(23 nodes) (2021) Biomimetics provides lessons from nature for contemporary ways to improve human health. network (Xenopus tropicalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

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gene fusions

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textmining

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protein homology

Your Input:
	trpa1	Transient receptor potential ankyrin 1; Belongs to the transient receptor (TC 1.A.4) family. (1144 aa)
	fgf22	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (175 aa)
	LOC105947943	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (193 aa)
	fgf8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
	fgf14	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (247 aa)
	fgf2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (154 aa)
	FGF5	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (251 aa)
	fgf3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (236 aa)
	LOC101731237	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (132 aa)
	fgf16	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (202 aa)
	fgf13	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
	fgf1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
	fgf7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
	abca4-3	ATP binding cassette subfamily A member 4. (174 aa)
	rasl11a	Aph-1 homolog A, gamma secretase subunit. (239 aa)
	fgf19	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (215 aa)
	fgf20	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (274 aa)
	fgf9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	fgf4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (192 aa)
	fgf10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)
	fgf6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (195 aa)
	fgf12	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)
	nfe2l2	Similar to nfe2l2 (Nuclear factor (Erythroid-derived 2)-like 2). (589 aa)

Your Current Organism:

Xenopus tropicalis

NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FGF5	abca4-3	ENSXETP00000013289	ENSXETP00000028683	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	ATP binding cassette subfamily A member 4.	0.468
FGF5	fgf8	ENSXETP00000013289	ENSXETP00000020361	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.461
LOC101731237	abca4-3	ENSXETP00000011624	ENSXETP00000028683	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	ATP binding cassette subfamily A member 4.	0.413
LOC105947943	abca4-3	ENSXETP00000006506	ENSXETP00000028683	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	ATP binding cassette subfamily A member 4.	0.409
LOC105947943	fgf19	ENSXETP00000006506	ENSXETP00000034369	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.459
abca4-3	FGF5	ENSXETP00000028683	ENSXETP00000013289	ATP binding cassette subfamily A member 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.468
abca4-3	LOC101731237	ENSXETP00000028683	ENSXETP00000011624	ATP binding cassette subfamily A member 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.413
abca4-3	LOC105947943	ENSXETP00000028683	ENSXETP00000006506	ATP binding cassette subfamily A member 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.409
abca4-3	fgf4	ENSXETP00000028683	ENSXETP00000034381	ATP binding cassette subfamily A member 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.472
abca4-3	fgf6	ENSXETP00000028683	ENSXETP00000038450	ATP binding cassette subfamily A member 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.410
abca4-3	fgf7	ENSXETP00000028683	ENSXETP00000054080	ATP binding cassette subfamily A member 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.413
abca4-3	rasl11a	ENSXETP00000028683	ENSXETP00000033174	ATP binding cassette subfamily A member 4.	Aph-1 homolog A, gamma secretase subunit.	0.423
fgf19	LOC105947943	ENSXETP00000034369	ENSXETP00000006506	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.459
fgf19	fgf4	ENSXETP00000034369	ENSXETP00000034381	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.580
fgf19	fgf8	ENSXETP00000034369	ENSXETP00000020361	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.503
fgf2	fgf22	ENSXETP00000012401	ENSXETP00000010222	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.578
fgf2	fgf4	ENSXETP00000012401	ENSXETP00000034381	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.498
fgf22	fgf2	ENSXETP00000010222	ENSXETP00000012401	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.578
fgf22	fgf4	ENSXETP00000010222	ENSXETP00000034381	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.515
fgf22	fgf8	ENSXETP00000010222	ENSXETP00000020361	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.413

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