STRINGSTRING
cbx5 cbx5 nbn nbn lrwd1 lrwd1 terf1 terf1 dmrt2 dmrt2 knl1 knl1 bub1b bub1b wdsub1 wdsub1 meaf6 meaf6 pot1 pot1 cbx1 cbx1 sgo1 sgo1 LOC101734831 LOC101734831 ctnna1 ctnna1 TMEM245 TMEM245 zfp36l2.1 zfp36l2.1 mki67 mki67 spc25 spc25 aurkb aurkb CENPK CENPK ctc1 ctc1 ZNF827 ZNF827 cenpl cenpl gpatch11 gpatch11 rsph10b rsph10b anapc16 anapc16 rapgef6 rapgef6 dclre1b dclre1b loc100145174 loc100145174 Rskr Rskr spag5 spag5 wrn wrn tnks tnks LOC100144966 LOC100144966 cenpn cenpn LOC100145507 LOC100145507 LOC101732421 LOC101732421 RCC2 RCC2 nuf2 nuf2 Terb1 Terb1 zfp36l2.2 zfp36l2.2 CENPW CENPW kif2c kif2c cdca9 cdca9 rimbp2 rimbp2 ttk ttk CENPF CENPF cenpi cenpi CDT1 CDT1 DHX36 DHX36 LOC100486918 LOC100486918 bub1 bub1 spc24 spc24 LOC100491826 LOC100491826 arntl arntl BOD1L1 BOD1L1 rnf8 rnf8 birc5l birc5l hells hells cenpt cenpt ska2 ska2 pmf1 pmf1 zw10 zw10 ska3 ska3 recql4 recql4 pinx1 pinx1 eif2s3 eif2s3 plk1 plk1 tert tert slc17a6 slc17a6 tinf2 tinf2 LOC100496812 LOC100496812 cenpc cenpc terb2 terb2 macroh2a1 macroh2a1 terf2 terf2 ABLIM2 ABLIM2 ZNF618 ZNF618 tgif1 tgif1 kmt5b kmt5b lingo2 lingo2 sirt6 sirt6 cdca5 cdca5 fbxo28 fbxo28 ikzf1 ikzf1 zbtb48 zbtb48 fam43b fam43b terf2ip terf2ip fam43a fam43a dsn1 dsn1 tm7sf3 tm7sf3 cenph cenph SMC5 SMC5 ska1 ska1 CKAP5 CKAP5 spdl1 spdl1 NSMCE4A NSMCE4A nsl1 nsl1 cenpo cenpo zwilch zwilch kdm1a kdm1a nek2 nek2 kmt5c kmt5c ncapd3 ncapd3 cenpv cenpv stn1 stn1 mtbp mtbp ten1 ten1 mis12 mis12 bod1 bod1 ndc80 ndc80 LOC100491922 LOC100491922 FLNA FLNA RIF1 RIF1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
cbx5TNF alpha induced protein 6. (200 aa)
nbnNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (806 aa)
lrwd1Leucine-rich repeat and WD repeat-containing protein 1; Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post- replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability (By similarity); Belongs to the LRWD1 family. (691 aa)
terf1Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (448 aa)
dmrt2Lysine (K)-specific demethylase 2B. (528 aa)
knl1Uncharacterized loc496670. (2794 aa)
bub1bUncharacterized protein. (1022 aa)
wdsub1Dynein axonemal heavy chain 14. (485 aa)
meaf6Chromatin modification-related protein MEAF6; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vi [...] (250 aa)
pot1Telo_bind domain-containing protein. (629 aa)
cbx1Chromobox homolog 1 (HP1 beta homolog Drosophila ). (184 aa)
sgo1Calcium transporter 2. (660 aa)
LOC101734831Metallophosphoesterase domain containing 2. (191 aa)
ctnna1V-set domain-containing T cell activation inhibitor 1. (931 aa)
TMEM245Transmembrane protein 245. (960 aa)
zfp36l2.1Replication factor C subunit 2. (281 aa)
mki67F-box protein 38. (2078 aa)
spc25Kinetochore protein Spc25; Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules. (228 aa)
aurkbAurora kinase B; Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Key component of [...] (375 aa)
CENPKCentromere protein K. (291 aa)
ctc1Mitogen-activated protein kinase 1. (1047 aa)
ZNF827Zinc finger protein 827. (1290 aa)
cenplCentromere protein L; Probable component of a centromeric complex involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation; Belongs to the CENP-L/IML3 family. (348 aa)
gpatch11G patch domain-containing protein 11. (266 aa)
rsph10bUncharacterized protein. (537 aa)
anapc16Anaphase-promoting complex subunit 16; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity); Belongs to the APC16 family. (144 aa)
rapgef6Uncharacterized protein. (1644 aa)
dclre1bHeat shock protein family A (Hsp70) member 5. (517 aa)
loc100145174Uncharacterized LOC100145174. (932 aa)
RskrProtein kinase domain-containing protein. (180 aa)
spag5Interferon induced, with helicase C domain 1. (1498 aa)
wrnCell death-inducing p53-target protein 1. (1432 aa)
tnksPoly [ADP-ribose] polymerase. (1306 aa)
LOC100144966Short stature homeobox 2; Belongs to the protein kinase superfamily. (398 aa)
cenpnCentromere protein N; Probable component of a centromeric complex involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation; Belongs to the CENP-N/CHL4 family. (366 aa)
LOC100145507LOC100145507 protein. (684 aa)
LOC101732421Baculoviral IAP repeat-containing protein 5.1; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Stimulates the mitotic kinase activity of aurkb/aurora-B in the CPC. Does not appear to exhibit anti-apoptotic activity (By similarity). (139 aa)
RCC2Regulator of chromosome condensation 2. (447 aa)
nuf2Msh homeobox 1. (462 aa)
Terb1Uncharacterized protein. (329 aa)
zfp36l2.2Uncharacterized protein. (289 aa)
CENPWCentromere protein W. (108 aa)
kif2cKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (715 aa)
cdca9Borealin-2; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Contributes to CPC function by facilitating loading of the CPC onto chromosomes (By similarity). (296 aa)
rimbp2Zinc finger protein 384. (1470 aa)
ttkProtein kinase domain-containing protein. (879 aa)
CENPFCentromere protein F. (2609 aa)
cenpiUncharacterized protein. (718 aa)
CDT1Chromatin licensing and DNA replication factor 1. (617 aa)
DHX36DEAH-box helicase 36. (1006 aa)
LOC100486918Sperm associated antigen 6. (621 aa)
bub1BUB1 budding uninhibited by benzimidazoles 1 homolog. (1122 aa)
spc24Kinetochore protein spc24; Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules. (205 aa)
LOC100491826CENP-H domain-containing protein. (256 aa)
arntlSin3A associated protein 18kDa. (513 aa)
BOD1L1Uncharacterized protein. (3149 aa)
rnf8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (535 aa)
birc5lBaculoviral IAP repeat-containing protein 5.2; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Does not appear to exhibit anti-apoptotic activity. Plays a role in increasing blood vessel size during development (By similarity). (157 aa)
hellsUncharacterized protein. (840 aa)
cenptProstaglandin D2 synthase. (777 aa)
ska2Phosphoinositide-3-kinase interacting protein 1. (163 aa)
pmf1LOC100037873 protein. (202 aa)
zw10Uncharacterized protein. (780 aa)
ska3Spindle and kinetochore-associated protein 3; Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it mediates the microtubule-stimulated oligomerization. Affinity for microtubules is synergistically enhanced in the p [...] (564 aa)
recql4Integrator complex subunit 10. (1463 aa)
pinx1Leucine rich repeat containing 14. (337 aa)
eif2s3Eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa. (472 aa)
plk1Serine/threonine-protein kinase PLK1; Plays multiple essential roles during mitosis. Phosphorylates the N-terminal domain of cdc25, which leads to cyclin b-cdc2 activation and mitotic entry. Also required for organization of bipolar spindles, and for exit from mitosis. Phosphorylates tpx2 (By similarity). (598 aa)
tertTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (1196 aa)
slc17a6LDL receptor related protein associated protein 1. (583 aa)
tinf2TRF1 interacting nuclear factor 2. (362 aa)
LOC100496812Uncharacterized protein. (1315 aa)
cenpcCENP-C_C domain-containing protein. (1378 aa)
terb2Uncharacterized protein. (199 aa)
macroh2a1Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
terf2Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (471 aa)
ABLIM2Actin binding LIM protein family member 2. (560 aa)
ZNF618Zinc finger protein 618. (917 aa)
tgif1Myogenic differentiation 1. (278 aa)
kmt5bClathrin interactor 1. (844 aa)
lingo2Leucine rich repeat and Ig domain containing 2. (255 aa)
sirt6Sirtuin (Silent mating type information regulation 2 homolog) 6. (331 aa)
cdca5LOC100145078 protein. (274 aa)
fbxo28F-box domain-containing protein. (320 aa)
ikzf1SIX homeobox 3. (536 aa)
zbtb48Microtubule affinity regulating kinase 2. (736 aa)
fam43bProtein C, inactivator of coagulation factors Va and VIIIa. (317 aa)
terf2ipTelomeric repeat-binding factor 2-interacting protein 1; Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). Does not bind DNA directly: recruited to telomeric double-stranded 5'- TTAGGG-3' repeats via its interaction with terf2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with terf2 or other factors, and regulates gene expression (By similarity). (552 aa)
fam43aLOC100135352 protein. (353 aa)
dsn1Uncharacterized protein. (340 aa)
tm7sf3Histone-binding protein RBBP4. (505 aa)
cenphMicrotubule associated serine/threonine kinase 3. (246 aa)
SMC5Structural maintenance of chromosomes 5. (1069 aa)
ska1Spindle and kinetochore-associated protein 1; Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a [...] (256 aa)
CKAP5Cytoskeleton associated protein 5. (2003 aa)
spdl1Protein Spindly; Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. May act as an adapter protein linking the dynein motor complex to various cargos (By similarity); Belongs to the Spindly family. (611 aa)
NSMCE4ANon-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. (362 aa)
nsl1Uncharacterized protein. (880 aa)
cenpoCentromere protein O; Probable component of a centromeric complex involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation; Belongs to the CENP-O/MCM21 family. (330 aa)
zwilchProtein zwilch homolog; Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and mad1-mad2 complexes onto kinetochores (By similarity). (597 aa)
kdm1aLysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (841 aa)
nek2Matrix metallopeptidase 9. (444 aa)
kmt5cLOC100145748 protein. (772 aa)
ncapd3Pre-mRNA-splicing factor 38A. (1492 aa)
cenpvCyclin and CBS domain divalent metal cation transport mediator 2. (232 aa)
stn1CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (368 aa)
mtbpMdm2-binding protein; May play a role in mdm2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of mdm2, thereby enhancing mdm2 stability. This promotes mdm2-mediated ubiquitination of p53/TP53 and its subsequent degradation (By similarity). (867 aa)
ten1Uncharacterized protein. (124 aa)
mis12Uncharacterized protein. (221 aa)
bod1Biorientation of chromosomes in cell division protein 1; Required for proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles. Belongs to the BOD1 family. (169 aa)
ndc80Kinetochore protein NDC80 homolog; Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules. May play a role in chromosome congression and may be essential for the end-on attachment of the kinetochores t [...] (640 aa)
LOC100491922UDP-glucose glycoprotein glucosyltransferase 2. (1171 aa)
FLNAFilamin A. (2578 aa)
RIF1Replication timing regulatory factor 1. (2264 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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