STRINGSTRING
tuba1c tuba1c ADCY1 ADCY1 GUCY1B1 GUCY1B1 PDGFC PDGFC GRM5 GRM5 LOC100498055 LOC100498055 prr16-2 prr16-2 tuba3c tuba3c gna11 gna11 tuba1a tuba1a sos2 sos2 EGFR EGFR map2k5 map2k5 htr2b htr2b prkaca prkaca nras nras gucy1b2 gucy1b2 prkca prkca egf egf hras hras mapk1 mapk1 sos1 sos1 tuba1b tuba1b pdgfb-2 pdgfb-2 plcb4 plcb4 LOC100494762 LOC100494762 tubb4a tubb4a tuba1l tuba1l src src gja1 gja1 prkcg prkcg DRD2 DRD2 lpar1 lpar1 tubb tubb prkacb prkacb tuba4b tuba4b ADCY6 ADCY6 ADCY9 ADCY9 tuba1al tuba1al mapk7 mapk7 map2k1 map2k1 adcy4 adcy4 ptrhd1 ptrhd1 csnk1d csnk1d kras kras prkg1 prkg1 tubb3 tubb3 LOC101734573 LOC101734573 pdgfra pdgfra prkcb prkcb raf1 raf1 tubb2b tubb2b cdk1 cdk1 tubb6 tubb6 gnai3 gnai3 prkg2 prkg2 gnaq gnaq tubb4b tubb4b adcy7 adcy7 htr2a htr2a gucy1a2 gucy1a2 pdgfa pdgfa DRD1 DRD1 PDGFD PDGFD HTR2C HTR2C grb2 grb2 GRM1 GRM1 wnk3 wnk3 MAP3K2 MAP3K2 itpr3 itpr3 gnai1 gnai1 GJD2 GJD2 PLCB2 PLCB2 tuba4 tuba4 tuba3e tuba3e TJP1 TJP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
tuba1cTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (449 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1118 aa)
GUCY1B1Guanylate cyclase 1 soluble subunit beta 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (636 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (347 aa)
GRM5Glutamate metabotropic receptor 5. (1172 aa)
LOC100498055cGMP-dependent protein kinase. (745 aa)
prr16-2Proline-rich 16. (94 aa)
tuba3cTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (450 aa)
gna11Guanine nucleotide binding protein (G protein), alpha 11 (Gq class). (359 aa)
tuba1aTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (450 aa)
sos2Ornithine carbamoyltransferase. (1333 aa)
EGFRReceptor protein-tyrosine kinase. (1216 aa)
map2k5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (448 aa)
htr2bRas homolog family member C. (478 aa)
prkacaIntegrator complex subunit 8; Belongs to the protein kinase superfamily. (383 aa)
nrasNovel gene of the neuroblastoma RAS viral (V-ras) oncogene homolog family. (189 aa)
gucy1b2Ankyrin 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (615 aa)
prkcaR3H domain and coiled-coil-containing 1-like; Belongs to the protein kinase superfamily. (261 aa)
egfUncharacterized protein. (1051 aa)
hrasChloride channel accessory 1 gene 1. (217 aa)
mapk1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (369 aa)
sos1Organic solute transporter subunit alpha. (1329 aa)
tuba1bTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (451 aa)
pdgfb-2Frizzled related protein; Belongs to the PDGF/VEGF growth factor family. (240 aa)
plcb41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1205 aa)
LOC100494762Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (300 aa)
tubb4aTubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (444 aa)
tuba1lTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (442 aa)
srcTyrosine-protein kinase. (557 aa)
gja1Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (379 aa)
prkcgProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (690 aa)
DRD2G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (440 aa)
lpar1LOC100124893 protein; Belongs to the G-protein coupled receptor 1 family. (366 aa)
tubbTubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). (444 aa)
prkacbUncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
tuba4bDetyrosinated tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (489 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1169 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1295 aa)
tuba1alTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (447 aa)
mapk7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (986 aa)
map2k1Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the protein kinase superfamily. (395 aa)
adcy4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1072 aa)
ptrhd1Inactive serine protease PAMR1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (915 aa)
csnk1dCasein kinase I isoform delta; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating per1 and per2, which may lead to their degradation. Participates in wnt signaling (By similarity). (441 aa)
krasV-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (186 aa)
prkg1cGMP-dependent protein kinase. (685 aa)
tubb3Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (449 aa)
LOC101734573Myocardial zonula adherens protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (132 aa)
pdgfraPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1096 aa)
prkcbProtein kinase C beta type; Calcium-activated and phospholipid-dependent serine/threonine-protein kinase involved in various processes such as regulation of the B-cell receptor (BCR) signalosome, apoptosis and transcription regulation. Plays a key role in B-cell activation and function by regulating BCR-induced NF-kappa-B activation and B-cell survival. Required for recruitment and activation of the IKK kinase to lipid rafts and mediates phosphorylation of card11/carma1, leading to activate the NF-kappa-B signaling. Involved in apoptosis following oxidative damage: in case of oxidative [...] (671 aa)
raf1Zona pellucida glycoprotein 4. (305 aa)
tubb2bTubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (445 aa)
cdk1Cell division cycle 2, G1 to S and G2 to M; Belongs to the protein kinase superfamily. (302 aa)
tubb6Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (446 aa)
gnai3Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3. (354 aa)
prkg2cGMP-dependent protein kinase. (787 aa)
gnaqGuanine nucleotide binding protein (G protein), q polypeptide. (359 aa)
tubb4bTubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (445 aa)
adcy7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1061 aa)
htr2aSolute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29. (483 aa)
gucy1a2LOC100145454 protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (712 aa)
pdgfaUncharacterized protein; Belongs to the PDGF/VEGF growth factor family. (308 aa)
DRD1Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (442 aa)
PDGFDPlatelet derived growth factor D; Belongs to the PDGF/VEGF growth factor family. (389 aa)
HTR2C5-hydroxytryptamine receptor 2C. (475 aa)
grb2Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Promotes meiotic reinitiation during oocyte maturation. (229 aa)
GRM1Glutamate metabotropic receptor 1. (1158 aa)
wnk3Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1213 aa)
MAP3K2Mitogen-activated protein kinase kinase kinase 2. (630 aa)
itpr3Inositol (1,4,5) trisphosphate receptor type 3. (2673 aa)
gnai1Uncharacterized protein. (397 aa)
GJD2Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (304 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1250 aa)
tuba4Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (450 aa)
tuba3eTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (462 aa)
TJP1Tight junction protein 1; Belongs to the MAGUK family. (1544 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.