STRINGSTRING
hes5.4 hes5.4 dvl3 dvl3 ep300 ep300 dtx1 dtx1 hes4 hes4 hey2 hey2 aqp11-2 aqp11-2 LOC101731574 LOC101731574 psen1 psen1 numb numb notch2 notch2 hes1 hes1 dtx3 dtx3 hes5.10 hes5.10 hes5.9 hes5.9 heatr6 heatr6 hes5.7 hes5.7 hes5.5 hes5.5 hes5.3 hes5.3 jag1 jag1 dlc dlc hdac2 hdac2 psen2 psen2 rfng rfng lfng lfng NUMBL NUMBL dtx2 dtx2 dtx3-2 dtx3-2 psenen psenen ovos2-3 ovos2-3 ncor2 ncor2 dll1 dll1 dvl1 dvl1 atxn1l atxn1l CIR1 CIR1 LOC101733898 LOC101733898 MAML3 MAML3 maml1 maml1 adam17 adam17 CTBP2 CTBP2 snw1 snw1 aph1a aph1a Notch4 Notch4 ctbp2l ctbp2l atxn1 atxn1 ctbp1 ctbp1 KAT2B KAT2B notch1 notch1 NOTCH3 NOTCH3 hdac1 hdac1 DLL4 DLL4 hey1 hey1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
hes5.4Uncharacterized protein. (159 aa)
dvl3Segment polarity protein dishevelled homolog DVL-3; Involved in the signal transduction pathway mediated by multiple Wnt genes (By similarity). Required during ciliogenesis for the docking of basal bodies to the apical plasma membrane (By similarity); Belongs to the DSH family. (713 aa)
ep300Suv3 like RNA helicase. (2493 aa)
dtx1Rhomboid domain containing 2. (623 aa)
hes4Transcription factor HES-4; Transcriptional repressor. Binds DNA on N-box motifs: 5'- CACNAG-3'. Promotes floor plate development and prechordal plate development. Required for lens development as early as the stage of lens field formation, partly through regulation of gene expression of the cell cycle inhibitor cdknx/p27(xic1). Required for formation of the neural crest downstream of multiple signaling pathways, and acts at the neural plate border via both DNA-binding dependent and independent mechanisms. Also acts via repressor-dependent and repressor-independent mechanisms in early [...] (281 aa)
hey2ST3 beta-galactoside alpha-2,3-sialyltransferase 1. (335 aa)
aqp11-2Aquaporin 11. (994 aa)
LOC101731574Bromo domain-containing protein. (84 aa)
psen1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (464 aa)
numbPID domain-containing protein. (654 aa)
notch2FTO alpha-ketoglutarate dependent dioxygenase. (2455 aa)
hes1Transcription factor HES-1; Transcriptional repressor of a subset of early mesodermal genes including myod1 and t/bra. Binds DNA on N-box motifs: 5'-CACNAG- 3'. Acts as a negative regulator of myogenesis, mediating Notch signaling to repress expression of myod1 (By similarity). (267 aa)
dtx3Dtx3 protein. (353 aa)
hes5.10Similar to hes5 (Hairy and enhancer of split 5 (Drosophila)). (166 aa)
hes5.9LOC733709 protein. (155 aa)
heatr6BHLH domain-containing protein. (85 aa)
hes5.7Growth arrest specific 2. (150 aa)
hes5.5BHLH domain-containing protein. (263 aa)
hes5.3Uncharacterized protein. (160 aa)
jag1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
dlcDelta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (642 aa)
hdac2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
psen2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (451 aa)
rfngBeta-1,3-N-acetylglucosaminyltransferase. (364 aa)
lfngBeta-1,3-N-acetylglucosaminyltransferase. (372 aa)
NUMBLNUMB like endocytic adaptor protein. (607 aa)
dtx2HECT and RLD domain containing E3 ubiquitin protein ligase family member 1. (592 aa)
dtx3-2Advillin. (212 aa)
psenenPresenilin enhancer 2 homolog (C. elegans). (101 aa)
ovos2-3Alpha-2-macroglobulin like 1 pseudogene. (2368 aa)
ncor2EPH receptor A4. (2455 aa)
dll1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (740 aa)
dvl1Uncharacterized protein. (707 aa)
atxn1lBICD family-like cargo adapter 2. (698 aa)
CIR1Corepressor interacting with RBPJ, 1. (559 aa)
LOC101733898Uncharacterized protein. (189 aa)
MAML3Mastermind like transcriptional coactivator 3. (1088 aa)
maml1Protein phosphatase methylesterase 1. (1030 aa)
adam17Monooxygenase, DBH-like 2, pseudogene. (834 aa)
CTBP2C-terminal binding protein 2. (1010 aa)
snw1Kelch repeat and BTB domain-containing protein 8. (549 aa)
aph1aRegulator of G-protein signaling 9-binding protein B. (247 aa)
Notch4ANK_REP_REGION domain-containing protein. (168 aa)
ctbp2lMitogen-activated protein kinase kinase kinase 10; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (481 aa)
atxn1Polymerase (RNA) II subunit H. (792 aa)
ctbp1Leucine zipper, putative tumor suppressor family member 3; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (482 aa)
KAT2BHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (806 aa)
notch1Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] (2535 aa)
NOTCH3Notch receptor 3. (2413 aa)
hdac1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (486 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (679 aa)
hey1Hairy/enhancer-of-split related with YRPW motif protein 1; Downstream effector of Notch signaling. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Acts as a suppressor of neurogenesis by antagonizing proneural gene function. Functions during floorplate development. Plays a role in pronephros formation in the inhibition of distal tubule and duct cell fates and the promotion of glomus and proximal tubule formation (By similarity). (300 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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