STRINGSTRING
NFKB1 NFKB1 ADAR ADAR LOC100490493 LOC100490493 nfkbia nfkbia polr3g polr3g LOC105945198 LOC105945198 ripk1 ripk1 polr3f polr3f polr3gl polr3gl polr3e polr3e chuk chuk polr2e polr2e tmem173 tmem173 polr3d polr3d polr3h polr3h POLR1C POLR1C polr3c polr3c pycard pycard polr3k polr3k Il6 Il6 polr3b polr3b rela rela ripk3 ripk3 tbk1 tbk1 polr2l.2 polr2l.2 irf3 irf3 LOC100496716 LOC100496716 Ccl5 Ccl5 Mavs Mavs polr2h polr2h polr2f polr2f polr1d.2 polr1d.2 polr2l.1 polr2l.1 ikbkb ikbkb cxcl11 cxcl11 cxcl9 cxcl9 polr3a polr3a il1b il1b
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NFKB1Nuclear factor kappa B subunit 1. (954 aa)
ADARAdenosine deaminase RNA specific. (1119 aa)
LOC100490493Coiled-coil-helix-coiled-coil-helix domain containing 2; Belongs to the protein kinase superfamily. (421 aa)
nfkbiaNuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha. (315 aa)
polr3gUncharacterized protein. (192 aa)
LOC105945198Type I interferon 4. (189 aa)
ripk1Sequestosome 1. (669 aa)
polr3fDNA-directed RNA polymerase III subunit RPC6; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs; Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family. (317 aa)
polr3glDNA-directed RNA polymerase III subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. (215 aa)
polr3eUncharacterized protein. (701 aa)
chukInhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily. (707 aa)
polr2ePolymerase (RNA) II (DNA directed) polypeptide E. (210 aa)
tmem173Stimulator of interferon genes protein; Sensor of cytosolic DNA from bacteria and viruses that promotes autophagy. Acts by recognizing and binding cyclic GMP-AMP (cGAMP), a messenger produced by CGAS in response to DNA in the cytosol. Following cGAMP-binding, promotes the formation of autophagosomes, leading to target cytosolic DNA for degradation by the lysosome. Exhibits guanine base- specific ligand recognition. Binds 3'-3'linked cGAMP, 2'-3' linked cGAMP and 3'-3' linked c-di-GMP with much greater affinity as compared to 3'-3' linked c-di-AMP. Lacks the C-terminal tail (CTT) found [...] (329 aa)
polr3dPolymerase (RNA) III (DNA directed) polypeptide D, 44kDa. (394 aa)
polr3hMyeloid-associated differentiation marker-like 2. (227 aa)
POLR1CRNA polymerase I and III subunit C. (365 aa)
polr3cNucleoside diphosphate-linked moiety X motif 17; Probably mediates the hydrolysis of some nucleoside diphosphate derivatives; Belongs to the Nudix hydrolase family. (568 aa)
pycardFamily with sequence similarity 84 member B. (199 aa)
polr3kDNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (108 aa)
Il6Uncharacterized protein. (150 aa)
polr3bDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1142 aa)
relaGalactokinase 2. (534 aa)
ripk3Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (390 aa)
tbk1Proteasome 26S subunit, ATPase 1. (725 aa)
polr2l.2S-phase cyclin A-associated protein in the ER. (67 aa)
irf3Transmembrane 6 superfamily member 2. (470 aa)
LOC100496716Uncharacterized protein. (195 aa)
Ccl5C-C motif chemokine. (99 aa)
MavsCARD_2 domain-containing protein. (288 aa)
polr2hDNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (150 aa)
polr2fPolymerase (RNA) II (DNA directed) polypeptide F. (127 aa)
polr1d.2TIA1 cytotoxic granule-associated RNA binding protein-like 1. (128 aa)
polr2l.1Polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa. (67 aa)
ikbkbUncharacterized protein. (769 aa)
cxcl11Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family. (119 aa)
cxcl9Cyclin-dependent kinase 2 associated protein 2. (96 aa)
polr3aDNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1390 aa)
il1bInterleukin-1; Belongs to the IL-1 family. (286 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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