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SFN17400.1 SFN17400.1 SFN17001.1 SFN17001.1 thiL thiL SFN04429.1 SFN04429.1 bioB bioB SFN03583.1 SFN03583.1 SFN03499.1 SFN03499.1 SFN35820.1 SFN35820.1 metXS metXS gshB gshB SFM98878.1 SFM98878.1 accA accA metZ metZ accD accD SFM95923.1 SFM95923.1 SFN03107.1 SFN03107.1 SFN30022.1 SFN30022.1 asd asd SFN27463.1 SFN27463.1 SFN27403.1 SFN27403.1 SFN27367.1 SFN27367.1 SFN27334.1 SFN27334.1 SFN78945.1 SFN78945.1 SFN79043.1 SFN79043.1 SFN85596.1 SFN85596.1 metK metK SFO00332.1 SFO00332.1 SFO01094.1 SFO01094.1 thiG thiG SFO01394.1 SFO01394.1 SFN75435.1 SFN75435.1 dxs dxs bioB-2 bioB-2 SFN71727.1 SFN71727.1 folD folD lipA lipA SFN57680.1 SFN57680.1 bioD bioD bioC bioC SFN48850.1 SFN48850.1 thiE thiE ackA ackA SFN47932.1 SFN47932.1 bioH bioH bioF bioF thiC thiC SFN39277.1 SFN39277.1 metE metE SFN35877.1 SFN35877.1 SFN35851.1 SFN35851.1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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experimentally determined
Predicted Interactions
gene neighborhood
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SFN17400.1acetyl-CoA carboxylase, biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (455 aa)
SFN17001.1N-acetylglucosaminyl deacetylase, LmbE family. (288 aa)
thiLThiamine-phosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (316 aa)
SFN04429.1Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (435 aa)
bioBBiotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (320 aa)
SFN03583.1Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1233 aa)
SFN03499.1Pimeloyl-ACP methyl ester carboxylesterase. (299 aa)
SFN35820.1Pyruvate ferredoxin oxidoreductase, gamma subunit. (192 aa)
metXSHomoserine O-acetyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine. (379 aa)
gshBGlutathione synthase; Belongs to the prokaryotic GSH synthase family. (315 aa)
SFM98878.1Homocysteine/selenocysteine methylase (S-methylmethionine-dependent). (300 aa)
accAacetyl-CoA carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (321 aa)
metZO-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. (392 aa)
accDacetyl-CoA carboxylase carboxyl transferase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (288 aa)
SFM95923.1Homoserine dehydrogenase. (435 aa)
SFN03107.1Cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family. (310 aa)
SFN30022.1Serine O-acetyltransferase. (218 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (368 aa)
SFN27463.1Sulfite reductase (NADPH) hemoprotein beta-component. (566 aa)
SFN27403.1Phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. (234 aa)
SFN27367.1Sulfate adenylyltransferase subunit 2. (301 aa)
SFN27334.1Sulfate adenylyltransferase subunit 1; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (449 aa)
SFN78945.1Iron-only hydrogenase maturation protein HydG. (476 aa)
SFN79043.1Biotin synthase. (390 aa)
SFN85596.15,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. (274 aa)
metKMethionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (388 aa)
SFO00332.1Adenosylhomocysteine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (229 aa)
SFO01094.1Sulfur carrier protein. (67 aa)
thiGThiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (262 aa)
SFO01394.1Uncharacterized conserved protein PhnB, glyoxalase superfamily. (140 aa)
SFN75435.1Cysteine synthase B; Belongs to the cysteine synthase/cystathionine beta- synthase family. (295 aa)
dxs1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (614 aa)
bioB-2Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (334 aa)
SFN71727.1Serine O-acetyltransferase. (250 aa)
folDMethylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (284 aa)
lipALipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (325 aa)
SFN57680.1Phosphotransacetylase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (684 aa)
bioDDethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (235 aa)
bioCmalonyl-CoA O-methyltransferase; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway. (293 aa)
SFN48850.1Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase. (294 aa)
thiEThiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (202 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (398 aa)
SFN47932.1Phosphate acetyltransferase. (451 aa)
bioHPimeloyl-[acyl-carrier protein] methyl ester esterase; The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters. (255 aa)
bioF8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. (385 aa)
thiCPhosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (637 aa)
SFN39277.1LysR family transcriptional regulator, regulator for metE and metH; Belongs to the LysR transcriptional regulatory family. (306 aa)
metEMethionine synthase (B12-independent); Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (759 aa)
SFN35877.1Pyruvate ferredoxin oxidoreductase, beta subunit. (332 aa)
SFN35851.1Pyruvate ferredoxin oxidoreductase alpha subunit. (418 aa)
Your Current Organism:
Formivibrio citricus
NCBI taxonomy Id: 83765
Other names: ATCC 49791, DSM 6150, F. citricus, strain CreCit1
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