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| | PDE6B | Phosphodiesterase. (847 aa) |
| | ADCY1 | Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1118 aa) |
| | GUCY1B1 | Guanylate cyclase 1 soluble subunit beta 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (636 aa) |
| | LOC100489435 | Guanylate cyclase. (1103 aa) |
| | entpd5 | Uncharacterized protein; Belongs to the GDA1/CD39 NTPase family. (428 aa) |
| | nme3 | SRY-box 8; Belongs to the NDK family. (188 aa) |
| | urah | 5-hydroxyisourate hydrolase; Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily. (143 aa) |
| | nme2 | Nucleoside diphosphate kinase. (204 aa) |
| | nt5c2 | Cytosolic purine 5'-nucleotidase; May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5'-monophosphate (IMP) and other purine nucleotides (By similarity). (638 aa) |
| | ighv1-3 | DHHA2 domain-containing protein. (300 aa) |
| | ENSXETP00000005678 | Membrane associated ring-CH-type finger 9. (250 aa) |
| | pld1-2 | Phospholipase D1. (919 aa) |
| | pde9a | Chromosome 16 open reading frame 72; Belongs to the cyclic nucleotide phosphodiesterase family. (344 aa) |
| | pde4a | Phosphodiesterase. (690 aa) |
| | nt5c1a | Uncharacterized protein. (430 aa) |
| | ada.2 | A_deaminase domain-containing protein. (415 aa) |
| | impdh1 | Inosine-5'-monophosphate dehydrogenase 1; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (596 aa) |
| | GMPS | Guanine monophosphate synthase. (763 aa) |
| | guk1 | EF-hand calcium-binding domain 7. (233 aa) |
| | gucy1b2 | Ankyrin 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (615 aa) |
| | urad | Vascular endothelial growth factor A. (175 aa) |
| | entpd2 | Mitogen-activated protein kinase 8 interacting protein 2; Belongs to the GDA1/CD39 NTPase family. (484 aa) |
| | pklr | Pyruvate kinase; Belongs to the pyruvate kinase family. (460 aa) |
| | ak5 | Uncharacterized protein; Belongs to the adenylate kinase family. (557 aa) |
| | dck.1 | Dck protein. (265 aa) |
| | adsl | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (513 aa) |
| | nt5c3a | 5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (334 aa) |
| | pde6h | Uncharacterized protein. (113 aa) |
| | rrm2b | Uncharacterized protein. (416 aa) |
| | pde2a | Uncharacterized protein. (594 aa) |
| | enpp4 | Bis(5'-adenosyl)-triphosphatase enpp4; Hydrolyzes extracellular Ap3A into AMP and ADP, and Ap4A into AMP and ATP. Ap3A and Ap4A are diadenosine polyphosphates thought to induce proliferation of vascular smooth muscle cells. Acts as a procoagulant, mediating platelet aggregation at the site of nascent thrombus via release of ADP from Ap3A and activation of ADP receptors (By similarity); Belongs to the nucleotide pyrophosphatase/phosphodiesterase family. (452 aa) |
| | allc | Allantoicase; Utilization of purines as secondary nitrogen sources, when primary sources are limiting. (389 aa) |
| | DGUOK | Deoxyguanosine kinase. (265 aa) |
| | nudt5 | Nudix (Nucleoside diphosphate linked moiety x) type motif 5; Belongs to the Nudix hydrolase family. (221 aa) |
| | LOC100498474 | Uncharacterized protein. (264 aa) |
| | pde6g | LOC100124827 protein. (87 aa) |
| | adssl1 | Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. Belongs to the adenylosuccinate synthetase family. (468 aa) |
| | GUCY2F | Guanylate cyclase. (1133 aa) |
| | ampd3 | AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (782 aa) |
| | nt5c3b | 5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (290 aa) |
| | hexb-2 | Hexosaminidase B (beta polypeptide). (176 aa) |
| | pde7b | Phosphodiesterase. (506 aa) |
| | entpd3 | Progesterone receptor membrane component 1; Belongs to the GDA1/CD39 NTPase family. (510 aa) |
| | papss1 | 3'-phosphoadenosine 5'-phosphosulfate synthase 1. (624 aa) |
| | pfas | Glutamine amidotransferase type-1 domain-containing protein. (1351 aa) |
| | PRUNE1 | Prune exopolyphosphatase 1. (517 aa) |
| | NPR2 | Guanylate cyclase. (722 aa) |
| | uox | Uricase; Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin. Belongs to the uricase family. (304 aa) |
| | hddc3 | Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1; ppGpp hydrolyzing enzyme involved in starvation response. (179 aa) |
| | xdh | Phospholipid phosphatase related 2. (1329 aa) |
| | ADCY6 | Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1169 aa) |
| | ak2 | Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. (235 aa) |
| | pde5a | Phosphodiesterase. (943 aa) |
| | ppat | Amidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (540 aa) |
| | ADCY9 | Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1295 aa) |
| | paics.1 | AIRC domain-containing protein. (490 aa) |
| | NT5E | 5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family. (582 aa) |
| | nt5m | Potassium channel, voltage gated shaker related subfamily A, member 1. (227 aa) |
| | fhit | Bis(5'-adenosyl)-triphosphatase. (148 aa) |
| | ak1 | Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. (502 aa) |
| | pnp | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (297 aa) |
| | AMPD1 | AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (771 aa) |
| | adcy4 | Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1072 aa) |
| | ptrhd1 | Inactive serine protease PAMR1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (915 aa) |
| | ENTPD6 | Ectonucleoside triphosphate diphosphohydrolase 6; Belongs to the GDA1/CD39 NTPase family. (469 aa) |
| | aprt | Adenine phosphoribosyltransferase. (180 aa) |
| | cant1 | Calcium activated nucleotidase 1. (400 aa) |
| | pde4c | Phosphodiesterase. (801 aa) |
| | dck.2 | Dpy-19-like 4. (265 aa) |
| | PAPSS2 | 3'-phosphoadenosine 5'-phosphosulfate synthase 2. (656 aa) |
| | GUCY2C | Guanylate cyclase 2C. (1078 aa) |
| | LOC101734573 | Myocardial zonula adherens protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (132 aa) |
| | entpd8 | Forkhead box protein C2; Belongs to the GDA1/CD39 NTPase family. (478 aa) |
| | ampd2 | AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (831 aa) |
| | ITPA | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. (194 aa) |
| | gart | Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. (1016 aa) |
| | prps1 | Pribosyltran_N domain-containing protein. (322 aa) |
| | pde6a | Phosphodiesterase. (866 aa) |
| | gmpr2 | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (381 aa) |
| | nme6 | Nucleoside diphosphate kinase 6; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (179 aa) |
| | adcy7 | Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1061 aa) |
| | prps2 | Ribose-phosphate pyrophosphokinase 2; Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis; Belongs to the ribose-phosphate pyrophosphokinase family. (318 aa) |
| | entpd1 | NEDD4 binding protein 2-like 1; Belongs to the GDA1/CD39 NTPase family. (536 aa) |
| | nudt16 | Solute carrier family 45 member 2. (213 aa) |
| | PDE1C | Phosphodiesterase. (710 aa) |
| | ENSXETP00000041957 | Phosphodiesterase 9A; Belongs to the cyclic nucleotide phosphodiesterase family. (247 aa) |
| | rrm2.2 | Collagen, type VI, alpha 6. (447 aa) |
| | gucy1a2 | LOC100145454 protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (712 aa) |
| | rrm2.1 | Uncharacterized protein. (397 aa) |
| | pgm1 | BUD23, rRNA methyltransferase and ribosome maturation factor. (632 aa) |
| | impdh2 | Inosine-5'-monophosphate dehydrogenase 2; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (594 aa) |
| | pde6d | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta; Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide [...] (170 aa) |
| | ak6 | Adenylate kinase isoenzyme 6; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation; Belongs to the adenylate kinase family. AK6 subfamily. (171 aa) |
| | gucy2d | Guanylate cyclase. (1081 aa) |
| | PDE10A | Phosphodiesterase. (818 aa) |
| | NT5C1A | 5'-nucleotidase, cytosolic IA. (364 aa) |
| | pde6c | Phosphodiesterase. (868 aa) |
| | rrm1 | Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (786 aa) |
| | AK4 | Adenylate kinase 4, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity. (231 aa) |
| | pde1a | Phosphodiesterase. (541 aa) |
| | atic | MGS domain-containing protein. (607 aa) |
| | adprm.2 | Potassium channel tetramerization domain containing 7. (337 aa) |
| | adprm | Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase; Hydrolyzes ADP-ribose, IDP-ribose, CDP-glycerol, CDP-choline and CDP-ethanolamine, but not other non-reducing ADP-sugars or CDP- glucose. (348 aa) |
| | LOC100498039 | Protoporphyrinogen oxidase. (496 aa) |
| | ak7 | Adenylate kinase 7. (710 aa) |
| | pde4b | Phosphodiesterase. (733 aa) |
| | adss | Adenylosuccinate synthetase isozyme 2 A; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. (477 aa) |
| | entpd4 | Novel protein similar to cornifelin; Belongs to the GDA1/CD39 NTPase family. (621 aa) |
| | gmpr | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (363 aa) |
| | wnk3 | Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1213 aa) |
| | PDE4D | Phosphodiesterase. (719 aa) |
| | pde11a | Uncharacterized protein. (892 aa) |
| | adk | Transmembrane phosphoinositide 3-phosphatase and tensin homolog 2. (370 aa) |
| | PDE7A | Phosphodiesterase. (467 aa) |
| | ak3 | GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. (221 aa) |
