STRINGSTRING
tgm2 tgm2 prl.2 prl.2 lgr5 lgr5 cxcl14-2 cxcl14-2 ezh2 ezh2 ENSXETP00000011359 ENSXETP00000011359 ecm1 ecm1 prl.1 prl.1 MMP11 MMP11 nr2f2 nr2f2 myos myos lep lep cyp26b1 cyp26b1 astl astl pifo pifo cfd cfd snai1 snai1 mrpl27 mrpl27 Cdhr3 Cdhr3 uggt2 uggt2 wnt5a wnt5a hoxb8 hoxb8 emsy emsy mt4 mt4 dazl dazl fap fap inhbc.1 inhbc.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
tgm2DH domain-containing protein. (1819 aa)
prl.2NLR family, pyrin domain-containing 3. (219 aa)
lgr5Leucine-rich repeat-containing G-protein coupled receptor 5; Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the [...] (902 aa)
cxcl14-2Chemokine (C-X-C motif) ligand 14. (173 aa)
ezh2Histone-lysine N-methyltransferase EZH2; Polycomb group (PcG) protein. Catalytic subunit of the prc2/eed-ezh2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. May regulate the circadian clock via histone methylation at the promoter of the circadian genes; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. EZ subfamily. (763 aa)
ENSXETP00000011359Uncharacterized protein. (183 aa)
ecm1O-phosphoseryl-tRNA(Sec) selenium transferase. (455 aa)
prl.1Alanine aminotransferase 2. (230 aa)
MMP11Matrix metallopeptidase 11. (478 aa)
nr2f2Nr2f2 protein. (408 aa)
myosChromosome 20 open reading frame 85. (814 aa)
lepLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. (169 aa)
cyp26b1Cytochrome P450 26B1; Plays a key role in retinoic acid metabolism. Appears to be involved in the inactivation of all-trans-retinoic acid (RA). (472 aa)
astlMetalloendopeptidase. (226 aa)
pifoUncharacterized protein. (192 aa)
cfdSerine protease ami; Probable serine protease; Belongs to the peptidase S1 family. (266 aa)
snai1Uncharacterized protein. (336 aa)
mrpl27HOP homeobox. (136 aa)
Cdhr3Uncharacterized protein. (139 aa)
uggt2Insulin like growth factor binding protein 5. (1517 aa)
wnt5aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (402 aa)
hoxb8Regulating synaptic membrane exocytosis 3. (243 aa)
emsyMetallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (62 aa)
mt4Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (64 aa)
dazlDeleted in azoospermia-like; RNA-binding protein that is required for primordial germ cell (PGC) differentiation and indirectly necessary for the migration of PGCs through the endoderm. May promote meiotic cell division during spermatogenesis. Shows a preference for G- and U-rich RNAs and probably binds the 3'-UTR of target mRNAs. Stimulates the initiation of translation of mRNAs through the recruitment of poly(A)-binding proteins (PABPs) (By similarity). (286 aa)
fapUncharacterized protein; Belongs to the peptidase S9B family. (776 aa)
inhbc.1Piwi-like RNA-mediated gene silencing 4. (367 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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