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lrch2-2 lrch2-2 h3c13-13 h3c13-13 h3c13-15 h3c13-15 cdc20b cdc20b mcidas mcidas notch1 notch1 ctrl ctrl crocc2 crocc2 ctrb2 ctrb2 tbl1x tbl1x h3c13 h3c13 ENSXETP00000002330 ENSXETP00000002330 h3c13-2 h3c13-2 h3c13-4 h3c13-4 h3c13-5 h3c13-5 h3-3b h3-3b gja7-2 gja7-2 h3c13-6 h3c13-6 h3c13-7 h3c13-7 h3c13-9 h3c13-9 h3c13-10 h3c13-10 h3c13-11 h3c13-11
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
lrch2-2Histone H3; Belongs to the histone H3 family. (124 aa)
h3c13-13Histone H3. (136 aa)
h3c13-15Histone H3. (136 aa)
cdc20bVPS54 GARP complex subunit. (519 aa)
mcidasMulticilin; Transcription regulator specifically required for multiciliate cell differentiation. Acts in a multiprotein complex containing e2f4 and e2f5 that binds and activate genes required for centriole biogenesis. Activates genes required for centriole assembly (plk4, cep152) and genes specifically required for motile cilia formation (foxj1). Also promotes the deuterosome pathway of centriole biogenesis by activating expression of deup1, but not its paralog cep63; Belongs to the geminin family. (376 aa)
notch1Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] (2535 aa)
ctrlChymotrypsinogen B1; Belongs to the peptidase S1 family. (263 aa)
crocc2Phosphoglucomutase 2. (1978 aa)
ctrb2Phosphoprotein membrane anchor with glycosphingolipid microdomains 1; Belongs to the peptidase S1 family. (263 aa)
tbl1xUncharacterized protein. (565 aa)
h3c13Histone H3.2; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (136 aa)
ENSXETP00000002330Histone H3; Belongs to the histone H3 family. (136 aa)
h3c13-2Histone H3. (136 aa)
h3c13-4Histone H3. (136 aa)
h3c13-5Histone H3. (136 aa)
h3-3bHistone H3.3; Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in [...] (136 aa)
gja7-2Histone H3; Belongs to the histone H3 family. (135 aa)
h3c13-6Histone H3. (136 aa)
h3c13-7Histone H3. (136 aa)
h3c13-9Histone H3. (136 aa)
h3c13-10Histone H3. (136 aa)
h3c13-11Histone H3. (136 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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