STRINGSTRING
sox21 sox21 dvl3 dvl3 parg parg klf5 klf5 pdlim4 pdlim4 pard6g pard6g mpp2-2 mpp2-2 ptpn13 ptpn13 topbp1 topbp1 htra1 htra1 adgrd1 adgrd1 mast1-2 mast1-2 lnx2 lnx2 LOC101730309 LOC101730309 uqcr11 uqcr11 dlg1 dlg1 LOC100486784 LOC100486784 gipc1 gipc1 ldlrad4 ldlrad4 chrna6 chrna6 thra thra pcdh8.2 pcdh8.2 LOC101733556 LOC101733556 osr2 osr2 dvl2 dvl2 pdzd2-2 pdzd2-2 intu intu marchf6 marchf6 arhgef12-2 arhgef12-2 synj2bp synj2bp cln8 cln8 mpp1 mpp1 slc9a3r1 slc9a3r1 mpp7 mpp7 shroom2 shroom2 magi3 magi3 arhgap21 arhgap21 pip4k2b pip4k2b
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
sox21Glutathione reductase. (271 aa)
dvl3Segment polarity protein dishevelled homolog DVL-3; Involved in the signal transduction pathway mediated by multiple Wnt genes (By similarity). Required during ciliogenesis for the docking of basal bodies to the apical plasma membrane (By similarity); Belongs to the DSH family. (713 aa)
pargUncharacterized protein. (1107 aa)
klf5Kruppel-like factor 5 (intestinal). (134 aa)
pdlim4Phosphoserine aminotransferase 1. (332 aa)
pard6gPar-6 partitioning defective 6 homolog gamma (C. elegans). (384 aa)
mpp2-2ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H. (328 aa)
ptpn13Ras protein specific guanine nucleotide releasing factor 1. (2513 aa)
topbp1Protein phosphatase 1 regulatory inhibitor subunit 14B. (1515 aa)
htra1Serine protease HTRA1; Serine protease with a variety of targets, including extracellular matrix proteins and proteoglycans such as biglycan, syndecan-4 and glypican-4. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Consequently, facilitates inductive processes in the developping embryo, such as posteriorization, mesoderm induction and neuronal differentiation. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits [...] (458 aa)
adgrd1TBC1 domain family member 9B; Belongs to the G-protein coupled receptor 2 family. (983 aa)
mast1-2C2 domain-containing protein. (60 aa)
lnx2PDZ domain containing ring finger 1. (685 aa)
LOC101730309Reticulophagy regulator 3. (228 aa)
uqcr11Uncharacterized protein. (56 aa)
dlg1Disks large homolog 1; Essential multidomain scaffolding protein required for normal development. Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. May play a role in adherens junction assembly, signal transduction and cell proliferation (By similarity). (927 aa)
LOC100486784Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (227 aa)
gipc1GIPC PDZ domain containing family, member 1. (332 aa)
ldlrad4Hepatocyte nuclear factor 4 alpha. (310 aa)
chrna6Non-SMC condensin I complex subunit H. (466 aa)
thraApolipoprotein A4. (407 aa)
pcdh8.2Protocadherin 8, gene 2. (108 aa)
LOC101733556Sorcin. (303 aa)
osr2Podocan. (312 aa)
dvl2Segment polarity protein dishevelled homolog DVL-2; Involved in at least 2 independent signaling cascades, controlling cell fate via canonical Wnt signaling and cell polarity via a planar cell polarity (PCP) cascade. Acts synergistically with dal/dapple-like to activate Wnt signaling, stabilizing ctnnb1/beta- catenin and leading to dorsal axis formation. Also prevents degradation of ctnnb1/beta-catenin by displacing gsk3 from a complex with ARP/Axin- related protein. Has an additional role in anterior-posterior (A/P) axis formation, specifying different neuroectodermal cell fates along [...] (316 aa)
pdzd2-2IKAROS family zinc finger 1. (162 aa)
intuProtein inturned; Plays a role in the definition of cell polarity via the planar cell polarity (PCP) cascade. Required for ciliogenesis by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Proposed to function as core component of a functional module called CPLANE (ciliogenesis and planar polarity effectors) involved in recruitment of peripheral IFT-A proteins to basal bodies. Controls the localization of both rhoa and [...] (953 aa)
marchf6WNT inhibitory factor 1. (918 aa)
arhgef12-2Uncharacterized protein. (816 aa)
synj2bpSynj2bp protein. (145 aa)
cln8Actin related protein 2/3 complex subunit 3. (298 aa)
mpp1Extracellular matrix protein 2, female organ and adipocyte-specific, gene 1; Belongs to the MAGUK family. (460 aa)
slc9a3r1Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (320 aa)
mpp7MAGUK p55 subfamily member 7; Acts as an important adapter that promotes epithelial cell polarity and tight junction formation. Involved in the assembly of protein complexes at sites of cell-cell contact (By similarity). Belongs to the MAGUK family. (576 aa)
shroom2Protein Shroom2; May be involved in endothelial cell morphology changes during cell spreading. Required for eye pigmentation. In the retinal pigment epithelium, regulates the biogenesis of melanosomes and promotes their association with the apical cell surface by inducing gamma-tubulin redistribution. (1686 aa)
magi3Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3; Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes; Belongs to the MAGUK family. (1595 aa)
arhgap21Rho GTPase-activating protein 21; GTPase-activating protein (GAP) for rhoa and cdc42. (1933 aa)
pip4k2bLaeverin. (426 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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