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| | gmk_1 | Guanylate kinase. (195 aa) |
| | pucK | Uric acid permease PucK. (434 aa) |
| | xpt | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. (190 aa) |
| | adeC | Adenine deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family. (572 aa) |
| | thyA1 | Thymidylate synthase 1; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (263 aa) |
| | dfrA | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (153 aa) |
| | add | Adenine deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily. (335 aa) |
| | sulD | Bifunctional folate synthesis protein; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (275 aa) |
| | folP | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (268 aa) |
| | OOL92689.1 | Phosphodiesterase. (161 aa) |
| | thrS | threonine--tRNA ligase 1. (553 aa) |
| | purR_1 | Pur operon repressor. (269 aa) |
| | mazG | Nucleoside triphosphate pyrophosphohydrolase. (494 aa) |
| | fhs | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. (556 aa) |
| | aroK_2 | Shikimate kinase. (170 aa) |
| | nrdJ | Vitamin B12-dependent ribonucleotide reductase; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (986 aa) |
| | OOL89944.1 | FRG domain protein. (470 aa) |
| | purH_1 | Bifunctional purine biosynthesis protein PurH. (391 aa) |
| | pdp | Pyrimidine-nucleoside phosphorylase. (433 aa) |
| | deoB | Phosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. (393 aa) |
| | nupC | Nucleoside permease NupC; Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family. (393 aa) |
| | deoC2 | Deoxyribose-phosphate aldolase 2; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (215 aa) |
| | cdd | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (131 aa) |
| | carB_1 | Carbamoyl-phosphate synthase large chain. (315 aa) |
| | pyrC | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (424 aa) |
| | apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (172 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (411 aa) |
| | dut | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (146 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (428 aa) |
| | folE | GTP cyclohydrolase 1. (195 aa) |
| | purE | N5-carboxyaminoimidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (159 aa) |
| | purC | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (235 aa) |
| | purF | Amidophosphoribosyltransferase precursor; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (475 aa) |
| | purM | Phosphoribosylformylglycinamidine cyclo-ligase. (332 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (204 aa) |
| | purH_2 | Bifunctional purine biosynthesis protein PurH. (499 aa) |
| | purD | Phosphoribosylamine--glycine ligase; Belongs to the GARS family. (416 aa) |
| | ghrB | Glyoxylate/hydroxypyruvate reductase B; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (315 aa) |
| | yfkN | Trifunctional nucleotide phosphoesterase protein YfkN precursor. (1194 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase 2. (1255 aa) |
| | folD | Bifunctional protein FolD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (278 aa) |
| | punA | Purine nucleoside phosphorylase 1; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (268 aa) |
| | purB | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (476 aa) |
| | fchA | Methenyltetrahydrofolate cyclohydrolase. (211 aa) |
| | OOL86676.1 | Hypothetical protein. (150 aa) |
| | nrdA | Ribonucleoside-diphosphate reductase 1 subunit alpha; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (742 aa) |
| | nrdB | Ribonucleoside-diphosphate reductase subunit beta; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (344 aa) |
| | deoD | Purine nucleoside phosphorylase DeoD-type. (253 aa) |
| | OOL85598.1 | Putative 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (183 aa) |
| | uraA | Uracil permease. (431 aa) |
| | pyrR | Bifunctional protein PyrR; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant; Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. (178 aa) |
| | grxC | Glutaredoxin-3. (76 aa) |
| | adeQ | Adenine permease AdeQ. (430 aa) |
| | guaB | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (485 aa) |
| | guaA | GMP synthase; Catalyzes the synthesis of GMP from XMP. (510 aa) |
| | pyrB | Aspartate carbamoyltransferase catalytic chain; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (307 aa) |
| | pyrI | Aspartate carbamoyltransferase regulatory chain. (146 aa) |
| | pyrF | Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. (288 aa) |
| | pyrK_2 | Dihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). (246 aa) |
| | pyrD_2 | Dihydroorotate dehydrogenase B (NAD(+)), catalytic subunit; Catalyzes the conversion of dihydroorotate to orotate. (300 aa) |
| | carA | Carbamoyl-phosphate synthase small chain; Belongs to the CarA family. (370 aa) |
| | carB_2 | Carbamoyl-phosphate synthase large chain. (1065 aa) |
| | dcd | Deoxycytidine triphosphate deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. (173 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (224 aa) |
| | gcvT | Aminomethyltransferase; Belongs to the GcvT family. (366 aa) |
| | mtaD | 5-methylthioadenosine/S-adenosylhomocysteine deaminase. (442 aa) |
| | thyX | Thymidylate synthase ThyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (439 aa) |
| | zupT | Zinc transporter ZupT. (251 aa) |
| | tdk | Thymidine kinase. (199 aa) |
| | OOL84287.1 | Hypothetical protein. (317 aa) |
| | prmC | Release factor glutamine methyltransferase; Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif; Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily. (285 aa) |
| | prfA | Peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. (359 aa) |
| | OOL84290.1 | Hypothetical protein. (192 aa) |
| | ywlE | Low molecular weight protein-tyrosine-phosphatase YwlE. (150 aa) |
| | rpiB | Ribose-5-phosphate isomerase B. (152 aa) |
| | upp | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (209 aa) |
| | OOL84297.1 | Cytidine and deoxycytidylate deaminase zinc-binding region. (162 aa) |
| | fgs | Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. (453 aa) |
