(9 nodes) (2023) Tebuconazole Induces ER-Stress-Mediated Cell Death in Bovine Mammary Epithelial Cell Lines. network (Xenopus tropicalis)

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Your Input:
	cars2	Hypothetical protein LOC594893. (609 aa)
	hif1a-2	Caveolin 1. (183 aa)
	pxdn	Peroxidasin. (1546 aa)
	casp3.1	Uncharacterized protein; Belongs to the peptidase C14A family. (276 aa)
	ero1a	ERO1-like protein alpha; Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the folding of immunoglobulins (By similarity). Belongs to the EROs family. (475 aa)
	casp8	S-adenosylmethionine sensor upstream of mTORC1; Belongs to the peptidase C14A family. (504 aa)
	actb	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa)
	casp3.2	Uncharacterized protein; Belongs to the peptidase C14A family. (288 aa)
	gapdh	Glyceraldehyde-3-phosphate dehydrogenase. (364 aa)

Your Current Organism:

Xenopus tropicalis

NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
actb	cars2	ENSXETP00000001302	ENSXETP00000031638	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Hypothetical protein LOC594893.	0.494
actb	casp3.1	ENSXETP00000001302	ENSXETP00000015569	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.945
actb	casp3.2	ENSXETP00000001302	ENSXETP00000000365	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.945
actb	gapdh	ENSXETP00000001302	ENSXETP00000036173	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Glyceraldehyde-3-phosphate dehydrogenase.	0.761
actb	hif1a-2	ENSXETP00000001302	ENSXETP00000031610	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Caveolin 1.	0.495
actb	pxdn	ENSXETP00000001302	ENSXETP00000021136	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Peroxidasin.	0.534
cars2	actb	ENSXETP00000031638	ENSXETP00000001302	Hypothetical protein LOC594893.	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	0.494
cars2	casp3.1	ENSXETP00000031638	ENSXETP00000015569	Hypothetical protein LOC594893.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.503
cars2	casp3.2	ENSXETP00000031638	ENSXETP00000000365	Hypothetical protein LOC594893.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.504
cars2	gapdh	ENSXETP00000031638	ENSXETP00000036173	Hypothetical protein LOC594893.	Glyceraldehyde-3-phosphate dehydrogenase.	0.604
cars2	pxdn	ENSXETP00000031638	ENSXETP00000021136	Hypothetical protein LOC594893.	Peroxidasin.	0.694
casp3.1	actb	ENSXETP00000015569	ENSXETP00000001302	Uncharacterized protein; Belongs to the peptidase C14A family.	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	0.945
casp3.1	cars2	ENSXETP00000015569	ENSXETP00000031638	Uncharacterized protein; Belongs to the peptidase C14A family.	Hypothetical protein LOC594893.	0.503
casp3.1	casp3.2	ENSXETP00000015569	ENSXETP00000000365	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.905
casp3.1	casp8	ENSXETP00000015569	ENSXETP00000006109	Uncharacterized protein; Belongs to the peptidase C14A family.	S-adenosylmethionine sensor upstream of mTORC1; Belongs to the peptidase C14A family.	0.956
casp3.1	gapdh	ENSXETP00000015569	ENSXETP00000036173	Uncharacterized protein; Belongs to the peptidase C14A family.	Glyceraldehyde-3-phosphate dehydrogenase.	0.484
casp3.1	hif1a-2	ENSXETP00000015569	ENSXETP00000031610	Uncharacterized protein; Belongs to the peptidase C14A family.	Caveolin 1.	0.503
casp3.1	pxdn	ENSXETP00000015569	ENSXETP00000021136	Uncharacterized protein; Belongs to the peptidase C14A family.	Peroxidasin.	0.625
casp3.2	actb	ENSXETP00000000365	ENSXETP00000001302	Uncharacterized protein; Belongs to the peptidase C14A family.	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	0.945
casp3.2	cars2	ENSXETP00000000365	ENSXETP00000031638	Uncharacterized protein; Belongs to the peptidase C14A family.	Hypothetical protein LOC594893.	0.504

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