STRINGSTRING
DGKH DGKH pip5k1a pip5k1a calm2 calm2 MTMR7 MTMR7 pip4p1 pip4p1 adamts2 adamts2 cdipt cdipt pik3cb pik3cb dgkk dgkk MTMR4 MTMR4 pik3r2 pik3r2 pi4k2a pi4k2a cds1 cds1 pten pten prkca prkca mtmr14 mtmr14 pik3c3 pik3c3 PIK3R1 PIK3R1 DGKQ DGKQ pi4ka pi4ka ocrl ocrl synj2 synj2 pip4k2c pip4k2c PPIP5K1 PPIP5K1 plcb4 plcb4 ITPKB ITPKB ippk ippk sacm1l sacm1l prkcg prkcg itpkc itpkc synj1 synj1 LOC100144987 LOC100144987 mtmr6 mtmr6 MTMR3 MTMR3 dgke dgke IPMK IPMK calml4 calml4 pikfyve pikfyve top1mt top1mt clpx-2 clpx-2 pi4k2b pi4k2b MTMR2 MTMR2 DGKZ DGKZ prkcb prkcb pik3c2a pik3c2a impa2 impa2 INPP4B INPP4B PIP5K1B PIP5K1B mtm1 mtm1 ip6k2 ip6k2 impad1 impad1 inpp5a.1 inpp5a.1 mtmr1 mtmr1 MTMR8 MTMR8 PLCG1 PLCG1 PPIP5K2 PPIP5K2 dgkd dgkd PLCG2 PLCG2 plcd1 plcd1 itpk1 itpk1 pik3ca pik3ca inpp4a inpp4a pip4k2a pip4k2a itpka itpka plcd4 plcd4 pip4k2b pip4k2b pik3r3 pik3r3 itpr3 itpr3 pip5k1c pip5k1c ip6k1 ip6k1 inpp5e inpp5e DGKA DGKA PLCB2 PLCB2 impa1 impa1 pip4p2 pip4p2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DGKHDiacylglycerol kinase. (1235 aa)
pip5k1aPIPK domain-containing protein. (468 aa)
calm2Calmodulin 1 (Phosphorylase kinase, delta); Belongs to the calmodulin family. (149 aa)
MTMR7Myotubularin related protein 7. (657 aa)
pip4p1Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (327 aa)
adamts2ADAM metallopeptidase with thrombospondin type 1 motif 2. (449 aa)
cdiptCDP-diacylglycerol--inositol 3-phosphatidyltransferase. (218 aa)
pik3cbSolute carrier family 27 member 6; Belongs to the PI3/PI4-kinase family. (1085 aa)
dgkkDiacylglycerol kinase. (1152 aa)
MTMR4Myotubularin related protein 4. (1093 aa)
pik3r2Uncharacterized protein. (719 aa)
pi4k2aPhosphatidylinositol 4-kinase type 2-alpha; Membrane-bound phosphatidylinositol-4 kinase (PI4-kinase) that catalyzes the phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P), a lipid that plays important roles in endocytosis, Golgi function, protein sorting and membrane trafficking. Besides, phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P) is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). (474 aa)
cds1Phosphatidate cytidylyltransferase; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin. (441 aa)
ptenPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (402 aa)
prkcaR3H domain and coiled-coil-containing 1-like; Belongs to the protein kinase superfamily. (261 aa)
mtmr14LOC100036693 protein. (626 aa)
pik3c3Phosphatidylinositol 3-kinase catalytic subunit type 3. (912 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (718 aa)
DGKQDiacylglycerol kinase. (956 aa)
pi4kaCordon-bleu WH2 repeat protein; Belongs to the PI3/PI4-kinase family. (2088 aa)
ocrlHairy and enhancer of split 5, gene 2. (909 aa)
synj2Scavenger receptor class B member 1. (1551 aa)
pip4k2cPhosphatidylinositol 5-phosphate 4-kinase type-2 gamma; May play an important role in the production of Phosphatidylinositol bisphosphate (PIP2). (484 aa)
PPIP5K1Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates [...] (1361 aa)
plcb41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1205 aa)
ITPKBKinase; Belongs to the inositol phosphokinase (IPK) family. (655 aa)
ippkInositol-pentakisphosphate 2-kinase; Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). (489 aa)
sacm1lSAC domain-containing protein. (586 aa)
prkcgProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (690 aa)
itpkcKinase; Belongs to the inositol phosphokinase (IPK) family. (518 aa)
synj1Stathmin 3. (1548 aa)
LOC100144987Inositol-tetrakisphosphate 1-kinase; Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Belongs to the ITPK1 family. (390 aa)
mtmr6Zinc finger protein 362. (727 aa)
MTMR3Myotubularin related protein 3. (1224 aa)
dgkeDiacylglycerol kinase. (568 aa)
IPMKKinase; Belongs to the inositol phosphokinase (IPK) family. (399 aa)
calml4Calmodulin-like protein 4; Belongs to the calmodulin family. (153 aa)
pikfyveUncharacterized protein. (2104 aa)
top1mtPhosphoinositide phospholipase C. (1368 aa)
clpx-2Caseinolytic mitochondrial matrix peptidase chaperone subunit. (525 aa)
pi4k2bPhosphatidylinositol 4-kinase type 2-beta; Contributes to the overall PI4-kinase activity of the cell. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5- bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3) (By similarity); Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily. (537 aa)
MTMR2Myotubularin related protein 2. (596 aa)
DGKZDiacylglycerol kinase. (1105 aa)
prkcbProtein kinase C beta type; Calcium-activated and phospholipid-dependent serine/threonine-protein kinase involved in various processes such as regulation of the B-cell receptor (BCR) signalosome, apoptosis and transcription regulation. Plays a key role in B-cell activation and function by regulating BCR-induced NF-kappa-B activation and B-cell survival. Required for recruitment and activation of the IKK kinase to lipid rafts and mediates phosphorylation of card11/carma1, leading to activate the NF-kappa-B signaling. Involved in apoptosis following oxidative damage: in case of oxidative [...] (671 aa)
pik3c2aUncharacterized protein; Belongs to the PI3/PI4-kinase family. (1714 aa)
impa2Inositol-1-monophosphatase. (309 aa)
INPP4BInositol polyphosphate-4-phosphatase type II B. (972 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type 1 beta. (585 aa)
mtm1Myotubularin; Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). (602 aa)
ip6k2Kinase; Belongs to the inositol phosphokinase (IPK) family. (429 aa)
impad1Inositol monophosphatase 3; Belongs to the inositol monophosphatase superfamily. (356 aa)
inpp5a.1Inositol polyphosphate-5-phosphatase, 40kDa. (432 aa)
mtmr1Myotubularin phosphatase domain-containing protein. (690 aa)
MTMR8Myotubularin related protein 8. (720 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1269 aa)
PPIP5K2Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates [...] (1257 aa)
dgkdDiacylglycerol kinase. (1221 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1256 aa)
plcd1Phosphoinositide phospholipase C. (786 aa)
itpk1Inositol-tetrakisphosphate 1-kinase; Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Belongs to the ITPK1 family. (396 aa)
pik3caPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1067 aa)
inpp4aUncharacterized protein. (972 aa)
pip4k2aChromosome 11 open reading frame 54. (470 aa)
itpkaKinase; Belongs to the inositol phosphokinase (IPK) family. (470 aa)
plcd4Phosphoinositide phospholipase C. (758 aa)
pip4k2bLaeverin. (426 aa)
pik3r3Phosphoinositide-3-kinase, regulatory subunit, polypeptide 3 (P55, gamma). (461 aa)
itpr3Inositol (1,4,5) trisphosphate receptor type 3. (2673 aa)
pip5k1cPIPK domain-containing protein. (688 aa)
ip6k1Kinase; Belongs to the inositol phosphokinase (IPK) family. (412 aa)
inpp5eMajor histocompatibility complex class I antigen. (607 aa)
DGKADiacylglycerol kinase. (771 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1250 aa)
impa1Inositol-1-monophosphatase. (280 aa)
pip4p2Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (276 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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