(6 nodes) Activated NTRK2 signals through FRS2 and FRS3, and Protein-tyrosine phosphatase, non-receptor type-6, -11 network (Alligator mississippiensis)

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second shell of interactors

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Known Interactions

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experimentally determined

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gene neighborhood

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textmining

co-expression

protein homology

Your Input:
	SOS1-2	Son of sevenless-like protein. (1379 aa)
	GRB2	Growth factor receptor-bound protein 2. (217 aa)
	SOS1-1	Son of sevenless-like protein 1 isoform A. (1305 aa)
	Y1Q_0006103	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (608 aa)
	FRS2	Fibroblast growth factor receptor substrate 2. (510 aa)

Your Current Organism:

Alligator mississippiensis

NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FRS2	GRB2	A0A151PF84	A0A151N2T8	Fibroblast growth factor receptor substrate 2.	Growth factor receptor-bound protein 2.	0.963
FRS2	PTPN11	A0A151PF84	A0A151NSB1	Fibroblast growth factor receptor substrate 2.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.908
FRS2	SOS1-1	A0A151PF84	A0A151N3P0	Fibroblast growth factor receptor substrate 2.	Son of sevenless-like protein 1 isoform A.	0.798
FRS2	SOS1-2	A0A151PF84	A0A151M1Q1	Fibroblast growth factor receptor substrate 2.	Son of sevenless-like protein.	0.893
FRS2	Y1Q_0006103	A0A151PF84	A0A151N4C4	Fibroblast growth factor receptor substrate 2.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.908
GRB2	FRS2	A0A151N2T8	A0A151PF84	Growth factor receptor-bound protein 2.	Fibroblast growth factor receptor substrate 2.	0.963
GRB2	PTPN11	A0A151N2T8	A0A151NSB1	Growth factor receptor-bound protein 2.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.956
GRB2	SOS1-1	A0A151N2T8	A0A151N3P0	Growth factor receptor-bound protein 2.	Son of sevenless-like protein 1 isoform A.	0.998
GRB2	SOS1-2	A0A151N2T8	A0A151M1Q1	Growth factor receptor-bound protein 2.	Son of sevenless-like protein.	0.999
GRB2	Y1Q_0006103	A0A151N2T8	A0A151N4C4	Growth factor receptor-bound protein 2.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.956
PTPN11	FRS2	A0A151NSB1	A0A151PF84	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	Fibroblast growth factor receptor substrate 2.	0.908
PTPN11	GRB2	A0A151NSB1	A0A151N2T8	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	Growth factor receptor-bound protein 2.	0.956
PTPN11	SOS1-1	A0A151NSB1	A0A151N3P0	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	Son of sevenless-like protein 1 isoform A.	0.786
PTPN11	SOS1-2	A0A151NSB1	A0A151M1Q1	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	Son of sevenless-like protein.	0.950
PTPN11	Y1Q_0006103	A0A151NSB1	A0A151N4C4	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.901
SOS1-1	FRS2	A0A151N3P0	A0A151PF84	Son of sevenless-like protein 1 isoform A.	Fibroblast growth factor receptor substrate 2.	0.798
SOS1-1	GRB2	A0A151N3P0	A0A151N2T8	Son of sevenless-like protein 1 isoform A.	Growth factor receptor-bound protein 2.	0.998
SOS1-1	PTPN11	A0A151N3P0	A0A151NSB1	Son of sevenless-like protein 1 isoform A.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.786
SOS1-1	SOS1-2	A0A151N3P0	A0A151M1Q1	Son of sevenless-like protein 1 isoform A.	Son of sevenless-like protein.	0.931
SOS1-1	Y1Q_0006103	A0A151N3P0	A0A151N4C4	Son of sevenless-like protein 1 isoform A.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.786