STRINGSTRING
ssb ssb sf3b6 sf3b6 cirbp cirbp setd1a-2 setd1a-2 snrpa snrpa ncoa4 ncoa4 elavl1 elavl1 celf5 celf5 nmt2 nmt2 elavl4 elavl4 MGC147226 MGC147226 prokr2 prokr2 rbm4b rbm4b rnpc3 rnpc3 ralyl ralyl DOCK8 DOCK8 rbm17 rbm17 marf1 marf1 nifk-2 nifk-2 alyref alyref gin1 gin1 slc6a7 slc6a7 hipk2 hipk2 rbm5 rbm5 elavl2 elavl2 setd1b setd1b C1QBP C1QBP rnps1 rnps1 tardbp tardbp cpeb3 cpeb3 eif4h eif4h rbfox2 rbfox2 srsf9 srsf9 mrps9 mrps9 tra2a-2 tra2a-2 rcan2 rcan2 rbm38 rbm38 rbm46 rbm46 elavl2-3 elavl2-3 JMJD8 JMJD8 jpt2 jpt2 uqcrc1 uqcrc1 MARCHF11 MARCHF11 nifk nifk srsf2 srsf2 F6UTD6_XENTR F6UTD6_XENTR rbm22 rbm22 arhgef39 arhgef39 celf4 celf4 sltm-2 sltm-2 srsf3 srsf3 ddx21 ddx21 hnrnpll hnrnpll ewsr1 ewsr1 rbm42 rbm42 SPTBN5 SPTBN5 puf60-2 puf60-2 puf60-3 puf60-3 hnrnpd-2 hnrnpd-2 tut1 tut1 cpeb4 cpeb4 rcan3 rcan3 hnrnpdl hnrnpdl esrp1 esrp1 snrnp70 snrnp70 pabpn1l pabpn1l snx12 snx12 rbm12b.1 rbm12b.1 isyna1 isyna1 nono nono celf1 celf1 srsf12 srsf12 larp7 larp7 pabpc1l pabpc1l raver1 raver1 pabpn1 pabpn1 cd82 cd82 foxn1 foxn1 eif3g eif3g larp6-like.1 larp6-like.1 rbm26-2 rbm26-2 ncbp2 ncbp2 tp73 tp73 srsf1 srsf1 srsf5 srsf5 elavl3 elavl3 alkbh8 alkbh8 mmaa mmaa celf2 celf2 rev1 rev1 bok bok nol8 nol8 ptbp2 ptbp2 hnrnpa1-3 hnrnpa1-3 nup35 nup35 srek1-2 srek1-2 dnajc17-2 dnajc17-2 acin1 acin1 PKD2L1 PKD2L1 rbm24 rbm24 ppil4 ppil4 sp6 sp6 hnrnpa3 hnrnpa3 dazl dazl
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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ssbSjogren syndrome antigen B (Autoantigen La). (426 aa)
sf3b6Splicing factor 3B, 14 kDa subunit (Sf3b14). (125 aa)
cirbpCold-inducible RNA-binding protein; Cold-inducible mRNA binding protein. Acts cooperatively with elavl1/elrA to stabilize AU-rich element (ARE)-containing mRNAs by binding to themm and inhibiting their deadenylation. Essential for embryonic gastrulation and neural development, acting to maintain the expression of a set of adhesion molecules, and cell movement during embryogenesis. Required for pronephros development (By similarity). (198 aa)
setd1a-2Gamma-glutamyltransferase 5. (138 aa)
snrpaSmall nuclear ribonucleoprotein polypeptide A. (282 aa)
ncoa4Mitochondrial ribosomal protein L41. (634 aa)
elavl1ELAV-like protein 1; RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability. Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation (By similarity). Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs. Acts cooperatively with cribp to stabilize AU-rich sequence (ARE)-containing mRNAs. May play a role during gastrulation. Required for the vegetal localization of vg1 mRNA (By similarity). (336 aa)
celf5CUGBP Elav-like family member 5; RNA-binding protein that may be implicated in the regulation of pre-mRNA alternative splicing; Belongs to the CELF/BRUNOL family. (499 aa)
nmt2Glycylpeptide N-tetradecanoyltransferase; Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins; Belongs to the NMT family. (484 aa)
elavl4ELAV-like protein 4; RNA-binding protein that is involved in the post- transcriptional regulation of mRNAs (By similarity). Plays a role in the regulation of mRNA stability, alternative splicing and translation (By similarity). Binds to AU-rich element (ARE) sequences in the 3' untranslated region (3'UTR) of target mRNAs (By similarity). Mainly plays a role in neuron-specific RNA processing (By similarity). Belongs to the RRM elav family. (430 aa)
MGC147226Saccharopine dehydrogenase (putative). (521 aa)
prokr2Dual oxidase 1; Belongs to the G-protein coupled receptor 1 family. (378 aa)
rbm4bNF-kappa-B inhibitor zeta-like. (338 aa)
rnpc3RNA-binding region (RNP1, RRM) containing 3. (527 aa)
ralylRNA-binding Raly-like protein; Belongs to the RRM HNRPC family. RALY subfamily. (333 aa)
DOCK8Dedicator of cytokinesis 8; Belongs to the DOCK family. (2040 aa)
rbm17RNA binding motif protein 17. (399 aa)
marf1Meiosis regulator and mRNA stability factor 1; Essential regulator of oogenesis required for female meiotic progression to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. (1682 aa)
nifk-2MICAL like 1. (99 aa)
alyrefTHO complex subunit 4; Export adapter involved in nuclear export of spliced and unspliced mRNA. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NFX1 pathway). Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap- dependent manner to a regio [...] (260 aa)
gin1Brevican. (416 aa)
slc6a7Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (645 aa)
hipk2Protein kinase domain-containing protein. (753 aa)
rbm5RNA-binding protein 5; Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron (By similarity). (838 aa)
elavl2ELAV-like protein 2; Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs. Required for the vegetal localization of vg1 mRNA. Probably required for nervous system development (By similarity). Belongs to the RRM elav family. (390 aa)
setd1bHistone-lysine N-methyltransferase SETD1B; Histone methyltransferase that specifically methylates 'Lys- 4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. (1962 aa)
C1QBPComplement C1q binding protein. (272 aa)
rnps1RNA-binding protein with serine-rich domain 1; Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Putative component of the spliceosome which enhances the formation of the ATP-dependent A complex of the spliceosome. May participate in mRNA 3'-end cleavage. Also mediates increase of mRNA a [...] (344 aa)
tardbpTAR DNA-binding protein 43; Probably involved in transcriptional repression (By similarity). May play a role in the maintenance of the circadian clock periodicity. (418 aa)
cpeb3Cytoplasmic polyadenylation element-binding protein 3; Sequence-specific RNA-binding protein which acts as a translational repressor in the basal unstimulated state but, following neuronal stimulation, acts as a translational activator (By similarity). Does not bind to the cytoplasmic polyadenylation element (CPE), a uridine-rich sequence element within the mRNA 3'-UTR, but binds to a U-rich loop within a stem-loop structure (By similarity). Required for the consolidation and maintenance of hippocampal-based long term memory (By similarity). Inhibits differentiation of intermediate mes [...] (603 aa)
eif4hWilliams-Beuren syndrome chromosome region 1 homolog. (252 aa)
rbfox2RNA binding protein fox-1 homolog 2; RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Regulates alternative splicing of tissue-specific exons (By similarity). (444 aa)
srsf9Splicing factor, arginine/serine-rich 9. (225 aa)
mrps9Zinc finger E-box binding homeobox 2; Belongs to the universal ribosomal protein uS9 family. (384 aa)
tra2a-2Cysteine-rich protein 3. (173 aa)
rcan2Down syndrome critical region gene 1-like 1. (243 aa)
rbm38RNA-binding protein 38; RNA-binding protein that specifically bind the 3'-UTR of VegT transcripts, leading to maintain their stability and stimulate their translation, thereby playing a role in germ layer formation. VegT is a localized maternal determinant essentially required for endoderm formation. Also has some proneural function in the open neural plate and in the context of retinogenesis. May also act as a mRNA splicing factor. May play a role in myogenic differentiation (By similarity). Belongs to the RBM38 family. (219 aa)
rbm46Probable RNA-binding protein 46. (534 aa)
elavl2-3Olfactory receptor. (311 aa)
JMJD8Jumonji domain containing 8. (268 aa)
jpt2Neurocalcin-delta. (192 aa)
uqcrc1Zinc finger protein, FOG family member 2. (432 aa)
MARCHF11Membrane associated ring-CH-type finger 11. (294 aa)
nifkMKI67 FHA domain-interacting nucleolar phosphoprotein-like. (204 aa)
srsf2Splicing factor, arginine/serine-rich 2. (220 aa)
F6UTD6_XENTRMAM domain-containing protein. (229 aa)
rbm22Pre-mRNA-splicing factor RBM22; Required for pre-mRNA splicing as component of the activated spliceosome. Involved in the first step of pre-mRNA splicing. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle. Belongs to the SLT11 family. (417 aa)
arhgef39BicC family RNA binding protein 1. (405 aa)
celf4CUGBP Elav-like family member 4; RNA-binding protein that may be implicated in the regulation of pre-mRNA alternative splicing; Belongs to the CELF/BRUNOL family. (307 aa)
sltm-2Carbonyl reductase family member 4. (402 aa)
srsf3Phosphate-regulating endopeptidase homolog X-linked. (164 aa)
ddx21Nuclear autoantigenic sperm protein (histone-binding). (758 aa)
hnrnpllATPase, Ca++ transporting, cardiac muscle, fast twitch 1. (531 aa)
ewsr1Uncharacterized protein. (673 aa)
rbm42RNA-binding protein 42; May bind RNA; Belongs to the RRM RBM42 family. (392 aa)
SPTBN5Spectrin beta, non-erythrocytic 5. (3355 aa)
puf60-2Uncharacterized protein. (607 aa)
puf60-3Uncharacterized protein. (580 aa)
hnrnpd-2Ig-like domain-containing protein. (607 aa)
tut1Speckle targeted PIP5K1A-regulated poly(A) polymerase; Poly(A) polymerase that creates the 3'-poly(A) tail of specific pre-mRNAs. In addition to polyadenylation, it is also required for the 3'-end cleavage of pre-mRNAs: binds to the 3'UTR of targeted pre-mRNAs and promotes the recruitment and assembly of the CPSF complex on the 3'UTR of pre-mRNAs. In addition to adenylyltransferase activity, also has uridylyltransferase activity. However, the ATP ratio is higher than UTP in cells, suggesting that it functions primarily as a poly(A) polymerase (By similarity); Belongs to the DNA polymer [...] (854 aa)
cpeb4Ig-like domain-containing protein. (116 aa)
rcan3SHC (Src homology 2 domain containing) family member 4. (235 aa)
hnrnpdlHeterogeneous nuclear ribonucleoprotein D-like; Acts as a transcriptional regulator. Binds DNA and RNA (By similarity). (319 aa)
esrp1Epithelial splicing regulatory protein 1; mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of fgfr2. Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of fgfr2 (By similarity); Belongs to the ESRP family. (687 aa)
snrnp70U1 small nuclear ribonucleoprotein 70 kDa; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. snrnp70 binds to the loop I region of U1- snRNA. (471 aa)
pabpn1lPoly(A) binding protein, nuclear 1. (218 aa)
snx12PX domain-containing protein. (237 aa)
rbm12b.1RNA binding motif protein 12. (418 aa)
isyna1AT-rich interaction domain 1B. (571 aa)
nonoNon-POU domain containing, octamer-binding. (465 aa)
celf1CUGBP Elav-like family member 1; RNA-binding protein implicated in the regulation of several post-transcriptional events. May be involved in pre-mRNA alternative splicing, mRNA translation activation and stability (By similarity). Mediates the rapid and sequence-specific cytoplasmic deadenylation of EDEN-containing maternal mRNAs following fertilization. Binds to AU- rich sequences (AREs) of jun mRNA. Binds to the embryonic deadenylation element (EDEN) motif localized in the 3'-UTR of maternal mRNAs. Binds to RNA containing several repeats of the consensus sequence 5'-UGU-3'. EDEN-depe [...] (517 aa)
srsf12Serine-arginine repressor protein (35 kDa). (253 aa)
larp7La-related protein 7; Negative transcriptional regulator of polymerase II genes, acting by means of the 7SK RNP system. Within the 7SK RNP complex, the positive transcription elongation factor b (P-TEFb) is sequestered in an inactive form, preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. (595 aa)
pabpc1lEmbryonic polyadenylate-binding protein; Binds and protects the poly(A) tail of mRNA with or without an AU-rich element (ARE) and prevents mRNA deadenylation. Stimulates the translation of mRNAs to which it is bound during early development (By similarity). (635 aa)
raver1LOC100158642 protein. (701 aa)
pabpn1Polyadenylate-binding protein 2; Involved in the 3'-end formation of mRNA precursors (pre- mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product. Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length. Increases the affinity of poly(A) polymerase for RNA. Binds to poly(A) and to poly(G) with high affinity. May protect the poly(A) tail from degradation. (296 aa)
cd82Tetraspanin. (268 aa)
foxn1Diphthamide biosynthesis 5. (583 aa)
eif3gEukaryotic translation initiation factor 3 subunit G; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA. (310 aa)
larp6-like.1Acheron. (481 aa)
rbm26-2Protein phosphatase, Mg2+/Mn2+ dependent 1E. (398 aa)
ncbp2Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U [...] (153 aa)
tp73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (632 aa)
srsf1Serine/arginine-rich splicing factor 1; May play a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Belongs to the splicing factor SR family. (272 aa)
srsf5Splicing factor, arginine/serine-rich 5. (272 aa)
elavl3ELAV-like protein 3; RNA-binding protein that binds to AU-rich sequences (AREs) of target mRNAs. May also bind poly-A tracts via RRM 3. May be involved in neuronal differentiation and maintenance (By similarity). (378 aa)
alkbh8Alkylated DNA repair protein alkB homolog 8; Catalyzes the methylation of 5-carboxymethyl uridine to 5- methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain. Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA. Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys). Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in [...] (663 aa)
mmaaEukaryotic translation initiation factor 5B. (409 aa)
celf2CUGBP Elav-like family member 2; RNA-binding protein implicated in the regulation of several post-transcriptional events. May be involved in pre-mRNA alternative splicing, mRNA translation repression and stability (By similarity). Belongs to the CELF/BRUNOL family. (545 aa)
rev1DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1235 aa)
bokPlexin A1. (214 aa)
nol8Ig-like domain-containing protein; Belongs to the MHC class I family. (295 aa)
ptbp25-hydroxytryptamine (serotonin) receptor 4, G protein-coupled. (531 aa)
hnrnpa1-3Kinesin family member 21B. (348 aa)
nup35Nucleoporin NUP35; Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors (By similarity); Belongs to the Nup35 family. (331 aa)
srek1-2Centromere protein E. (251 aa)
dnajc17-2Uncharacterized protein. (58 aa)
acin1VWFA domain-containing protein. (838 aa)
PKD2L1Polycystin 2 like 1, transient receptor potential cation channel. (684 aa)
rbm24RNA-binding protein 24; Multifunctional RNA-binding protein involved in the regulation of pre-mRNA splicing, mRNA stability and mRNA translation important for cell fate decision and differentiation. Plays a major role in pre-mRNA alternative splicing regulation. Mediates preferentially muscle-specific exon inclusion in numerous mRNAs important for striated cardiac and skeletal muscle cell differentiation. Binds to intronic splicing enhancer (ISE) composed of stretches of GU-rich motifs localized in flanking intron of exon that will be included by alternative splicing. Involved in embry [...] (226 aa)
ppil4Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. (471 aa)
sp6Spermine oxidase. (357 aa)
hnrnpa3Deuterosome assembly protein 1. (383 aa)
dazlDeleted in azoospermia-like; RNA-binding protein that is required for primordial germ cell (PGC) differentiation and indirectly necessary for the migration of PGCs through the endoderm. May promote meiotic cell division during spermatogenesis. Shows a preference for G- and U-rich RNAs and probably binds the 3'-UTR of target mRNAs. Stimulates the initiation of translation of mRNAs through the recruitment of poly(A)-binding proteins (PABPs) (By similarity). (286 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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