STRINGSTRING
NYX NYX lrfn4 lrfn4 lrrc32.1 lrrc32.1 IGFALS IGFALS PHLPP2 PHLPP2 RXFP1 RXFP1 lrrc28 lrrc28 tsku tsku TRIL TRIL LOC100485164 LOC100485164 rtn4rl2 rtn4rl2 flrt2 flrt2 vasn vasn LRIG3 LRIG3 lgr5 lgr5 lrrc30 lrrc30 SLITRK5 SLITRK5 lrrc4b lrrc4b LOC101733155 LOC101733155 mxra5 mxra5 slit1 slit1 LRRTM4 LRRTM4 flrt1 flrt1 lgi4 lgi4 rsu1 rsu1 scaf8 scaf8 fmod fmod mfap4 mfap4 LOC101730428 LOC101730428 lrrc8a lrrc8a slitrk2 slitrk2 SLITRK4 SLITRK4 nprl2-2 nprl2-2 tmem115-2 tmem115-2 apmapl-2 apmapl-2 ecm2.2 ecm2.2 ENSXETP00000016814 ENSXETP00000016814 lrig1 lrig1 LRRC4C LRRC4C nrros nrros LOC100486968 LOC100486968 LOC100497009 LOC100497009 mamdc2-3 mamdc2-3 omg omg shoc2 shoc2 LRRD1 LRRD1 LRRK1 LRRK1 tlr3 tlr3 lrit2 lrit2 pxdn pxdn lingo4 lingo4 lrrc57 lrrc57 OGN OGN ASPN ASPN lrfn2 lrfn2 chadl chadl lgr4 lgr4 LRFN1 LRFN1 flrt3 flrt3 amigo2 amigo2 tpbg tpbg igsf10 igsf10 slit3 slit3 lrrc8e lrrc8e LRRC10 LRRC10 lrrc8e.2 lrrc8e.2 slitrk1 slitrk1 slitrk6 slitrk6 lrrc39 lrrc39 lrrc4 lrrc4 ENSXETP00000033260 ENSXETP00000033260 Lrrc38 Lrrc38 LOC100485201 LOC100485201 ENSXETP00000034105 ENSXETP00000034105 lrit3 lrit3 LRRC24 LRRC24 lrrc47 lrrc47 slit2 slit2 lingo1 lingo1 rtn4rl1 rtn4rl1 lrfn3 lrfn3 tspan2-2 tspan2-2 lrrtm1 lrrtm1 LOC100488097 LOC100488097 PODN PODN LOC100495962 LOC100495962 tlr7 tlr7 lrrn3 lrrn3 RXFP2 RXFP2 LRRC27 LRRC27 lgi2 lgi2 cnot6l cnot6l mfhas1 mfhas1 ADGRA3 ADGRA3 LINGO2 LINGO2 chad chad PIDD1 PIDD1 ADGRA2 ADGRA2 LRRC18 LRRC18 LOC100489423 LOC100489423 LOC100485706 LOC100485706 LRRN1 LRRN1 slitrk3 slitrk3 lrrc3b lrrc3b lgi1 lgi1 lrch2 lrch2 lum lum dcn dcn ENSXETP00000047973 ENSXETP00000047973 Lrrc19 Lrrc19 LRIG2 LRIG2 LRRTM3 LRRTM3 LOC100485206 LOC100485206 lrtm2 lrtm2 LRFN5 LRFN5 lrrc40 lrrc40 LOC100170560 LOC100170560 lrrc8d lrrc8d lrrc8c lrrc8c eva1a-2 eva1a-2 AMIGO3 AMIGO3 cyb5b-2 cyb5b-2 Lrg1 Lrg1 lrwd1 lrwd1 lrrc69 lrrc69
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NYXNyctalopin. (447 aa)
lrfn4Uncharacterized protein. (722 aa)
lrrc32.15-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled. (666 aa)
IGFALSInsulin like growth factor binding protein acid labile subunit. (601 aa)
PHLPP2PH domain and leucine rich repeat protein phosphatase 2. (1335 aa)
RXFP1Relaxin family peptide receptor 1. (714 aa)
lrrc28Leucine-rich repeat-containing protein 28. (367 aa)
tskuTsukushin; Dorsalizing factor. Functions as an inhibitor of bone morphogenetic proteins (BMP) during gastrulation (By similarity). (350 aa)
TRILTLR4 interactor with leucine rich repeats. (872 aa)
LOC100485164TIR domain-containing protein. (958 aa)
rtn4rl2Uncharacterized protein. (396 aa)
flrt2Wnt family member 1. (691 aa)
vasnVasorin; May act as an inhibitor of TGF-beta signaling. (673 aa)
LRIG3Leucine rich repeats and immunoglobulin like domains 3. (1110 aa)
lgr5Leucine-rich repeat-containing G-protein coupled receptor 5; Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the [...] (902 aa)
lrrc30Golgin A7. (290 aa)
SLITRK5SLIT and NTRK like family member 5. (881 aa)
lrrc4bLOC100124949 protein. (641 aa)
LOC101733155Uncharacterized protein. (320 aa)
mxra5NEDD4 E3 ubiquitin protein ligase. (2741 aa)
slit1Slit1 protein. (1529 aa)
LRRTM4Leucine rich repeat transmembrane neuronal 4. (622 aa)
flrt1Activating transcription factor 3. (679 aa)
lgi4LRRCT domain-containing protein. (578 aa)
rsu1RAS (RAD and GEM)-like GTP binding 2. (277 aa)
scaf8SR-related CTD associated factor 8. (307 aa)
fmodBiglycan. (357 aa)
mfap4Pancreatic lipase-related protein 3. (881 aa)
LOC101730428Uncharacterized protein. (970 aa)
lrrc8aCWC27 spliceosome-associated protein. (809 aa)
slitrk2NADH:ubiquinone oxidoreductase subunit A6. (846 aa)
SLITRK4SLIT and NTRK like family member 4. (851 aa)
nprl2-2NPR2 like, GATOR1 complex subunit. (635 aa)
tmem115-2Transmembrane protein 115. (588 aa)
apmapl-2Uncharacterized protein. (758 aa)
ecm2.2R-spondin 3. (515 aa)
ENSXETP00000016814LRRCT domain-containing protein. (581 aa)
lrig1RAR related orphan receptor C. (1043 aa)
LRRC4CLeucine rich repeat containing 4C. (639 aa)
nrrosCytoskeleton associated protein 5. (679 aa)
LOC100486968Apoptosis-associated speck-like protein containing a CARD. (472 aa)
LOC100497009Phosphoglucomutase 5. (928 aa)
mamdc2-3MAM domain containing 2. (782 aa)
omgUncharacterized protein. (268 aa)
shoc2Uncharacterized protein. (582 aa)
LRRD1Leucine rich repeats and death domain containing 1. (757 aa)
LRRK1Leucine rich repeat kinase 1. (2003 aa)
tlr3TIR domain-containing protein; Belongs to the Toll-like receptor family. (917 aa)
lrit2Butyrophilin like 2. (478 aa)
pxdnPeroxidasin. (1546 aa)
lingo4Ig-like domain-containing protein. (626 aa)
lrrc57Iroquois-class homeodomain protein irx-3. (238 aa)
OGNOsteoglycin. (294 aa)
ASPNAsporin. (378 aa)
lrfn2RRN3 homolog, RNA polymerase I transcription factor. (765 aa)
chadlUncharacterized protein. (721 aa)
lgr4Leucine-rich repeat-containing G-protein coupled receptor 4; Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Its function as activat [...] (956 aa)
LRFN1Leucine rich repeat and fibronectin type III domain containing 1. (742 aa)
flrt3Leucine-rich repeat transmembrane protein FLRT3; Functions in cell-cell adhesion, cell migration and axon guidance, exerting an attractive or repulsive role depending on its interaction partners (By similarity). Modulates cadherin-dependent cell-cell adhesion and cell sorting (By similarity). Plays a role in the spatial organization of brain neurons. Plays a role in vascular development. Plays a role in cell-cell adhesion via its interaction with latrophilins that are expressed at the surface of adjacent cells. Mediates axon attraction towards cells expressing ntn1. mediates axon growt [...] (648 aa)
amigo2SPHK1 interactor, AKAP domain containing. (518 aa)
tpbgVascular endothelial growth factor D. (404 aa)
igsf10Ribosomal protein S2. (2876 aa)
slit3ZXD family zinc finger C. (1519 aa)
lrrc8eVolume-regulated anion channel subunit LRRC8E; Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. Mediates efflux of amino acids, such as aspartate, in response to osmotic stress. Channel activity requires lrrc8a plus at least one other family member (lrrc8b, lrrc8c, lrrc8d or lrrc8e); channel characteristics depen [...] (806 aa)
LRRC10Leucine rich repeat containing 10. (284 aa)
lrrc8e.2Pannexin_like domain-containing protein. (779 aa)
slitrk1LOC100124997 protein. (696 aa)
slitrk6Fibromodulin. (826 aa)
lrrc39Uncharacterized protein. (325 aa)
lrrc4Ig-like domain-containing protein. (641 aa)
ENSXETP00000033260Leucine zipper putative tumor suppressor 2 homolog. (473 aa)
Lrrc38LRRCT domain-containing protein. (287 aa)
LOC100485201TIR domain-containing protein. (854 aa)
ENSXETP00000034105Uncharacterized protein. (252 aa)
lrit3Guanylate cyclase activator 1A like. (654 aa)
LRRC24Leucine rich repeat containing 24. (408 aa)
lrrc47LOC100145802 protein. (570 aa)
slit2ATPase family, AAA domain containing 3A. (1564 aa)
lingo1Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1; May play a role in regulating axonal regeneration and plasticity in the adult central nervous system. (606 aa)
rtn4rl1LRRCT domain-containing protein. (461 aa)
lrfn3Ornithine decarboxylase antizyme 1. (660 aa)
tspan2-2Adaptor related protein complex 1 subunit mu 1. (634 aa)
lrrtm1Cerebellar degeneration-related protein 2-like. (521 aa)
LOC100488097Fibronectin type-III domain-containing protein. (660 aa)
PODNPodocan. (598 aa)
LOC100495962TIR domain-containing protein; Belongs to the Toll-like receptor family. (1030 aa)
tlr7WW domain containing E3 ubiquitin protein ligase 2; Belongs to the Toll-like receptor family. (1054 aa)
lrrn3Leucine rich repeat neuronal 3. (706 aa)
RXFP2Relaxin family peptide receptor 2. (696 aa)
LRRC27Leucine rich repeat containing 27. (440 aa)
lgi2Sodium channel, voltage gated, type II alpha subunit. (538 aa)
cnot6lHepatocyte nuclear factor 4 gamma. (587 aa)
mfhas1Malignant fibrous histiocytoma-amplified sequence 1 homolog; Probable GTP-binding protein. Functions in innate immunity and more specifically the inflammatory response as a regulator of the Toll-like receptor TLR2 and TLR4 signaling pathways. (999 aa)
ADGRA3Adhesion G protein-coupled receptor A3; Belongs to the G-protein coupled receptor 2 family. (1313 aa)
LINGO2Leucine rich repeat and Ig domain containing 2. (612 aa)
chadUncharacterized protein. (360 aa)
PIDD1P53-induced death domain protein 1. (908 aa)
ADGRA2Adhesion G protein-coupled receptor A2; Belongs to the G-protein coupled receptor 2 family. (1304 aa)
LRRC18Leucine rich repeat containing 18. (257 aa)
LOC100489423ADAM metallopeptidase domain 23. (652 aa)
LOC100485706TIR domain-containing protein; Belongs to the Toll-like receptor family. (916 aa)
LRRN1Leucine rich repeat neuronal 1. (718 aa)
slitrk3Chitinase domain-containing protein 1. (885 aa)
lrrc3bSolute carrier family 6 (neutral amino acid transporter), member 15. (259 aa)
lgi1Leucine-rich, glioma inactivated 1. (547 aa)
lrch2Leucine-rich repeats and calponin homology (CH) domain containing 1. (748 aa)
lumDecapping enzyme, scavenger. (370 aa)
dcnDecorin; May affect the rate of fibrils formation. (364 aa)
ENSXETP00000047973LRRNT domain-containing protein. (506 aa)
Lrrc19Uncharacterized protein. (239 aa)
LRIG2Leucine rich repeats and immunoglobulin like domains 2. (1078 aa)
LRRTM3Leucine rich repeat transmembrane neuronal 3. (514 aa)
LOC100485206Pannexin_like domain-containing protein. (780 aa)
lrtm2Uncharacterized protein. (356 aa)
LRFN5Leucine rich repeat and fibronectin type III domain containing 5. (775 aa)
lrrc40Leucine-rich repeat-containing protein 40. (602 aa)
LOC100170560LOC100170560 protein. (798 aa)
lrrc8dLOC100145421 protein. (855 aa)
lrrc8cSTT3A, subunit of the oligosaccharyltransferase complex (catalytic). (806 aa)
eva1a-2Eva-1 homolog A. (711 aa)
AMIGO3Adhesion molecule with Ig like domain 3. (493 aa)
cyb5b-2Cytochrome b5 type B (outer mitochondrial membrane); Belongs to the Toll-like receptor family. (1024 aa)
Lrg1LRRCT domain-containing protein. (336 aa)
lrwd1Leucine-rich repeat and WD repeat-containing protein 1; Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post- replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability (By similarity); Belongs to the LRWD1 family. (691 aa)
lrrc69Uncharacterized protein. (345 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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