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PML | Protein PML isoform B. (586 aa) | ||||
MDM4 | Protein Mdm4. (513 aa) | ||||
TP63 | Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (730 aa) | ||||
TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa) | ||||
Y1Q_0006003 | Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (688 aa) | ||||
RCHY1 | RING finger and CHY zinc finger domain-containing protein 1. (210 aa) | ||||
DCLRE1B | 5' exonuclease Apollo isoform B. (1619 aa) | ||||
HIPK2 | Protein kinase domain-containing protein. (1175 aa) | ||||
PIN1 | Peptidyl-prolyl cis-trans isomerase. (159 aa) | ||||
RNF4 | E3 ubiquitin-protein ligase RNF4. (194 aa) | ||||
MDM2 | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (494 aa) |