STRINGSTRING
SHC1 SHC1 actb actb PDGFC PDGFC LAMA1 LAMA1 actn1 actn1 pak3 pak3 pip5k1a pip5k1a GSK3B GSK3B pak4 pak4 pik3cb pik3cb PARVG PARVG sos2 sos2 EGFR EGFR ITGB4 ITGB4 comp comp pik3r2 pik3r2 ITGA11 ITGA11 JUN JUN rap1b rap1b rac2 rac2 akt2 akt2 pten pten ppp1cb ppp1cb MYLK4 MYLK4 prkca prkca VEGFD VEGFD rhoa.2 rhoa.2 egf egf ilk ilk myl2 myl2 ppp1r12b ppp1r12b itga1 itga1 itga2 itga2 VEGFC VEGFC PIK3R1 PIK3R1 pak1 pak1 crk crk hras hras mapk1 mapk1 elk1 elk1 sos1 sos1 akt1 akt1 myl9 myl9 actg1 actg1 COL9A1 COL9A1 PARVA PARVA pak2 pak2 COL4A1 COL4A1 col4a2 col4a2 myl12b myl12b pdgfb-2 pdgfb-2 bri3bp-2 bri3bp-2 fyn fyn arhgap35 arhgap35 itgav itgav src src ccndx ccndx vegfa vegfa itga8 itga8 IGF1R IGF1R TLN1 TLN1 prkcg prkcg rac3 rac3 THBS2 THBS2 ITGA5 ITGA5 col6a5 col6a5 actn4 actn4 COL4A5 COL4A5 parvb parvb IGF1 IGF1 col1a1 col1a1 col4a6 col4a6 map2k1 map2k1 col1a2 col1a2 mapk10 mapk10 mylkl mylkl itga6 itga6 BRAF BRAF BCL2 BCL2 flt4 flt4 lamc1 lamc1 pdgfra pdgfra col9a2 col9a2 prkcb prkcb mylpf mylpf raf1 raf1 shc2 shc2 LOC100487727 LOC100487727 THBS1 THBS1 thbs4 thbs4 cdc42 cdc42 rasgrf1 rasgrf1 bad bad vtn vtn ppp1cc ppp1cc birc2 birc2 PIP5K1B PIP5K1B tigar tigar shc3 shc3 rac1 rac1 LOC100496423 LOC100496423 cav3.2 cav3.2 itgb1 itgb1 ITGA9 ITGA9 rhoa rhoa chad chad LAMB1 LAMB1 pdgfa pdgfa mapk8 mapk8 vav1 vav1 bcar1 bcar1 ctnnb1 ctnnb1 PDGFD PDGFD Mylk Mylk pik3ca pik3ca pdpk1 pdpk1 rap1a rap1a erbb2 erbb2 ITGB8 ITGB8 xiap xiap TNN TNN tnr tnr cav3.1 cav3.1 itgb3 itgb3 ITGA4 ITGA4 grb2 grb2 reln reln rhoc rhoc rock2 rock2 ITGA3 ITGA3 cav2 cav2 cav1 cav1 met met FLNB FLNB myl7 myl7 fn1 fn1 LAMB2 LAMB2 pik3r3 pik3r3 TLN2 TLN2 col6a3 col6a3 LOC100170549 LOC100170549 pip5k1c pip5k1c col2a1 col2a1 HGF HGF itgb6 itgb6 arhgap5 arhgap5 pak6 pak6 DOCK1 DOCK1 PTK2 PTK2 myl10 myl10 flnc flnc
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SHC1SHC adaptor protein 1. (431 aa)
actbActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (347 aa)
LAMA1Laminin subunit alpha 1. (3101 aa)
actn1Uncharacterized protein. (890 aa)
pak3Non-specific serine/threonine protein kinase. (564 aa)
pip5k1aPIPK domain-containing protein. (468 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (434 aa)
pak4Non-specific serine/threonine protein kinase. (665 aa)
pik3cbSolute carrier family 27 member 6; Belongs to the PI3/PI4-kinase family. (1085 aa)
PARVGParvin gamma. (314 aa)
sos2Ornithine carbamoyltransferase. (1333 aa)
EGFRReceptor protein-tyrosine kinase. (1216 aa)
ITGB4Integrin beta. (1835 aa)
comptRNA phosphotransferase 1. (704 aa)
pik3r2Uncharacterized protein. (719 aa)
ITGA11Integrin subunit alpha 11; Belongs to the integrin alpha chain family. (1171 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (312 aa)
rap1bRas-related protein Rap-1b; Probable GTP-binding protein that possesses GTPase activity. May play a role in endothelial cell polarity and endothelial barrier function (By similarity); Belongs to the small GTPase superfamily. Ras family. (184 aa)
rac2Ras-related C3 botulinum toxin substrate 2 (Rho family, small GTP binding protein Rac2). (192 aa)
akt2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (486 aa)
ptenPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (402 aa)
ppp1cbSerine/threonine-protein phosphatase PP1-beta catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity (By similarity). (327 aa)
MYLK4Myosin light chain kinase family member 4. (852 aa)
prkcaR3H domain and coiled-coil-containing 1-like; Belongs to the protein kinase superfamily. (261 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (333 aa)
rhoa.2Nuclear receptor binding SET domain protein 3. (193 aa)
egfUncharacterized protein. (1051 aa)
ilkUncharacterized protein. (286 aa)
myl2Adaptor related protein complex 5 subunit zeta 1. (245 aa)
ppp1r12bPRKG1_interact domain-containing protein. (186 aa)
itga1Tetratricopeptide repeat domain 37; Belongs to the integrin alpha chain family. (1132 aa)
itga2Leucine-rich repeats and immunoglobulin like domains 2; Belongs to the integrin alpha chain family. (1177 aa)
VEGFCVascular endothelial growth factor C. (407 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (718 aa)
pak1Non-specific serine/threonine protein kinase. (521 aa)
crkMultivesicular body subunit 12B. (297 aa)
hrasChloride channel accessory 1 gene 1. (217 aa)
mapk1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (369 aa)
elk1Myosin, heavy chain 9, non-muscle. (414 aa)
sos1Organic solute transporter subunit alpha. (1329 aa)
akt1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (493 aa)
myl9LOC100124811 protein. (172 aa)
actg1Actin, cytoplasmic 2, N-terminally processed; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells; Belongs to the actin family. (375 aa)
COL9A1Collagen type IX alpha 1 chain. (543 aa)
PARVAParvin alpha. (254 aa)
pak2Non-specific serine/threonine protein kinase. (518 aa)
COL4A1Collagen type IV alpha 1 chain. (1669 aa)
col4a2Mediator of RNA polymerase II transcription subunit 27. (1722 aa)
myl12bUncharacterized protein. (173 aa)
pdgfb-2Frizzled related protein; Belongs to the PDGF/VEGF growth factor family. (240 aa)
bri3bp-2Non-specific serine/threonine protein kinase. (754 aa)
fynTyrosine-protein kinase. (538 aa)
arhgap35Bora, aurora kinase A activator. (1472 aa)
itgavRAB5B, member RAS oncogene family; Belongs to the integrin alpha chain family. (1034 aa)
srcTyrosine-protein kinase. (557 aa)
ccndxNovel cyclin; Belongs to the cyclin family. (290 aa)
vegfaGID complex subunit 8; Belongs to the PDGF/VEGF growth factor family. (311 aa)
itga8Pyrroline-5-carboxylate reductase family, member 1; Belongs to the integrin alpha chain family. (1081 aa)
IGF1RTyrosine-protein kinase receptor. (1362 aa)
TLN1Talin 1. (1813 aa)
prkcgProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (690 aa)
rac3NGFI-A binding protein 2 (EGR1 binding protein 2). (192 aa)
THBS2Thrombospondin 2. (1215 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1022 aa)
col6a5Uncharacterized protein. (2771 aa)
actn4Uncharacterized protein. (926 aa)
COL4A5Collagen type IV alpha 5 chain. (1714 aa)
parvbUncharacterized protein. (435 aa)
IGF1Insulin like growth factor 1. (153 aa)
col1a1Uncharacterized protein. (1449 aa)
col4a6Collagen IV NC1 domain-containing protein. (1706 aa)
map2k1Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the protein kinase superfamily. (395 aa)
col1a2Collagen, type 1, alpha 2. (1354 aa)
mapk10Mitogen-activated protein kinase. (496 aa)
mylklUncharacterized protein. (855 aa)
itga6Serine/arginine repetitive matrix 2; Belongs to the integrin alpha chain family. (1095 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (908 aa)
BCL2BCL2 apoptosis regulator. (293 aa)
flt4Transient receptor potential cation channel subfamily M member 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1364 aa)
lamc1Laminin subunit gamma-1; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. (1607 aa)
pdgfraPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1096 aa)
col9a2LOC100036633 protein. (686 aa)
prkcbProtein kinase C beta type; Calcium-activated and phospholipid-dependent serine/threonine-protein kinase involved in various processes such as regulation of the B-cell receptor (BCR) signalosome, apoptosis and transcription regulation. Plays a key role in B-cell activation and function by regulating BCR-induced NF-kappa-B activation and B-cell survival. Required for recruitment and activation of the IKK kinase to lipid rafts and mediates phosphorylation of card11/carma1, leading to activate the NF-kappa-B signaling. Involved in apoptosis following oxidative damage: in case of oxidative [...] (671 aa)
mylpfUncharacterized protein. (175 aa)
raf1Zona pellucida glycoprotein 4. (305 aa)
shc2Uncharacterized protein. (631 aa)
LOC100487727Protein phosphatase 1 regulatory subunit. (814 aa)
THBS1Thrombospondin 1. (1188 aa)
thbs4Uncharacterized protein. (970 aa)
cdc42Uncharacterized protein. (212 aa)
rasgrf1DNA topoisomerase I, gene 2. (1240 aa)
badSMC5-SMC6 complex localization factor 1. (151 aa)
vtnSMB domain-containing protein. (460 aa)
ppp1ccSerine/threonine-protein phosphatase PP1-gamma catalytic subunit; Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Promotes nuclear envelope reassembly by targeting nuclear membrane vesicles to chromatin at the end of mitosis. Acts by dephosphorylating membrane proteins such as lamin B receptor (lbr) to regulate the binding of membrane proteins to chromatin (By similarity); Belongs to the PPP phosphatase family. PP-1 subfamily. (329 aa)
birc2CREB3 regulatory factor. (639 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type 1 beta. (585 aa)
tigarFructose-2,6-bisphosphatase TIGAR; Fructose-bisphosphatase hydrolyzing fructose-2,6-bisphosphate as well as fructose-1,6-bisphosphate. Acts as a negative regulator of glycolysis by lowering intracellular levels of fructose-2,6- bisphosphate in a p53/TP53-dependent manner, resulting in the pentose phosphate pathway (PPP) activation and NADPH production. Contributes to the generation of reduced glutathione to cause a decrease in intracellular reactive oxygen species (ROS) content, correlating with its ability to protect cells from oxidative or metabolic stress-induced cell death. May pla [...] (554 aa)
shc3Optic atrophy 1 (autosomal dominant). (625 aa)
rac1Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1). (192 aa)
LOC100496423Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (164 aa)
cav3.2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (153 aa)
itgb1Integrin beta; Belongs to the integrin beta chain family. (808 aa)
ITGA9Integrin subunit alpha 9; Belongs to the integrin alpha chain family. (1045 aa)
rhoaRas homolog gene family, member A. (193 aa)
chadUncharacterized protein. (360 aa)
LAMB1Laminin subunit beta 1. (1808 aa)
pdgfaUncharacterized protein; Belongs to the PDGF/VEGF growth factor family. (308 aa)
mapk8Mitogen-activated protein kinase. (541 aa)
vav1V-rel avian reticuloendotheliosis viral oncogene homolog. (836 aa)
bcar1SH3 domain-containing protein. (951 aa)
ctnnb1Dynactin subunit 5. (788 aa)
PDGFDPlatelet derived growth factor D; Belongs to the PDGF/VEGF growth factor family. (389 aa)
MylkUncharacterized protein. (307 aa)
pik3caPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1067 aa)
pdpk1Protein kinase domain-containing protein. (554 aa)
rap1aAldehyde dehydrogenase 1 family member A3. (185 aa)
erbb2Receptor protein-tyrosine kinase. (1316 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (726 aa)
xiapE3 ubiquitin-protein ligase XIAP; Multi-functional protein which regulates not only caspases and apoptosis, but also acts as an E3 ubiquitin-protein ligase mediating ubiquitination and subsequent proteasomal degradation of its target proteins. Acts as a direct caspase inhibitor. A key apoptotic suppressor in eggs. Acts as a positive regulator of Wnt signaling. Belongs to the IAP family. (492 aa)
TNNTenascin N. (1093 aa)
tnrGRB2 associated binding protein 1. (1355 aa)
cav3.1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (155 aa)
itgb3Integrin beta; Belongs to the integrin beta chain family. (800 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1030 aa)
grb2Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Promotes meiotic reinitiation during oocyte maturation. (229 aa)
relnG protein-coupled receptor 119. (3463 aa)
rhocCalponin 3, acidic. (193 aa)
rock2Mediator of RNA polymerase II transcription subunit 18; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1461 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1046 aa)
cav2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (160 aa)
cav1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (180 aa)
metUTP6 small subunit processome component. (1402 aa)
FLNBFilamin B. (2667 aa)
myl7Trinucleotide repeat containing 6C. (173 aa)
fn1Fibronectin 1. (2475 aa)
LAMB2Laminin subunit beta 2. (1793 aa)
pik3r3Phosphoinositide-3-kinase, regulatory subunit, polypeptide 3 (P55, gamma). (461 aa)
TLN2Talin 2. (2545 aa)
col6a3Itchy E3 ubiquitin protein ligase. (3091 aa)
LOC100170549Uncharacterized protein. (1853 aa)
pip5k1cPIPK domain-containing protein. (688 aa)
col2a1Collagen alpha-1(II) chain; Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces (By similarity). (1492 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (710 aa)
itgb6Integrin beta; Belongs to the integrin beta chain family. (782 aa)
arhgap5Lysine-specific demethylase RSBN1L. (1500 aa)
pak6Non-specific serine/threonine protein kinase. (673 aa)
DOCK1Dedicator of cytokinesis 1; Belongs to the DOCK family. (1859 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1122 aa)
myl10LOC100170437 protein. (168 aa)
flncCoenzyme Q2 4-hydroxybenzoate polyprenyltransferase. (2728 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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