STRINGSTRING
cyth2 cyth2 rab3gap2-2 rab3gap2-2 ehd1 ehd1 rab11fip5 rab11fip5 rab7a rab7a arf3 arf3 pip5k1a pip5k1a LOC100216037 LOC100216037 washc1 washc1 iqsec3 iqsec3 pdcd6ip pdcd6ip vps28 vps28 grk1 grk1 pard6g pard6g IQSEC2 IQSEC2 rab11a rab11a vps26a vps26a arpc2 arpc2 ehd4 ehd4 washc3 washc3 rab8a rab8a arf6 arf6 GRK5 GRK5 ldlrap1 ldlrap1 EGFR EGFR grk3 grk3 smad2 smad2 ap2b1 ap2b1 il2rg il2rg rufy1 rufy1 git2 git2 vps36 vps36 arpc1a arpc1a vps25 vps25 arf5 arf5 arpc5l arpc5l vps35 vps35 rab11fip2 rab11fip2 rhoa.2 rhoa.2 LOC101735127 LOC101735127 arfgap1 arfgap1 wipf1 wipf1 hspa1b hspa1b DAB2 DAB2 vps45 vps45 ldlr ldlr MGC75872 MGC75872 tfrc-2 tfrc-2 nedd4 nedd4 hras hras AGAP2 AGAP2 cbl cbl HSPA2 HSPA2 asap2 asap2 vta1 vta1 rab35 rab35 snx5 snx5 epn2 epn2 smurf1 smurf1 smap1 smap1 washc2a washc2a washc4 washc4 chmp3-2 chmp3-2 tgfbr2 tgfbr2 kif5a kif5a ZFYVE9 ZFYVE9 grk7 grk7 sh3gl2 sh3gl2 pard3 pard3 ehd2 ehd2 ap2s1 ap2s1 epn3 epn3 vps4a vps4a spg21 spg21 src src spart spart dnm2 dnm2 cblb cblb hgs hgs vps37b vps37b arf11l arf11l IGF1R IGF1R chmp2b chmp2b ccr2 ccr2 asap3 asap3 stam2 stam2 WIPF3 WIPF3 SNX1 SNX1 cltcl1 cltcl1 chmp1a chmp1a wipf2 wipf2 eps15 eps15 cyth1 cyth1 vps26b vps26b chmp6 chmp6 hspa1a hspa1a PIP5KL1 PIP5KL1 LOC100135070 LOC100135070 arfgef2 arfgef2 rab11fip4l rab11fip4l ARFGEF1 ARFGEF1 snx12 snx12 VPS37D VPS37D acap3 acap3 mdm2 mdm2 grk4 grk4 rab31 rab31 LOC100127707 LOC100127707 ARRB1 ARRB1 ist1 ist1 arpc1b arpc1b cyth4 cyth4 vps4b vps4b rab35l rab35l folr1 folr1 pdgfra pdgfra RBSN RBSN smap2 smap2 eps15l1 eps15l1 prkcz prkcz grk6 grk6 LOC100488540 LOC100488540 rtbdn rtbdn DNM3 DNM3 snx3 snx3 arpc5 arpc5 cdc42 cdc42 cblc cblc traf6 traf6 sh3gl3 sh3gl3 vps29 vps29 arpc3 arpc3 rab11b.2 rab11b.2 PIP5K1B PIP5K1B SNX2 SNX2 pard6b pard6b tgfbr1 tgfbr1 sh3glb2 sh3glb2 cyth3 cyth3 ei24-2 ei24-2 slc4a9 slc4a9 LOC100496423 LOC100496423 cav3.2 cav3.2 gbf1 gbf1 rab5d rab5d rnf41 rnf41 fgfr4 fgfr4 kif5c kif5c kif5b kif5b rhoa rhoa chmp7 chmp7 chmp1b chmp1b chmp2a chmp2a arf1 arf1 Acap1 Acap1 RAB11FIP1 RAB11FIP1 prkci prkci IGF2R IGF2R slc25a53 slc25a53 gstp1-2 gstp1-2 zfyve16 zfyve16 chmp5 chmp5 cltc cltc itch itch cav3.1 cav3.1 chmp4b chmp4b hspa8 hspa8 cxcr4 cxcr4 eea1 eea1 capza1 capza1 rhoc rhoc mvb12a mvb12a cav2 cav2 cav1 cav1 capza2 capza2 fgfr3 fgfr3 stambp stambp arf4 arf4 rab5a rab5a snf8 snf8 snx6 snx6 agap1 agap1 amph amph psd4 psd4 wasl wasl pip5k1c pip5k1c izumo1r izumo1r stam stam sh3gl1 sh3gl1 rab5b rab5b washc5 washc5 USP8 USP8 CHMP4C CHMP4C wwp1 wwp1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
cyth2Uncharacterized protein. (408 aa)
rab3gap2-2F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (219 aa)
ehd1Nuclear factor, erythroid 2 like 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (534 aa)
rab11fip5Uncharacterized protein. (1534 aa)
rab7aRAB7A, member RAS oncogene family. (207 aa)
arf3LOC100145191 protein; Belongs to the small GTPase superfamily. Arf family. (181 aa)
pip5k1aPIPK domain-containing protein. (468 aa)
LOC100216037Uncharacterized protein. (342 aa)
washc1WASH complex subunit 1; Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. Its assembly in the WASH core complex seems to inhibit its NPF activity and is required for its membrane targeting; Belongs to the WASH1 family. (472 aa)
iqsec3SEC7 domain-containing protein. (1109 aa)
pdcd6ipBRO1 domain-containing protein. (874 aa)
vps28Vacuolar protein sorting-associated protein 28 homolog; Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process. (247 aa)
grk1G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (559 aa)
pard6gPar-6 partitioning defective 6 homolog gamma (C. elegans). (384 aa)
IQSEC2IQ motif and Sec7 domain 2. (1364 aa)
rab11aRAB11A, member RAS oncogene family. (216 aa)
vps26aVacuolar protein sorting-associated protein 26A; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. Retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) (By similarity). (329 aa)
arpc2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (299 aa)
ehd4Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (537 aa)
washc3DEAH-box helicase 33. (199 aa)
rab8aChloride channel, voltage-sensitive 7. (220 aa)
arf6Solute carrier family 8 (sodium/calcium exchanger), member 1; Belongs to the small GTPase superfamily. Arf family. (229 aa)
GRK5G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (590 aa)
ldlrap1Zinc finger protein 238, gene 2. (309 aa)
EGFRReceptor protein-tyrosine kinase. (1216 aa)
grk3G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (707 aa)
smad2Mothers against decapentaplegic homolog. (467 aa)
ap2b1AP complex subunit beta. (970 aa)
il2rgFibronectin type-III domain-containing protein. (329 aa)
rufy1Family with sequence similarity 43 member B. (606 aa)
git2Uncharacterized protein. (728 aa)
vps36Vacuolar protein sorting 36 (Yeast). (387 aa)
arpc1aActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (381 aa)
vps25Sialic acid binding Ig-like lectin 10. (174 aa)
arf5Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (181 aa)
arpc5lActin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (152 aa)
vps35Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (796 aa)
rab11fip2LOC100127577 protein. (518 aa)
rhoa.2Nuclear receptor binding SET domain protein 3. (193 aa)
LOC101735127Monoacylglycerol O-acyltransferase 2, gene 2. (330 aa)
arfgap1Transmembrane protein 200A. (305 aa)
wipf1Uncharacterized protein. (446 aa)
hspa1bUncharacterized protein; Belongs to the heat shock protein 70 family. (639 aa)
DAB2DAB adaptor protein 2. (820 aa)
vps45Vacuolar protein sorting 45A; Belongs to the STXBP/unc-18/SEC1 family. (570 aa)
ldlrPhosphatidylinositol glycan anchor biosynthesis class S. (938 aa)
MGC75872Uncharacterized protein. (199 aa)
tfrc-2Uncharacterized protein. (748 aa)
nedd4E3 ubiquitin-protein ligase. (896 aa)
hrasChloride channel accessory 1 gene 1. (217 aa)
AGAP2ArfGAP with GTPase domain, ankyrin repeat and PH domain 2. (2037 aa)
cblUncharacterized protein. (954 aa)
HSPA2Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (643 aa)
asap2IKAROS family zinc finger 2. (1025 aa)
vta1Transient receptor potential cation channel, subfamily M, member 4. (281 aa)
rab35RAB35, member RAS oncogene family. (201 aa)
snx5Sorting nexin; Involved in several stages of intracellular trafficking. (406 aa)
epn2ENTH domain-containing protein. (586 aa)
smurf1E3 ubiquitin-protein ligase. (748 aa)
smap1AMMECR1 like. (471 aa)
washc2aCAP-ZIP_m domain-containing protein. (1037 aa)
washc4Matrix metallopeptidase 24. (1174 aa)
chmp3-2Charged multivesicular body protein 3; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Involved in late stages of cytokinesis. Plays a role in en [...] (220 aa)
tgfbr2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (728 aa)
kif5aZinc finger protein 451; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1033 aa)
ZFYVE9Zinc finger FYVE domain-containing protein. (1320 aa)
grk7G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (551 aa)
sh3gl2Uncharacterized protein. (350 aa)
pard3Potassium channel, voltage-gated shaker-related subfamily A, member 5. (1377 aa)
ehd2MGC107790 protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (538 aa)
ap2s1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (157 aa)
epn3Acyl-CoA dehydrogenase short chain. (603 aa)
vps4aUncharacterized protein; Belongs to the AAA ATPase family. (462 aa)
spg21Serum/glucocorticoid-regulated kinase 2. (314 aa)
srcTyrosine-protein kinase. (557 aa)
spartMIT domain-containing protein. (592 aa)
dnm2Discoidin, CUB and LCCL domain containing 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (881 aa)
cblbE3 ubiquitin-protein ligase CBL-B; E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. (982 aa)
hgsImmunoglobulin heavy chain precursor. (792 aa)
vps37bVacuolar protein sorting 37 homolog B. (287 aa)
arf11lDDB1 and CUL4 associated factor 7; Belongs to the small GTPase superfamily. Arf family. (188 aa)
IGF1RTyrosine-protein kinase receptor. (1362 aa)
chmp2bCharged multivesicular body protein 2b; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids (By similarity). (225 aa)
ccr21-acylglycerol-3-phosphate O-acyltransferase 1; Belongs to the G-protein coupled receptor 1 family. (353 aa)
asap3Uncharacterized protein. (667 aa)
stam2Interferon-induced transmembrane protein 10. (522 aa)
WIPF3WAS/WASL interacting protein family member 3. (424 aa)
SNX1Sorting nexin 1. (581 aa)
cltcl1Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1693 aa)
chmp1aSignal peptide, CUB domain, EGF-like 2. (196 aa)
wipf2WH2 domain-containing protein. (426 aa)
eps15Protein arginine N-methyltransferase 6. (970 aa)
cyth1Uncharacterized protein. (406 aa)
vps26bVacuolar protein sorting-associated protein 26B; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. Retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) (By similarity). (338 aa)
chmp6LOC100125185 protein. (200 aa)
hspa1aUncharacterized protein; Belongs to the heat shock protein 70 family. (648 aa)
PIP5KL1Phosphatidylinositol-4-phosphate 5-kinase like 1. (477 aa)
LOC100135070SH3-domain-binding protein 2. (309 aa)
arfgef2Dopamine receptor D2. (1792 aa)
rab11fip4lTubulin epsilon 1. (406 aa)
ARFGEF1ADP ribosylation factor guanine nucleotide exchange factor 1. (1856 aa)
snx12PX domain-containing protein. (237 aa)
VPS37DVPS37D subunit of ESCRT-I. (238 aa)
acap3Folliculin interacting protein 1. (871 aa)
mdm2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (497 aa)
grk4G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (578 aa)
rab31Non-SMC condensin I complex subunit D2. (206 aa)
LOC100127707Ig-like domain-containing protein; Belongs to the MHC class I family. (308 aa)
ARRB1Arrestin beta 1. (434 aa)
ist1Uncharacterized protein. (359 aa)
arpc1bActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (383 aa)
cyth4Splicing factor 3b subunit 4. (322 aa)
vps4bUncharacterized protein; Belongs to the AAA ATPase family. (501 aa)
rab35lUncharacterized protein. (201 aa)
folr1Folate_rec domain-containing protein. (292 aa)
pdgfraPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1096 aa)
RBSNRabenosyn, RAB effector. (817 aa)
smap2Forkhead box protein N3. (421 aa)
eps15l1Uncharacterized protein. (918 aa)
prkczProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (593 aa)
grk6G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (575 aa)
LOC100488540Actin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (357 aa)
rtbdnProtein kinase C eta. (241 aa)
DNM3Dynamin 3. (310 aa)
snx3Sorting nexin 12. (162 aa)
arpc5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (150 aa)
cdc42Uncharacterized protein. (212 aa)
cblcUncharacterized protein. (425 aa)
traf6TNF receptor-associated factor 6; E3 ubiquitin-protein ligase that mediates ubiquitination of proteins. Adapter protein that seems to play a role in signal transduction. (558 aa)
sh3gl3GIPC PDZ domain containing family member 2. (384 aa)
vps29Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. Retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) (By similarity). Acts also as component of the retriever complex. The retriever complex is an heterotrimeric complex related to retromer cargo-selective com [...] (182 aa)
arpc3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (181 aa)
rab11b.2Human immunodeficiency virus type I enhancer binding protein 3. (218 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type 1 beta. (585 aa)
SNX2Sorting nexin 2. (523 aa)
pard6bUncharacterized protein. (377 aa)
tgfbr1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa)
sh3glb2Uncharacterized protein. (399 aa)
cyth3Olfactory receptor family 52 subfamily D member 1. (411 aa)
ei24-2Etoposide induced 2.4; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (879 aa)
slc4a9SEC7 domain-containing protein. (160 aa)
LOC100496423Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (164 aa)
cav3.2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (153 aa)
gbf1Olfactory receptor class II (xb178 gene). (1854 aa)
rab5dRAB5B, member RAS oncogene family. (213 aa)
rnf41Bardet-Biedl syndrome 5. (317 aa)
fgfr4Fibroblast growth factor receptor. (833 aa)
kif5cKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (959 aa)
kif5bKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (962 aa)
rhoaRas homolog gene family, member A. (193 aa)
chmp7Charged multivesicular body protein 7; ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope during late anaphase. Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase. Plays a role in the endosomal sorting pathway; Belongs to the SNF7 family. (469 aa)
chmp1bCharged multivesicular body protein 1b; Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids; Belongs to the SNF7 family. (211 aa)
chmp2aCharged multivesicular body protein 2a; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids (By similarity). (220 aa)
arf1Fibroblast growth factor (acidic) intracellular binding protein; Belongs to the small GTPase superfamily. Arf family. (181 aa)
Acap1Uncharacterized protein. (433 aa)
RAB11FIP1RAB11 family interacting protein 1. (1056 aa)
prkciProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (588 aa)
IGF2RInsulin like growth factor 2 receptor. (2400 aa)
slc25a53Solute carrier family 25 member 53; Belongs to the MHC class I family. (307 aa)
gstp1-2Ig-like domain-containing protein; Belongs to the MHC class I family. (301 aa)
zfyve16Zinc finger FYVE domain-containing protein. (1443 aa)
chmp5Charged multivesicular body protein 5; Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids (By similarity). (240 aa)
cltcClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1692 aa)
itchE3 ubiquitin-protein ligase. (853 aa)
cav3.1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (155 aa)
chmp4bCharged multivesicular body protein 4b; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids (By similarity). (222 aa)
hspa8WD repeat-containing protein 26; Belongs to the heat shock protein 70 family. (654 aa)
cxcr4C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine cxcl12/sdf-1. Transduces a signal by increasing the intracellular calcium ion level. Signaling with cxcl12/sdf-1 mediates the directional movement of mesodermal cells during gastrulation. May play a role in the migration of embryonic presumptive primordial germ cells (pPGCs). May also be involved in regulating migration of hematopoietic stem cells into the larval liver (By similarity). (358 aa)
eea1Ovo like zinc finger 1. (1412 aa)
capza1F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (286 aa)
rhocCalponin 3, acidic. (193 aa)
mvb12aUncharacterized protein. (418 aa)
cav2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (160 aa)
cav1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (180 aa)
capza2F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (295 aa)
fgfr3Fibroblast growth factor receptor. (829 aa)
stambpSTAM-binding protein. (416 aa)
arf4ADP-ribosylation factor 4; Belongs to the small GTPase superfamily. Arf family. (180 aa)
rab5aRAB5A, member RAS oncogene family. (216 aa)
snf8Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex (By similarity). (257 aa)
snx6Sorting nexin; Involved in several stages of intracellular trafficking. (407 aa)
agap1Stathmin 4. (1203 aa)
amphUncharacterized protein. (671 aa)
psd4Uncharacterized protein. (478 aa)
waslWiskott-Aldrich syndrome-like. (511 aa)
pip5k1cPIPK domain-containing protein. (688 aa)
izumo1rLOC100135193 protein. (233 aa)
stamADAM metallopeptidase with thrombospondin type 1 motif 8. (541 aa)
sh3gl1SH3-domain GRB2-like 1. (366 aa)
rab5bRAB5B, member RAS oncogene family. (215 aa)
washc5WASH complex subunit 5; Acts at least in part as component of the WASH complex which seems to regulate washc1 nucleation-promoting factor (NPF) activity and is required for its membrane targeting during endosomal sorting. (1159 aa)
USP8Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family. (1058 aa)
CHMP4CCharged multivesicular body protein 4C. (222 aa)
wwp1E3 ubiquitin-protein ligase. (914 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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