STRINGSTRING
ORC2 ORC2 CCNA1 CCNA1 ANAPC10 ANAPC10 YWHAB YWHAB ANAPC2 ANAPC2 YWHAG YWHAG CCNE2 CCNE2 CDC26 CDC26 DBF4 DBF4 WEE2 WEE2 GADD45B GADD45B RAD21 RAD21 CDC23 CDC23 TGFB2 TGFB2 UY3_11911 UY3_11911 FZR1 FZR1 MDM2 MDM2 TFDP1 TFDP1 UY3_15713 UY3_15713 CDC14A CDC14A ORC3 ORC3 CDKN2C CDKN2C ORC1 ORC1 CDKN1A CDKN1A SMC1B SMC1B CDK4 CDK4 RB1 RB1 MCM3 MCM3 CDKN1C CDKN1C TTK TTK GADD45G GADD45G UY3_12318 UY3_12318 MCM2 MCM2 MAD1L1 MAD1L1 SMAD3 SMAD3 CDK2 CDK2 CUL1 CUL1 ESPL1 ESPL1 ABL1 ABL1 PRKDC PRKDC CDK6 CDK6 CCND1 CCND1 CDC16 CDC16 HDAC2 HDAC2 WEE1 WEE1 CDKN1B CDKN1B PLK1 PLK1 CDC25A CDC25A CCNB3 CCNB3 YWHAH YWHAH UY3_12317 UY3_12317 SMAD2 SMAD2 CDK1 CDK1 TGFB3 TGFB3 MAD2L2 MAD2L2 SMC3 SMC3 YWHAQ YWHAQ CCNH CCNH CDC6 CDC6 CDC20 CDC20 BUB3 BUB3 UY3_04345 UY3_04345 STAG1 STAG1 CDK7 CDK7 ANAPC7 ANAPC7 ANAPC5 ANAPC5 PTTG1 PTTG1 CCNB2 CCNB2 E2F3 E2F3 UY3_01613 UY3_01613
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ORC2Uncharacterized protein. (1101 aa)
CCNA1Cyclin-A1; Belongs to the cyclin family. (366 aa)
ANAPC10Anaphase-promoting complex subunit 10. (157 aa)
YWHAB14-3-3 protein beta/alpha; Belongs to the 14-3-3 family. (246 aa)
ANAPC2Anaphase-promoting complex subunit 2; Belongs to the cullin family. (787 aa)
YWHAG14-3-3 protein gamma; Belongs to the 14-3-3 family. (313 aa)
CCNE2G1/S-specific cyclin-E2. (334 aa)
CDC26Anaphase-promoting complex subunit CDC26. (83 aa)
DBF4Protein DBF4 like protein A. (488 aa)
WEE2Wee1-like protein kinase 2. (579 aa)
GADD45BGrowth arrest and DNA damage-inducible protein GADD45 beta. (189 aa)
RAD21Double-strand-break repair protein rad21 like protein. (589 aa)
CDC23Cell division cycle protein 23 like protein. (589 aa)
TGFB2Transforming growth factor beta-2. (198 aa)
UY3_11911M-phase inducer phosphatase 1-B. (469 aa)
FZR1Fizzy-related protein like protein. (637 aa)
MDM2E3 ubiquitin-protein ligase Mdm2. (191 aa)
TFDP1Transcription factor Dp-1. (385 aa)
UY3_1571314-3-3 protein zeta; Belongs to the 14-3-3 family. (203 aa)
CDC14ADual specificity protein phosphatase CDC14A. (115 aa)
ORC3Origin recognition complex subunit 3. (655 aa)
CDKN2CCyclin-dependent kinase 4 inhibitor C. (169 aa)
ORC1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (839 aa)
CDKN1ARRM domain-containing protein; Belongs to the CRISP family. (1504 aa)
SMC1BStructural maintenance of chromosomes protein. (1238 aa)
CDK4Cyclin-dependent kinase 4. (299 aa)
RB1Retinoblastoma-associated protein. (220 aa)
MCM3DNA helicase; Belongs to the MCM family. (795 aa)
CDKN1CCyclin-dependent kinase inhibitor 1C. (215 aa)
TTKDual specificity protein kinase TTK. (859 aa)
GADD45GGrowth arrest and DNA damage-inducible protein GADD45 gamma. (162 aa)
UY3_12318Cyclin-dependent kinase 4 inhibitor B. (233 aa)
MCM2DNA helicase; Belongs to the MCM family. (893 aa)
MAD1L1Mitotic spindle assembly checkpoint protein MAD1. (329 aa)
SMAD3Mothers against decapentaplegic homolog. (378 aa)
CDK2Cyclin-dependent kinase 2. (279 aa)
CUL1Cullin-1; Belongs to the cullin family. (412 aa)
ESPL1Separin. (2238 aa)
ABL1Tyrosine-protein kinase. (1098 aa)
PRKDCDNA-dependent protein kinase catalytic subunit; Belongs to the PI3/PI4-kinase family. (4085 aa)
CDK6Cyclin-dependent kinase 6. (393 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (292 aa)
CDC16Cell division cycle protein 16 like protein. (692 aa)
HDAC2Histone deacetylase 2. (446 aa)
WEE1Wee1-like protein kinase. (566 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (199 aa)
PLK1Serine/threonine-protein kinase PLK1. (570 aa)
CDC25AM-phase inducer phosphatase 1. (721 aa)
CCNB3G2/mitotic-specific cyclin-B3; Belongs to the cyclin family. (407 aa)
YWHAH14-3-3 protein eta; Belongs to the 14-3-3 family. (247 aa)
UY3_12317Cyclin-dependent kinase 4 inhibitor B. (136 aa)
SMAD2Mothers against decapentaplegic like protein 2. (240 aa)
CDK1Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (302 aa)
TGFB3Transforming growth factor beta-3. (770 aa)
MAD2L2Mitotic spindle assembly checkpoint protein MAD2B. (185 aa)
SMC3Structural maintenance of chromosomes protein 3. (1488 aa)
YWHAQ14-3-3 protein theta; Belongs to the 14-3-3 family. (522 aa)
CCNHCyclin-H; Belongs to the cyclin family. (244 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (557 aa)
CDC20Cell division cycle protein 20 like protein. (511 aa)
BUB3Mitotic checkpoint protein BUB3. (244 aa)
UY3_04345Cyclin-dependent kinase inhibitor 1. (202 aa)
STAG1Cohesin subunit SA-1. (145 aa)
CDK7Cyclin-dependent kinase 7. (406 aa)
ANAPC7Anaphase-promoting complex subunit 7. (841 aa)
ANAPC5Anaphase-promoting complex subunit 5. (685 aa)
PTTG1Securin. (188 aa)
CCNB2G2/mitotic-specific cyclin-B2; Belongs to the cyclin family. (1276 aa)
E2F3Transcription factor E2F3. (307 aa)
UY3_01613Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (287 aa)
Your Current Organism:
Chelonia mydas
NCBI taxonomy Id: 8469
Other names: C. mydas, Chelonia midas, Chelonia mydas caranigra, Green sea turtle, Testudo mydas, green seaturtle
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