59 items (Chelonia mydas) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	BRCC3	Lys-63-specific deubiquitinase BRCC36. (340 aa)
	CDK3	Cyclin-dependent kinase 3; Belongs to the protein kinase superfamily. (308 aa)
	UY3_17734	Replication factor C subunit 4. (328 aa)
	RFC3	Replication factor C subunit 3. (327 aa)
	UY3_16896	Histone H2B; Belongs to the histone H2B family. (126 aa)
	BABAM1	BRISC and BRCA1-A complex member 1. (325 aa)
	UY3_16894	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (101 aa)
	CCNA1	Cyclin-A1; Belongs to the cyclin family. (366 aa)
	PIAS4	E3 SUMO-protein ligase PIAS4. (483 aa)
	UY3_18503	Serine/threonine-protein phosphatase 4 catalytic subunit B. (464 aa)
	RNF169	Uncharacterized protein. (638 aa)
	UY3_18438	BRCA1-A complex subunit BRE. (338 aa)
	FAM175A	BRCA1-A complex subunit Abraxas. (235 aa)
	UY3_18168	Histone H2B; Belongs to the histone H2B family. (121 aa)
	UY3_12510	Histone H2B 8; Belongs to the histone H2B family. (121 aa)
	UY3_13463	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
	UY3_00018	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
	UY3_11445	Ankyrin repeat domain-containing protein 31. (1388 aa)
	UY3_11290	DNA topoisomerase 2-binding protein 1-A. (1438 aa)
	RECQL4	ATP-dependent DNA helicase Q4. (1235 aa)
	UY3_11022	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
	UY3_08577	Histone H2B; Belongs to the histone H2B family. (126 aa)
	UY3_09899	Werner syndrome ATP-dependent helicase. (1551 aa)
	RAD50	DNA repair protein RAD50. (1312 aa)
	UY3_10496	RCC1 and BTB domain-containing protein 2. (534 aa)
	UY3_11862	Protein timeless like protein. (1076 aa)
	BARD1	BRCA1-associated RING domain protein 1. (831 aa)
	RCBTB1	RCC1 and BTB domain-containing protein 1. (537 aa)
	UY3_18879	NAD-dependent deacetylase sirtuin-6. (366 aa)
	UY3_08513	Checkpoint protein; Belongs to the HUS1 family. (256 aa)
	UBE2N	Ubiquitin-conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (142 aa)
	CDK2	Cyclin-dependent kinase 2. (279 aa)
	TOP3A	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (906 aa)
	UY3_06933	Serine-protein kinase ATM; Belongs to the PI3/PI4-kinase family. (2408 aa)
	UY3_04406	DNA endonuclease RBBP8. (855 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (574 aa)
	PPP4R2	Serine/threonine-protein phosphatase 4 regulatory subunit 2. (319 aa)
	UY3_04215	Cyclin-A2; Belongs to the cyclin family. (293 aa)
	UY3_12709	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
	RMI1	RecQ-mediated genome instability protein 1. (622 aa)
	RHNO1	Uncharacterized protein. (278 aa)
	UY3_02272	Breast cancer type 1 susceptibility protein like protein. (1317 aa)
	TIPIN	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (276 aa)
	UY3_06783	Bloom syndrome protein like protein. (1235 aa)
	UY3_00589	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
	UY3_10371	ATP-dependent DNA helicase Q4. (163 aa)
	UY3_02503	Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. (1896 aa)
	UY3_10152	Replication protein A 14 kDa subunit. (180 aa)
	NBN	Nibrin. (1008 aa)
	UY3_01679	Replication factor C subunit 2. (286 aa)
	ANKRD12	Ankyrin repeat domain-containing protein 12. (2043 aa)
	RAD9A	Cell cycle checkpoint control protein; Belongs to the rad9 family. (393 aa)
	UY3_03022	ATR-interacting protein. (1023 aa)
	UY3_06813	Tumor suppressor p53-binding protein 1. (1746 aa)
	ANKRD11	Ankyrin repeat domain-containing protein 11. (2609 aa)
	UY3_06517	Cell cycle checkpoint protein RAD17. (507 aa)
	DNA2	DNA2-like helicase. (1022 aa)
	UBE2V2	Ubiquitin-conjugating enzyme E2 variant 2. (140 aa)
	UY3_03389	Putative histone-lysine N-methyltransferase NSD2. (1367 aa)

Your Current Organism:

Chelonia mydas

NCBI taxonomy Id: 8469
Other names: C. mydas, Chelonia midas, Chelonia mydas caranigra, Green sea turtle, Testudo mydas, green seaturtle

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANKRD11	BABAM1	M7C6T8	M7AN18	Ankyrin repeat domain-containing protein 11.	BRISC and BRCA1-A complex member 1.	0.546
ANKRD11	BRCC3	M7C6T8	M7C3W8	Ankyrin repeat domain-containing protein 11.	Lys-63-specific deubiquitinase BRCC36.	0.585
ANKRD11	DNA2	M7C6T8	M7C7N2	Ankyrin repeat domain-containing protein 11.	DNA2-like helicase.	0.502
ANKRD11	NBN	M7C6T8	M7BYH0	Ankyrin repeat domain-containing protein 11.	Nibrin.	0.718
ANKRD11	RAD50	M7C6T8	M7B560	Ankyrin repeat domain-containing protein 11.	DNA repair protein RAD50.	0.646
ANKRD11	RFC3	M7C6T8	M7ALF6	Ankyrin repeat domain-containing protein 11.	Replication factor C subunit 3.	0.400
ANKRD11	RMI1	M7C6T8	M7BQJ0	Ankyrin repeat domain-containing protein 11.	RecQ-mediated genome instability protein 1.	0.429
ANKRD11	RPA1	M7C6T8	M7BKU9	Ankyrin repeat domain-containing protein 11.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.417
ANKRD11	TOP3A	M7C6T8	M7BIP5	Ankyrin repeat domain-containing protein 11.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.400
ANKRD11	UBE2N	M7C6T8	M7BFD2	Ankyrin repeat domain-containing protein 11.	Ubiquitin-conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family.	0.437
ANKRD11	UBE2V2	M7C6T8	M7C7Y8	Ankyrin repeat domain-containing protein 11.	Ubiquitin-conjugating enzyme E2 variant 2.	0.422
ANKRD11	UY3_02272	M7C6T8	M7BTK9	Ankyrin repeat domain-containing protein 11.	Breast cancer type 1 susceptibility protein like protein.	0.858
ANKRD11	UY3_03022	M7C6T8	M7C5I9	Ankyrin repeat domain-containing protein 11.	ATR-interacting protein.	0.411
ANKRD11	UY3_04406	M7C6T8	M7BKH6	Ankyrin repeat domain-containing protein 11.	DNA endonuclease RBBP8.	0.795
ANKRD11	UY3_06813	M7C6T8	M7C697	Ankyrin repeat domain-containing protein 11.	Tumor suppressor p53-binding protein 1.	0.481
ANKRD11	UY3_06933	M7C6T8	M7BJM5	Ankyrin repeat domain-containing protein 11.	Serine-protein kinase ATM; Belongs to the PI3/PI4-kinase family.	0.506
ANKRD11	UY3_08513	M7C6T8	M7BB11	Ankyrin repeat domain-containing protein 11.	Checkpoint protein; Belongs to the HUS1 family.	0.409
ANKRD11	UY3_09899	M7C6T8	M7B4V2	Ankyrin repeat domain-containing protein 11.	Werner syndrome ATP-dependent helicase.	0.439
ANKRD11	UY3_10152	M7C6T8	M7BX56	Ankyrin repeat domain-containing protein 11.	Replication protein A 14 kDa subunit.	0.445
ANKRD11	UY3_11290	M7C6T8	M7B3A9	Ankyrin repeat domain-containing protein 11.	DNA topoisomerase 2-binding protein 1-A.	0.736