(33 nodes) Homologous recombination network (Clostridium frigidicarnis)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SFA79645.1	Single-strand DNA-binding protein. (110 aa)
	SFA81649.1	Transcriptional regulator, AbrB family. (81 aa)
	recO	DNA replication and repair protein RecO; Involved in DNA repair and RecF pathway recombination. (214 aa)
	SFA75399.1	DNA polymerase III, delta subunit. (340 aa)
	SFA76923.1	Hypothetical protein. (277 aa)
	ruvB	Holliday junction DNA helicase subunit RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (343 aa)
	ruvA	Holliday junction DNA helicase subunit RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (199 aa)
	SFA69495.1	Single-stranded DNA-binding protein. (239 aa)
	SFB34980.1	DNA polymerase-3 subunit delta'. (311 aa)
	SFB32213.1	Single-strand binding protein. (161 aa)
	polA	DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. (865 aa)
	recR	DNA replication and repair protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (198 aa)
	dnaX	DNA polymerase-3 subunit gamma/tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (547 aa)
	SFB45306.1	Peptidyl-prolyl cis-trans isomerase C. (248 aa)
	SFB45299.1	Hypothetical protein. (205 aa)
	recF	DNA replication and repair protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP; Belongs to the RecF family. (361 aa)
	SFB43821.1	DNA polymerase-3 subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of re [...] (367 aa)
	SFB42526.1	Fic/DOC family protein. (261 aa)
	SFB38488.1	Predicted DNA-binding transcriptional regulator YafY, contains an HTH and WYL domains. (320 aa)
	priA	Replication restart DNA helicase PriA; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (735 aa)
	recG	ATP-dependent DNA helicase RecG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (677 aa)
	SFB23063.1	Exonuclease RecJ. (584 aa)
	SFB22487.1	DNA polymerase-3 subunit epsilon. (205 aa)
	prsA	Foldase protein PrsA; Plays a major role in protein secretion by helping the post- translocational extracellular folding of several secreted proteins. (333 aa)
	SFB10983.1	Predicted DNA-binding transcriptional regulator YafY, contains an HTH and WYL domains. (302 aa)
	SFB08686.1	DNA polymerase-3 subunit alpha. (1206 aa)
	SFB08046.1	AAA domain-containing protein, putative AbiEii toxin, Type IV TA system. (342 aa)
	recD2	Exodeoxyribonuclease V alpha subunit; DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity; Belongs to the RecD family. RecD-like subfamily. (743 aa)
	SFA99712.1	Looped-hinge helix DNA binding domain-containing protein, AbrB family. (76 aa)
	SFA99584.1	Hypothetical protein. (213 aa)
	SFA98930.1	ATP-dependent DNA helicase RecG. (388 aa)
	polC	DNA polymerase III catalytic subunit, PolC type; Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (1444 aa)
	recA	RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (347 aa)

Your Current Organism:

Clostridium frigidicarnis

NCBI taxonomy Id: 84698
Other names: ATCC BAA-154, C. frigidicarnis, DSM 12271, strain SPL77A

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SFA69495.1	SFA79645.1	SAMN04488528_100144	SAMN04488528_100317	Single-stranded DNA-binding protein.	Single-strand DNA-binding protein.	0.701
SFA69495.1	SFB08686.1	SAMN04488528_100144	SAMN04488528_101159	Single-stranded DNA-binding protein.	DNA polymerase-3 subunit alpha.	0.907
SFA69495.1	SFB32213.1	SAMN04488528_100144	SAMN04488528_102914	Single-stranded DNA-binding protein.	Single-strand binding protein.	0.703
SFA69495.1	SFB34980.1	SAMN04488528_100144	SAMN04488528_103227	Single-stranded DNA-binding protein.	DNA polymerase-3 subunit delta'.	0.902
SFA69495.1	SFB43821.1	SAMN04488528_100144	SAMN04488528_105610	Single-stranded DNA-binding protein.	DNA polymerase-3 subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of re [...]	0.422
SFA69495.1	dnaX	SAMN04488528_100144	SAMN04488528_10812	Single-stranded DNA-binding protein.	DNA polymerase-3 subunit gamma/tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.	0.874
SFA69495.1	polA	SAMN04488528_100144	SAMN04488528_102831	Single-stranded DNA-binding protein.	DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.	0.523
SFA69495.1	priA	SAMN04488528_100144	SAMN04488528_10238	Single-stranded DNA-binding protein.	Replication restart DNA helicase PriA; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily.	0.864
SFA69495.1	recD2	SAMN04488528_100144	SAMN04488528_1010118	Single-stranded DNA-binding protein.	Exodeoxyribonuclease V alpha subunit; DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity; Belongs to the RecD family. RecD-like subfamily.	0.447
SFA69495.1	recO	SAMN04488528_100144	SAMN04488528_100279	Single-stranded DNA-binding protein.	DNA replication and repair protein RecO; Involved in DNA repair and RecF pathway recombination.	0.437
SFA75399.1	SFB08686.1	SAMN04488528_100255	SAMN04488528_101159	DNA polymerase III, delta subunit.	DNA polymerase-3 subunit alpha.	0.990
SFA75399.1	SFB22487.1	SAMN04488528_100255	SAMN04488528_10191	DNA polymerase III, delta subunit.	DNA polymerase-3 subunit epsilon.	0.976
SFA75399.1	SFB34980.1	SAMN04488528_100255	SAMN04488528_103227	DNA polymerase III, delta subunit.	DNA polymerase-3 subunit delta'.	0.993
SFA75399.1	SFB43821.1	SAMN04488528_100255	SAMN04488528_105610	DNA polymerase III, delta subunit.	DNA polymerase-3 subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of re [...]	0.994
SFA75399.1	dnaX	SAMN04488528_100255	SAMN04488528_10812	DNA polymerase III, delta subunit.	DNA polymerase-3 subunit gamma/tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.	0.993
SFA75399.1	polA	SAMN04488528_100255	SAMN04488528_102831	DNA polymerase III, delta subunit.	DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.	0.797
SFA75399.1	polC	SAMN04488528_100255	SAMN04488528_1005192	DNA polymerase III, delta subunit.	DNA polymerase III catalytic subunit, PolC type; Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity.	0.908
SFA75399.1	recO	SAMN04488528_100255	SAMN04488528_100279	DNA polymerase III, delta subunit.	DNA replication and repair protein RecO; Involved in DNA repair and RecF pathway recombination.	0.458
SFA75399.1	recR	SAMN04488528_100255	SAMN04488528_10814	DNA polymerase III, delta subunit.	DNA replication and repair protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.	0.445
SFA76923.1	SFA79645.1	SAMN04488528_1002140	SAMN04488528_100317	Hypothetical protein.	Single-strand DNA-binding protein.	0.461