STRINGSTRING
S1PR4 S1PR4 GRB2 GRB2 GABARAPL1 GABARAPL1 KRAS KRAS INSR INSR FOXG1 FOXG1 MAP2K2 MAP2K2 PIK3R3 PIK3R3 TGFBR2 TGFBR2 CSNK1E CSNK1E KLF2 KLF2 GADD45B GADD45B CCNG2 CCNG2 IL10 IL10 TGFB2 TGFB2 PDPK1 PDPK1 MDM2 MDM2 MAPK13 MAPK13 PRKAG1 PRKAG1 HOMER3 HOMER3 FOXO1 FOXO1 S1PR1 S1PR1 IKBKB IKBKB AKT2 AKT2 CDKN1A CDKN1A HOMER1 HOMER1 INS INS UY3_08385 UY3_08385 SETD7 SETD7 GADD45G GADD45G UY3_12318 UY3_12318 PLK4 PLK4 PLK3 PLK3 SMAD3 SMAD3 CDK2 CDK2 PIK3R1 PIK3R1 CCND1 CCND1 SGK2 SGK2 CDKN1B CDKN1B PRKAA2 PRKAA2 TGFBR1 TGFBR1 HOMER2 HOMER2 PLK1 PLK1 GABARAPL2 GABARAPL2 CCNB3 CCNB3 UY3_12317 UY3_12317 UY3_02264 UY3_02264 RAG1 RAG1 HRAS HRAS G6PC2 G6PC2 GRM1 GRM1 TGFB3 TGFB3 PCK1 PCK1 NRAS NRAS IGF1R IGF1R IRS1 IRS1 UY3_00556 UY3_00556 BCL6 BCL6 UY3_04345 UY3_04345 FASLG FASLG RAG2 RAG2 UY3_02266 UY3_02266 FOXO3 FOXO3 CCNB2 CCNB2 STAT3 STAT3 UY3_02265 UY3_02265 SIRT1 SIRT1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
S1PR4Sphingosine 1-phosphate receptor 4; Belongs to the G-protein coupled receptor 1 family. (342 aa)
GRB2Growth factor receptor-bound protein 2. (191 aa)
GABARAPL1Gamma-aminobutyric acid receptor-associated protein-like 1. (117 aa)
KRASGTPase KRas. (189 aa)
INSRMyosin-IXb; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2575 aa)
FOXG1Forkhead box protein G1. (365 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (430 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (463 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (525 aa)
CSNK1ECasein kinase I isoform epsilon; Belongs to the protein kinase superfamily. (416 aa)
KLF2Krueppel-like factor 2. (389 aa)
GADD45BGrowth arrest and DNA damage-inducible protein GADD45 beta. (189 aa)
CCNG2Cyclin-G2; Belongs to the cyclin family. (337 aa)
IL10Interleukin-10. (177 aa)
TGFB2Transforming growth factor beta-2. (198 aa)
PDPK13-phosphoinositide-dependent protein kinase 1. (554 aa)
MDM2E3 ubiquitin-protein ligase Mdm2. (191 aa)
MAPK13Mitogen-activated protein kinase. (373 aa)
PRKAG15'-AMP-activated protein kinase subunit gamma-1. (284 aa)
HOMER3Homer protein like protein 3. (387 aa)
FOXO1Forkhead box protein O1. (401 aa)
S1PR1Sphingosine 1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (380 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta. (719 aa)
AKT2Non-specific serine/threonine protein kinase. (884 aa)
CDKN1ARRM domain-containing protein; Belongs to the CRISP family. (1504 aa)
HOMER1Homer protein like protein 1. (280 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (107 aa)
UY3_083855'-AMP-activated protein kinase subunit beta-2. (274 aa)
SETD7Histone-lysine N-methyltransferase SETD7. (351 aa)
GADD45GGrowth arrest and DNA damage-inducible protein GADD45 gamma. (162 aa)
UY3_12318Cyclin-dependent kinase 4 inhibitor B. (233 aa)
PLK4Serine/threonine-protein kinase PLK4. (972 aa)
PLK3Serine/threonine-protein kinase PLK3. (595 aa)
SMAD3Mothers against decapentaplegic homolog. (378 aa)
CDK2Cyclin-dependent kinase 2. (279 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha. (677 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (292 aa)
SGK2Non-specific serine/threonine protein kinase. (839 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (199 aa)
PRKAA2Non-specific serine/threonine protein kinase. (433 aa)
TGFBR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (483 aa)
HOMER2Homer protein like protein 2. (354 aa)
PLK1Serine/threonine-protein kinase PLK1. (570 aa)
GABARAPL2Gamma-aminobutyric acid receptor-associated protein-like 2. (87 aa)
CCNB3G2/mitotic-specific cyclin-B3; Belongs to the cyclin family. (407 aa)
UY3_12317Cyclin-dependent kinase 4 inhibitor B. (136 aa)
UY3_02264Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
RAG1V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (219 aa)
HRASGTPase HRas. (189 aa)
G6PC2Glucose-6-phosphatase 2. (357 aa)
GRM1Metabotropic glutamate receptor 1. (338 aa)
TGFB3Transforming growth factor beta-3. (770 aa)
PCK1Phosphoenolpyruvate carboxykinase, cytosolic [GTP]. (622 aa)
NRASCold shock domain-containing protein E1. (945 aa)
IGF1RTyrosine-protein kinase receptor. (1149 aa)
IRS1Insulin receptor substrate 1. (910 aa)
UY3_00556BCL2/adenovirus E1B 19 kDa protein-interacting protein 3. (73 aa)
BCL6B-cell lymphoma 6 protein like protein. (805 aa)
UY3_04345Cyclin-dependent kinase inhibitor 1. (202 aa)
FASLGTumor necrosis factor ligand superfamily member 6; Belongs to the tumor necrosis factor family. (122 aa)
RAG2V(D)J recombination-activating protein 2. (526 aa)
UY3_02266Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (353 aa)
FOXO3Forkhead box protein O3. (482 aa)
CCNB2G2/mitotic-specific cyclin-B2; Belongs to the cyclin family. (1276 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
UY3_02265Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
SIRT1NAD-dependent deacetylase sirtuin-1. (616 aa)
Your Current Organism:
Chelonia mydas
NCBI taxonomy Id: 8469
Other names: C. mydas, Chelonia midas, Chelonia mydas caranigra, Green sea turtle, Testudo mydas, green seaturtle
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