STRINGSTRING
KNTC1 KNTC1 agbl2 agbl2 fuz fuz dzip1l dzip1l poldip2 poldip2 pifo pifo cep78 cep78 rabl2b rabl2b OFD1 OFD1 cfap157 cfap157 FAM92B FAM92B ift122 ift122 wdr44 wdr44 entr1 entr1 FANK1 FANK1 cep41 cep41 mkks mkks arhgap35 arhgap35 ndrg4 ndrg4 ift57 ift57 cep19 cep19 AHI1 AHI1 cfap206 cfap206 rab28 rab28 TAPT1 TAPT1 CDC14A CDC14A armc9 armc9 dync2li1 dync2li1 b9d1 b9d1 WDR11 WDR11 tbc1d30 tbc1d30 cplane2 cplane2 ssna1 ssna1 atg4d-2 atg4d-2 LOC100497171 LOC100497171 ttll11 ttll11 RPGRIP1L RPGRIP1L bbof1 bbof1 cby1 cby1 LOC100498570 LOC100498570
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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KNTC1Kinetochore associated 1. (2236 aa)
agbl2Cytosolic carboxypeptidase 2; Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Does not show detyrosinase or deglycylase activities from the carboxy-terminus of tubulin. (968 aa)
fuzProtein fuzzy homolog; Probable planar cell polarity effector involved in cilium biogenesis. Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies. May regulate protein and membrane transport to the cilium. May control the organization of the apical actin cytoskeleton, which is essential for the normal orientation of elongating ciliary microtubules. (418 aa)
dzip1lC2H2-type domain-containing protein. (776 aa)
poldip2Serine hydrolase-like (pseudogene). (403 aa)
pifoUncharacterized protein. (192 aa)
cep78Centrosomal protein of 78 kDa; May be required for efficient PLK4 centrosomal localization and PLK4-induced overduplication of centrioles. May play a role in cilium biogenesis; Belongs to the CEP78 family. (727 aa)
rabl2bRAB, member of RAS oncogene family-like 2A. (225 aa)
OFD1OFD1 centriole and centriolar satellite protein. (749 aa)
cfap157Cilia- and flagella-associated protein 157; Specifically required during spermatogenesis for flagellum morphogenesis and sperm motility; Belongs to the CFAP157 family. (520 aa)
FAM92BFamily with sequence similarity 92 member B. (268 aa)
ift122Intraflagellar transport protein 122 homolog; Required for cilia formation during embryonal development. Acts as a negative regulator of Shh signaling. (1222 aa)
wdr44Uncharacterized protein. (912 aa)
entr1Endosome-associated-trafficking regulator 1; Endosome-associated protein that plays a role in membrane receptor sorting, cytokinesis and ciliogenesis. Belongs to the ENTR1 family. (346 aa)
FANK1Fibronectin type III and ankyrin repeat domains 1. (338 aa)
cep41Centrosomal protein of 41 kDa; Required during ciliogenesis for tubulin glutamylation in cilium. Probably acts by participating in the transport of tubulin polyglutamylases between the basal body and the cilium (By similarity). Belongs to the CEP41 family. (370 aa)
mkksNeuronal calcium sensor 1. (611 aa)
arhgap35Bora, aurora kinase A activator. (1472 aa)
ndrg4Protein NDRG4; Contributes to the maintenance of intracerebral BDNF levels within the normal range. May enhance growth factor-induced ERK1 and ERK2 phosphorylation. May attenuate growth factor-promoted ELK1 phosphorylation in a microtubule-dependent manner (By similarity). Belongs to the NDRG family. (407 aa)
ift57Intraflagellar transport protein 57 homolog; Required for the formation of cilia. May also have pro- apoptotic function (By similarity); Belongs to the IFT57 family. (411 aa)
cep19Centrosomal protein of 19 kDa; Required for ciliation. Recruits the RABL2B GTPase to the ciliary base to initiate ciliation; Belongs to the CEP19 family. (163 aa)
AHI1Abelson helper integration site 1. (747 aa)
cfap206Transmembrane protein 127. (657 aa)
rab28RAB28, member RAS oncogene family. (221 aa)
TAPT1Transmembrane anterior posterior transformation 1. (549 aa)
CDC14ACell division cycle 14A. (575 aa)
armc9LisH domain-containing protein ARMC9; Acts as a positive regulator of hedgehog (Hh) signaling (By similarity). Involved in ciliogenesis (By similarity). (817 aa)
dync2li1Uncharacterized protein. (341 aa)
b9d1B9 domain-containing protein 1; Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity). (203 aa)
WDR11WD repeat domain 11. (1099 aa)
tbc1d30TBC1 domain family member 30. (937 aa)
cplane2Ciliogenesis and planar polarity effector 2; Potential effector of the planar cell polarity signaling pathway. Plays a role in targeted membrane trafficking most probably at the level of vesicle fusion with membranes. Involved in cilium biogenesis by regulating the transport of cargo proteins to the basal body and to the apical tips of cilia. More generally involved in exocytosis in secretory cells (By similarity). Belongs to the small GTPase superfamily. Rab family. (227 aa)
ssna1Uncharacterized protein. (116 aa)
atg4d-2Autophagy related 4D, cysteine peptidase. (561 aa)
LOC100497171Lebercilin domain-containing protein. (590 aa)
ttll11RAB24, member RAS oncogene family. (739 aa)
RPGRIP1LRPGRIP1 like. (1266 aa)
bbof1MLLT11, transcription factor 7 cofactor. (531 aa)
cby1Immunoglobulin superfamily member 5. (164 aa)
LOC100498570Uncharacterized protein. (312 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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