(26 nodes) (2015) Non-mammalian models in behavioral neuroscience: consequences for biological psychiatry. network (Xenopus tropicalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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Predicted Interactions

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gene fusions

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Your Input:
	fgf22	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (175 aa)
	fgf6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (195 aa)
	fgf10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)
	hcrt	L3MBTL3, histone methyl-lysine binding protein. (143 aa)
	fgf4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (192 aa)
	fgf19	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (215 aa)
	fgf9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	fgf20	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (274 aa)
	NOS1	Nitric oxide synthase; Produces nitric oxide (NO). (1420 aa)
	fgf8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
	npy	Neuropeptide Y. (97 aa)
	fgf14	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (247 aa)
	FGF5	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (251 aa)
	fgf2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (154 aa)
	fgf3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (236 aa)
	LOC101731237	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (132 aa)
	nos3	Nitric oxide synthase; Produces nitric oxide (NO). (1113 aa)
	LOC105947943	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (193 aa)
	fgf16	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (202 aa)
	fgf13	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
	fgf1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
	nos2	Nitric oxide synthase; Produces nitric oxide (NO). (1172 aa)
	fgf7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
	sst.1	Somatostatin domain-containing protein. (115 aa)
	ACHE	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (600 aa)
	fgf12	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)

Your Current Organism:

Xenopus tropicalis

NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACHE	npy	ENSXETP00000042867	ENSXETP00000020189	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.	Neuropeptide Y.	0.418
FGF5	fgf8	ENSXETP00000013289	ENSXETP00000020361	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.461
LOC105947943	fgf19	ENSXETP00000006506	ENSXETP00000034369	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.459
NOS1	nos3	ENSXETP00000021775	ENSXETP00000008388	Nitric oxide synthase; Produces nitric oxide (NO).	Nitric oxide synthase; Produces nitric oxide (NO).	0.901
fgf19	LOC105947943	ENSXETP00000034369	ENSXETP00000006506	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.459
fgf19	fgf4	ENSXETP00000034369	ENSXETP00000034381	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.580
fgf19	fgf8	ENSXETP00000034369	ENSXETP00000020361	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.503
fgf2	fgf22	ENSXETP00000012401	ENSXETP00000010222	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.578
fgf2	fgf4	ENSXETP00000012401	ENSXETP00000034381	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.498
fgf22	fgf2	ENSXETP00000010222	ENSXETP00000012401	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.578
fgf22	fgf4	ENSXETP00000010222	ENSXETP00000034381	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.515
fgf22	fgf8	ENSXETP00000010222	ENSXETP00000020361	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.413
fgf3	fgf8	ENSXETP00000011817	ENSXETP00000020361	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.682
fgf4	fgf19	ENSXETP00000034381	ENSXETP00000034369	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.580
fgf4	fgf2	ENSXETP00000034381	ENSXETP00000012401	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.498
fgf4	fgf22	ENSXETP00000034381	ENSXETP00000010222	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.515
fgf4	fgf8	ENSXETP00000034381	ENSXETP00000020361	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.480
fgf8	FGF5	ENSXETP00000020361	ENSXETP00000013289	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.461
fgf8	fgf19	ENSXETP00000020361	ENSXETP00000034369	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.503
fgf8	fgf22	ENSXETP00000020361	ENSXETP00000010222	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.413

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