease and variant metachromatic leukodystrophy). (257 aa)
tgm2-2Transglutaminase 2. (2204 aa)
namptNicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. (506 aa)
copaCoatomer subunit alpha; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. (1240 aa)
LOC100492396Ribonuclease H2 subunit B. (240 aa)
chmp5Charged multivesicular body protein 5; Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids (By similarity). (240 aa)
coro1cCoronin; Belongs to the WD repeat coronin family. (751 aa)
gpr143G_PROTEIN_RECEP_F2_4 domain-containing protein. (414 aa)
syn3Uncharacterized protein. (570 aa)
pamUncharacterized protein. (985 aa)
RASSF9Ras association domain family member 9. (422 aa)
smc2-2Structural maintenance of chromosomes 2. (1957 aa)
rab3dRAB3D, member RAS oncogene family. (216 aa)
lamtor2Ragulator complex protein LAMTOR2; Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids. Adapter protein that may regulate the MAP kinase cascade (By similarity). (125 aa)
ap2a2AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (1010 aa)
sulf2Extracellular sulfatase. (875 aa)
tmem184bNaked cuticle homolog 1. (425 aa)
stx6Regulator of G-protein signaling 10; Belongs to the syntaxin family. (264 aa)
vma21Vacuolar ATPase assembly integral membrane protein vma21; Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum; Belongs to the VMA21 family. (104 aa)
SYTL4Synaptotagmin like 4. (692 aa)
LOC100036702Exonuclease domain-containing protein. (1053 aa)
bri3LOC100144285 protein. (134 aa)
chmp7Charged multivesicular body protein 7; ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope during late anaphase. Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase. Plays a role in the endosomal sorting pathway; Belongs to the SNF7 family. (469 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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