(75 nodes) PHD zinc finger network (Xenopus tropicalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	KDM2B	Uncharacterized protein. (1263 aa)
	ing2	Inhibitor of growth protein. (279 aa)
	kdm7a	Lysine-specific demethylase 7A; Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code (By similarity); Belongs to the JHDM1 histone demethylase family. JHDM1D subfamily. (912 aa)
	phf13	PHD domain-containing protein. (341 aa)
	ING4	Inhibitor of growth protein. (288 aa)
	rsf1	Sterol O-acyltransferase 2. (1424 aa)
	JADE2	Uncharacterized protein. (853 aa)
	kmt2d	Chromosome 1 open reading frame 50. (6079 aa)
	PHF3	Uncharacterized protein. (1926 aa)
	kdm4a	LOC100135350 protein. (1006 aa)
	ints12	Integrator complex subunit 12; Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'- box-dependent processing. (470 aa)
	kdm5c	Leucine zipper protein 1. (1528 aa)
	kmt2b	Uncharacterized protein. (2817 aa)
	brd1	Bromodomain-containing 1. (1185 aa)
	NSD1	Nuclear receptor binding SET domain protein 1. (2450 aa)
	TCF20	Transcription factor 20. (1870 aa)
	aire	PHD-type domain-containing protein. (403 aa)
	fbxl19	GULP PTB domain containing engulfment adaptor 1. (422 aa)
	PHF21B	PHD finger protein 21B. (629 aa)
	zmynd8	Uncharacterized protein. (1216 aa)
	chd4	SON DNA binding protein. (1889 aa)
	dpf1	Uncharacterized protein. (405 aa)
	rnf32	G protein-coupled receptor 150. (382 aa)
	LOC100492657	PHD-type domain-containing protein. (553 aa)
	phf11	DnaJ heat shock protein family (Hsp40) member C8. (278 aa)
	phf12	Uncharacterized protein. (999 aa)
	CXXC1	CXXC finger protein 1. (625 aa)
	kmt2c	RAB9B, member RAS oncogene family. (4527 aa)
	phf19	Chromosome 6 open reading frame 203. (531 aa)
	dido1	UPF3A, regulator of nonsense mediated mRNA decay. (2281 aa)
	trim24	Uncharacterized protein. (1040 aa)
	ing5	Inhibitor of growth protein. (236 aa)
	nsmce1	Non-structural maintenance of chromosomes element 1 homolog; RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Within MAGE-RING ubiquitin ligase complex, MAGE stimulates and specifies ubiquitin ligase activity likely through recruitment and/or stabilization of the E2 ubiquitin-conjugating enzyme at the E3:substrate complex. Involved in maintenance of genome integrity, DNA damage response and DNA repair. Belongs to the NSE1 family. (270 aa)
	ubr7	Pre-B-cell leukemia transcription factor 1. (411 aa)
	TAF3	TATA-box binding protein associated factor 3. (929 aa)
	PHF20L1	PHD finger protein 20 like 1. (889 aa)
	phf8	Gigaxonin. (1005 aa)
	PHF1	PHD finger protein 1. (544 aa)
	KMT2E	Lysine methyltransferase 2E. (1800 aa)
	shprh	Pyridine nucleotide-disulphide oxidoreductase domain 2. (1189 aa)
	phf14	Uncharacterized protein. (943 aa)
	phf6	TGFB induced factor homeobox 2. (363 aa)
	ing3	Inhibitor of growth protein 3; Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription (By similarity). NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage (By similarity); Belongs to the ING family. (417 aa)
	mllt6	Uncharacterized protein. (937 aa)
	MLLT10	MLLT10 histone lysine methyltransferase DOT1L cofactor. (1025 aa)
	BAZ1A	Bromodomain adjacent to zinc finger domain 1A. (1570 aa)
	brpf3	LOC779492 protein. (983 aa)
	NSD3	Nuclear receptor binding SET domain protein 3. (1451 aa)
	mtf2	PHD-type domain-containing protein. (594 aa)
	brpf1	Uncharacterized protein. (1273 aa)
	G2E3	G2/M-phase specific E3 ubiquitin protein ligase. (667 aa)
	kdm4c	LOC100127653 protein. (1066 aa)
	BAZ2B	Bromodomain adjacent to zinc finger domain 2B. (2182 aa)
	BAZ2A	Bromodomain adjacent to zinc finger domain 2A. (1701 aa)
	dpf3	Vacuolar protein sorting 37 homolog A. (387 aa)
	ing1	Inhibitor of growth protein. (279 aa)
	chd5	HNF1 homeobox B. (1782 aa)
	kdm2a	Lysine-specific demethylase 2A; Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the c [...] (1146 aa)
	kdm5b	Lysosomal-associated membrane protein 2. (1527 aa)
	rgn	Protein Jade-3; May regulate histone acetylation. (884 aa)
	TRIM33	Uncharacterized protein. (1219 aa)
	PHF20	PHD finger protein 20. (987 aa)
	kmt2a	Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily. (3664 aa)
	kdm5a	Elongator complex protein 1. (1607 aa)
	CHD3	Chromodomain helicase DNA binding protein 3. (2035 aa)
	rai1	Latent transforming growth factor beta binding protein 3. (1847 aa)
	phf10	Uncharacterized protein. (541 aa)
	kdm4b	Uncharacterized protein. (1025 aa)
	sp110	Uncharacterized protein. (336 aa)
	dpf2	Uncharacterized protein. (406 aa)
	zmynd11	Zmynd11 protein. (622 aa)
	jade1	Complement factor properdin. (833 aa)
	PYGO1	Pygopus family PHD finger 1. (506 aa)
	bptf	Anillin actin binding protein. (3008 aa)
	NSD2	Nuclear receptor binding SET domain protein 2. (1308 aa)

Your Current Organism:

Xenopus tropicalis

NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BAZ1A	phf8	ENSXETP00000051238	ENSXETP00000046845	Bromodomain adjacent to zinc finger domain 1A.	Gigaxonin.	0.800
CXXC1	kmt2c	ENSXETP00000039061	ENSXETP00000039191	CXXC finger protein 1.	RAB9B, member RAS oncogene family.	0.428
CXXC1	kmt2d	ENSXETP00000039061	ENSXETP00000019512	CXXC finger protein 1.	Chromosome 1 open reading frame 50.	0.428
ING4	JADE2	ENSXETP00000017308	ENSXETP00000018562	Inhibitor of growth protein.	Uncharacterized protein.	0.567
ING4	brd1	ENSXETP00000017308	ENSXETP00000031174	Inhibitor of growth protein.	Bromodomain-containing 1.	0.502
ING4	brpf1	ENSXETP00000017308	ENSXETP00000052453	Inhibitor of growth protein.	Uncharacterized protein.	0.589
ING4	brpf3	ENSXETP00000017308	ENSXETP00000051302	Inhibitor of growth protein.	LOC779492 protein.	0.522
ING4	jade1	ENSXETP00000017308	ENSXETP00000012879	Inhibitor of growth protein.	Complement factor properdin.	0.595
ING4	rgn	ENSXETP00000017308	ENSXETP00000004824	Inhibitor of growth protein.	Protein Jade-3; May regulate histone acetylation.	0.418
JADE2	ING4	ENSXETP00000018562	ENSXETP00000017308	Uncharacterized protein.	Inhibitor of growth protein.	0.567
JADE2	ing3	ENSXETP00000018562	ENSXETP00000050369	Uncharacterized protein.	Inhibitor of growth protein 3; Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription (By similarity). NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage (By similarity); Belongs to the ING family.	0.514
JADE2	ing5	ENSXETP00000018562	ENSXETP00000044253	Uncharacterized protein.	Inhibitor of growth protein.	0.567
KMT2E	PHF3	ENSXETP00000047912	ENSXETP00000022103	Lysine methyltransferase 2E.	Uncharacterized protein.	0.442
NSD1	bptf	ENSXETP00000031454	ENSXETP00000014160	Nuclear receptor binding SET domain protein 1.	Anillin actin binding protein.	0.425
NSD1	rai1	ENSXETP00000031454	ENSXETP00000006990	Nuclear receptor binding SET domain protein 1.	Latent transforming growth factor beta binding protein 3.	0.402
PHF20	ing1	ENSXETP00000005423	ENSXETP00000001312	PHD finger protein 20.	Inhibitor of growth protein.	0.821
PHF3	KMT2E	ENSXETP00000022103	ENSXETP00000047912	Uncharacterized protein.	Lysine methyltransferase 2E.	0.442
PHF3	bptf	ENSXETP00000022103	ENSXETP00000014160	Uncharacterized protein.	Anillin actin binding protein.	0.638
TAF3	bptf	ENSXETP00000045230	ENSXETP00000014160	TATA-box binding protein associated factor 3.	Anillin actin binding protein.	0.495
TAF3	ing2	ENSXETP00000045230	ENSXETP00000014897	TATA-box binding protein associated factor 3.	Inhibitor of growth protein.	0.538

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