STRINGSTRING
fhl3 fhl3 MICAL2 MICAL2 fhl1 fhl1 lmo4.1 lmo4.1 lhx5 lhx5 lmo4.2 lmo4.2 lhx1 lhx1 pdlim4 pdlim4 csrp3 csrp3 ccdc13 ccdc13 adgrd1 adgrd1 lhx8 lhx8 prickle1-2 prickle1-2 lmo2 lmo2 chrna6 chrna6 sgo2 sgo2 prickle1 prickle1 limd1 limd1 rnf222 rnf222 rtkn2 rtkn2 prickle4 prickle4 RIBC2 RIBC2 tes tes lasp1 lasp1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
fhl3Four and a half LIM domains 3. (279 aa)
MICAL2[F-actin]-monooxygenase mical2; Nuclear monooxygenase that promotes depolymerization of F- actin by mediating oxidation of specific methionine residues on actin and regulates the srf signaling. Acts by modifying nuclear actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization (By similarity). Acts as a key regulator of the srf signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase mkl1/mrtf-a presence i [...] (1040 aa)
fhl1Four and a half LIM domains 1. (296 aa)
lmo4.1LIM domain transcription factor LMO4.2; Acts as a positive cofactor of GATA transcription factors to establish the identity of the ventral mesoderm during gastrulation. Down-regulation in the dorsal mesoderm is necessary for the proper formation of this territory since, when present, lmo4 may bind ldb1 and restrict the availability of this cofactor for Spemman organizer transcription factors. At neurula stages, suppresses primary neuron differentiation and modulates gene expression at the Isthmic Organizer of the midbrain-hindbrain boundary (By similarity). (184 aa)
lhx5Kruppel-like factor 2. (402 aa)
lmo4.2LIM domain transcription factor LMO4.1; Acts as a positive cofactor of GATA transcription factors to establish the identity of the ventral mesoderm during gastrulation. Down-regulation in the dorsal mesoderm is necessary for the proper formation of this territory since, when present, lmo4 may bind ldb1 and restrict the availability of this cofactor for Spemman organizer transcription factors. At neurula stages, suppresses primary neuron differentiation and modulates gene expression at the Isthmic Organizer of the midbrain-hindbrain boundary (By similarity). (237 aa)
lhx1G elongation factor, mitochondrial 2. (409 aa)
pdlim4Phosphoserine aminotransferase 1. (332 aa)
csrp3Cysteine and glycine-rich protein 2. (194 aa)
ccdc13Monooxygenase, DBH-like 1. (704 aa)
adgrd1TBC1 domain family member 9B; Belongs to the G-protein coupled receptor 2 family. (983 aa)
lhx8LIM homeobox 7/8. (374 aa)
prickle1-2Peroxisomal trans-2-enoyl-CoA reductase. (136 aa)
lmo2Rhombotin-2; Transcription factor that acts synergistically with tal1/scl and gata1 to specify embryonic dorsal mesoderm to a hematopoietic fate. Induces globin gene expression together with fgf (By similarity). (158 aa)
chrna6Non-SMC condensin I complex subunit H. (466 aa)
sgo2Uncharacterized protein. (890 aa)
prickle1Prickle-like protein 1; Acts in a planar cell polarity (PCP) complex; polarization along the apical/basal axis of epithelial cells. Regulates the polarized assembly of fibronectrin on the surface of the mesoderm during gastrulation. Essential for gastrulation cell movements, cooperating with dvl2/dsh to activate jnk. Acts together with tes to control axial elongation (By similarity). (871 aa)
limd1LIM domain-containing protein 1; Acts as a transcriptional corepressor for snai1 and snai2/slug and plays a role in regulating neural crest development. (589 aa)
rnf222RING-type domain-containing protein. (247 aa)
rtkn2PH domain-containing protein. (610 aa)
prickle4Holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase). (438 aa)
RIBC2RIB43A domain with coiled-coils 2. (379 aa)
tesTestin; Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. May inhibit cell growth (By similarity). Regulates cranial neural crest migration. Acts together with prickle1 to control axial elongation (By similarity). (422 aa)
lasp1LIM and SH3 protein 1. (258 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.