(55 nodes) Glutathione metabolism network (Xenopus tropicalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC101730710	Nuclear envelope integral membrane protein 1. (211 aa)
	ggct	Uncharacterized protein. (189 aa)
	LOC100498594	Uncharacterized protein; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (454 aa)
	oplah	Uncharacterized protein. (1376 aa)
	gstt1	Uncharacterized protein; Belongs to the GST superfamily. (242 aa)
	lap3	Cytosol aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides (By similarity). Belongs to the peptidase M17 family. (521 aa)
	gsto2	Novel glutathione S-transferase omega protein. (241 aa)
	gpx3	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (157 aa)
	ggt1	Uncharacterized protein. (601 aa)
	LOC100498331	Uncharacterized protein; Belongs to the GST superfamily. (267 aa)
	ggt6	Pinin, desmosome associated protein. (360 aa)
	mgst1	DnaJ heat shock protein family (Hsp40) member B9. (90 aa)
	srm	Huntingtin interacting protein K; Belongs to the spermidine/spermine synthase family. (313 aa)
	PGD	6-phosphogluconate dehydrogenase, decarboxylating; Belongs to the 6-phosphogluconate dehydrogenase family. (552 aa)
	gpx7	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (190 aa)
	rrm2b	Uncharacterized protein. (416 aa)
	TXNDC12	Thioredoxin domain containing 12. (169 aa)
	gsr	Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (590 aa)
	LOC100493771	Uncharacterized protein. (595 aa)
	gss	Glutathione synthetase. (506 aa)
	nat8.9	N-acetyltransferase domain-containing protein. (220 aa)
	nat8.8	Eukaryotic translation initiation factor 4E nuclear import factor 1. (220 aa)
	nat8.7	ISL LIM homeobox 1. (286 aa)
	nat8.6	Pancreatic lipase-related protein 2. (219 aa)
	nat8.5	Integrin subunit alpha 1. (219 aa)
	nat8.4	Probable N-acetyltransferase camello; Plays a role in regulation of gastrulation, possibly by controlled reduction of cell adhesion in the periblastopore region which is necessary for optimal cell motility. Belongs to the camello family. (219 aa)
	sowaha	Sosondowah ankyrin repeat domain family member A. (218 aa)
	nat8.1	LOC100124951 protein. (221 aa)
	veph1	Cleavage stimulation factor, 3' pre-RNA, subunit 2; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (467 aa)
	azin2	Sodium-dependent phosphate transporter 2; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (458 aa)
	LOC734071	Posterior protein 2. (116 aa)
	gstt1-2	Apoptosis enhancing nuclease; Belongs to the GST superfamily. (244 aa)
	idh1	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (482 aa)
	gsto1	Sushi-repeat containing protein X-linked 2; Belongs to the GST superfamily. (275 aa)
	mgst3	Single immunoglobulin and toll-interleukin 1 receptor (TIR) domain. (147 aa)
	gstp1	Gonadotropin releasing hormone receptor. (234 aa)
	prdx6	Peroxiredoxin 6. (224 aa)
	chac2	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family. (184 aa)
	gpx8	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (209 aa)
	LOC100127860	Fc fragment of IgE, low affinity II, receptor for (CD23). (147 aa)
	mgst2	Uncharacterized protein. (149 aa)
	hpgds	Prostaglandin D2 synthase 2, hematopoietic (Ptgds2); Belongs to the GST superfamily. (194 aa)
	rrm2.2	Collagen, type VI, alpha 6. (447 aa)
	rrm2.1	Uncharacterized protein. (397 aa)
	odc1	Dymeclin; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (464 aa)
	LOC100496158	Glutathione S-transferase. (247 aa)
	gsta4	Glutathione S-transferase A4. (233 aa)
	gclc	Glutamate-cysteine ligase, catalytic subunit. (637 aa)
	idh2	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (483 aa)
	g6pd	Glucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (655 aa)
	rrm1	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (786 aa)
	ANPEP	Aminopeptidase. (977 aa)
	sms	PABS domain-containing protein. (366 aa)
	gpx1	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (143 aa)
	gclm	Glutamate-cysteine ligase, modifier subunit. (274 aa)

Your Current Organism:

Xenopus tropicalis

NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANPEP	LOC100493771	ENSXETP00000047311	ENSXETP00000021687	Aminopeptidase.	Uncharacterized protein.	0.924
ANPEP	chac2	ENSXETP00000047311	ENSXETP00000036248	Aminopeptidase.	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	0.900
ANPEP	gclc	ENSXETP00000047311	ENSXETP00000044079	Aminopeptidase.	Glutamate-cysteine ligase, catalytic subunit.	0.929
ANPEP	gclm	ENSXETP00000047311	ENSXETP00000050659	Aminopeptidase.	Glutamate-cysteine ligase, modifier subunit.	0.920
ANPEP	ggct	ENSXETP00000047311	ENSXETP00000003999	Aminopeptidase.	Uncharacterized protein.	0.900
ANPEP	ggt1	ENSXETP00000047311	ENSXETP00000009368	Aminopeptidase.	Uncharacterized protein.	0.930
ANPEP	ggt6	ENSXETP00000047311	ENSXETP00000011472	Aminopeptidase.	Pinin, desmosome associated protein.	0.935
ANPEP	gss	ENSXETP00000047311	ENSXETP00000023444	Aminopeptidase.	Glutathione synthetase.	0.917
ANPEP	lap3	ENSXETP00000047311	ENSXETP00000008235	Aminopeptidase.	Cytosol aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides (By similarity). Belongs to the peptidase M17 family.	0.923
ANPEP	nat8.1	ENSXETP00000047311	ENSXETP00000024869	Aminopeptidase.	LOC100124951 protein.	0.900
ANPEP	nat8.4	ENSXETP00000047311	ENSXETP00000024846	Aminopeptidase.	Probable N-acetyltransferase camello; Plays a role in regulation of gastrulation, possibly by controlled reduction of cell adhesion in the periblastopore region which is necessary for optimal cell motility. Belongs to the camello family.	0.900
ANPEP	nat8.5	ENSXETP00000047311	ENSXETP00000024837	Aminopeptidase.	Integrin subunit alpha 1.	0.900
ANPEP	nat8.6	ENSXETP00000047311	ENSXETP00000024821	Aminopeptidase.	Pancreatic lipase-related protein 2.	0.900
ANPEP	nat8.7	ENSXETP00000047311	ENSXETP00000024807	Aminopeptidase.	ISL LIM homeobox 1.	0.900
ANPEP	nat8.8	ENSXETP00000047311	ENSXETP00000024800	Aminopeptidase.	Eukaryotic translation initiation factor 4E nuclear import factor 1.	0.900
ANPEP	nat8.9	ENSXETP00000047311	ENSXETP00000024796	Aminopeptidase.	N-acetyltransferase domain-containing protein.	0.900
ANPEP	sowaha	ENSXETP00000047311	ENSXETP00000024857	Aminopeptidase.	Sosondowah ankyrin repeat domain family member A.	0.900
LOC100127860	LOC100493771	ENSXETP00000037319	ENSXETP00000021687	Fc fragment of IgE, low affinity II, receptor for (CD23).	Uncharacterized protein.	0.650
LOC100127860	LOC100496158	ENSXETP00000037319	ENSXETP00000043410	Fc fragment of IgE, low affinity II, receptor for (CD23).	Glutathione S-transferase.	0.680
LOC100127860	LOC100498331	ENSXETP00000037319	ENSXETP00000010064	Fc fragment of IgE, low affinity II, receptor for (CD23).	Uncharacterized protein; Belongs to the GST superfamily.	0.693

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