STRINGSTRING
COX1 COX1 COX2 COX2 COX3 COX3 CYTB CYTB cox6a1 cox6a1 SLC8A2 SLC8A2 atp1a3 atp1a3 cacnb3 cacnb3 cacng6 cacng6 atp2a3 atp2a3 slc9a7 slc9a7 atp1a2 atp1a2 UQCRB UQCRB myl4 myl4 cox6c cox6c cacng2 cacng2 tnnt2 tnnt2 LOC100485637 LOC100485637 myh6 myh6 cox7c cox7c cacng3 cacng3 uqcrfs1 uqcrfs1 tnni3 tnni3 cox6a2 cox6a2 myl2 myl2 acta4 acta4 LOC100127850 LOC100127850 uqcr11 uqcr11 ATP1B4 ATP1B4 CACNA2D2 CACNA2D2 atp2a1 atp2a1 atp1b3 atp1b3 atp1a1 atp1a1 MGC75582 MGC75582 cox7a2 cox7a2 cox7a2l cox7a2l cox7b cox7b uqcrq uqcrq cacnb4 cacnb4 cox7a1 cox7a1 cacng8 cacng8 cacng7 cacng7 atp1b1 atp1b1 tpm4 tpm4 fxyd2 fxyd2 cox6b1 cox6b1 uqcr10 uqcr10 SLC8A1 SLC8A1 cox5a cox5a myl3 myl3 slc9a1 slc9a1 LOC100127750 LOC100127750 cacng1 cacng1 fes fes cox5b.1 cox5b.1 LOC100487899 LOC100487899 ATP2A2 ATP2A2 SLC8A3 SLC8A3 tnnc1 tnnc1 atp1b2 atp1b2 cox4i1 cox4i1 CACNA1C CACNA1C cox5b.2 cox5b.2 acta1 acta1 SLC9A6 SLC9A6 tpm1 tpm1 CACNB2 CACNB2 actc1 actc1 cacna2d1 cacna2d1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
COX1Cytochrome c oxidase subunit 1; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B. (518 aa)
COX2Cytochrome c oxidase subunit 2; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1. (229 aa)
COX3Cytochrome c oxidase subunit 3; Subunits I, II and III form the functional core of the enzyme complex. (261 aa)
CYTBCytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis. (380 aa)
cox6a1Cytochrome c oxidase subunit 6A, mitochondrial. (112 aa)
SLC8A2Solute carrier family 8 member A2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (914 aa)
atp1a3Nuclear apoptosis inducing factor 1; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (1113 aa)
cacnb3GuKc domain-containing protein. (490 aa)
cacng6Collagen, type IX, alpha 2. (146 aa)
atp2a3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1037 aa)
slc9a7Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (710 aa)
atp1a2Sodium/potassium-transporting ATPase subunit alpha. (1020 aa)
UQCRBCytochrome b-c1 complex subunit 7; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain; Belongs to the UQCRB/QCR7 family. (111 aa)
myl44-aminobutyrate aminotransferase. (190 aa)
cox6cCytochrome c oxidase subunit VIc. (79 aa)
cacng2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (321 aa)
tnnt2Plexin A4. (259 aa)
LOC100485637Glypican 6; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1976 aa)
myh6D-tyrosyl-tRNA deacylase 2 (putative); Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1953 aa)
cox7cNipsnap homolog 1. (118 aa)
cacng3EH domain containing 4. (317 aa)
uqcrfs1Cytochrome b-c1 complex subunit Rieske, mitochondrial; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. (273 aa)
tnni3Transmembrane protein 256. (245 aa)
cox6a2Cytochrome c oxidase subunit 6A, mitochondrial. (105 aa)
myl2Adaptor related protein complex 5 subunit zeta 1. (245 aa)
acta4Actin, alpha sarcomeric/skeletal; Actins are highly conserved proteins that are involved in various types of cell motility; Belongs to the actin family. (390 aa)
LOC100127850Cytochrome c oxidase subunit VIIa polypeptide 2 like (Prov). (118 aa)
uqcr11Uncharacterized protein. (56 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (317 aa)
CACNA2D2Calcium voltage-gated channel auxiliary subunit alpha2delta 2. (1109 aa)
atp2a1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1052 aa)
atp1b3Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (279 aa)
atp1a1RAB8B, member RAS oncogene family; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (1190 aa)
MGC75582Actin, alpha cardiac muscle 2; Actins are highly conserved proteins that are involved in various types of cell motility. (377 aa)
cox7a2Intraflagellar transport 52. (83 aa)
cox7a2lUncharacterized protein. (175 aa)
cox7bMaternal embryonic leucine zipper kinase. (79 aa)
uqcrqUncharacterized protein. (82 aa)
cacnb4SH3 domain-containing protein. (550 aa)
cox7a1Uncharacterized protein. (82 aa)
cacng8Voltage-dependent calcium channel gamma-8 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (353 aa)
cacng7Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (275 aa)
atp1b1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (304 aa)
tpm4Guanylate cyclase 2D, membrane (retina-specific); Belongs to the tropomyosin family. (284 aa)
fxyd2FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (95 aa)
cox6b1Cytochrome c oxidase subunit; This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. (86 aa)
uqcr10Ubiquinol-cytochrome c reductase complex (7.2 kD) (Ucrc). (62 aa)
SLC8A1Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (964 aa)
cox5aCytochrome c oxidase, subunit Va. (148 aa)
myl3Myosin, light chain 3, alkali ventricular, skeletal, slow. (188 aa)
slc9a1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (792 aa)
LOC100127750Mastermind like transcriptional coactivator 1. (180 aa)
cacng1Voltage-dependent calcium channel gamma-1 subunit; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics. (148 aa)
fesVoltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (305 aa)
cox5b.1ADAM metallopeptidase with thrombospondin type 1 motif 1. (126 aa)
LOC100487899Cysteine-rich secretory protein LCCL domain-containing 2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (891 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1053 aa)
SLC8A3Solute carrier family 8 member A3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (923 aa)
tnnc1CTD small phosphatase like. (161 aa)
atp1b2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (306 aa)
cox4i1Cytochrome c oxidase subunit IV isoform 1. (169 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2150 aa)
cox5b.2Novel protein similar to cytochrome c oxidase subunit Vb. (131 aa)
acta1Actin, alpha 1, skeletal muscle. (377 aa)
SLC9A6Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (707 aa)
tpm1Uncharacterized protein; Belongs to the tropomyosin family. (333 aa)
CACNB2Calcium voltage-gated channel auxiliary subunit beta 2. (646 aa)
actc1Actin, alpha cardiac muscle 1, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility; Belongs to the actin family. (377 aa)
cacna2d1LOC100036724 protein. (1076 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.