(20 nodes) TRP channels, and Orai superfamily network (Alligator mississippiensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	STIM1	Stromal interaction molecule 1 isoform A. (706 aa)
	TRPC3	Short transient receptor potential channel 3 isoform B; Belongs to the transient receptor (TC 1.A.4) family. (858 aa)
	MCOLN1	Mucolipin-1 isoform B. (617 aa)
	TRPM1A	Transient receptor potential cation channel, subfamily M, member 1a isoform A. (865 aa)
	TRPA1	Transient receptor potential cation channel subfamily A member 1; Belongs to the transient receptor (TC 1.A.4) family. (1114 aa)
	TRPC4	Short transient receptor potential channel 4; Belongs to the transient receptor (TC 1.A.4) family. (975 aa)
	PLCL2	Phosphoinositide phospholipase C. (1115 aa)
	ORAI2	Uncharacterized protein. (273 aa)
	TRPM8	Uncharacterized protein. (1065 aa)
	TRPV4L	Transient receptor potential cation channel subfamily V member 4 isoform B; Belongs to the transient receptor (TC 1.A.4) family. (773 aa)
	TRPV2-2	ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (773 aa)
	TRPV2	Transient receptor potential cation channel subfamily V member 2; Belongs to the transient receptor (TC 1.A.4) family. (786 aa)
	TRPC1	Uncharacterized protein. (100 aa)
	TRPM5	Transient receptor potential cation channel subfamily M member 5. (1476 aa)
	MCOLN3	PKD_channel domain-containing protein. (596 aa)
	MCOLN2	PKD_channel domain-containing protein. (465 aa)
	TRPC5	Uncharacterized protein; Belongs to the transient receptor (TC 1.A.4) family. (989 aa)
	ORAI1	Calcium release-activated calcium channel protein 1. (225 aa)
	KIF13B	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1984 aa)
	STIM2	SAM domain-containing protein. (696 aa)

Your Current Organism:

Alligator mississippiensis

NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KIF13B	TRPM1A	A0A151P1X6	A0A151M8F3	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Transient receptor potential cation channel, subfamily M, member 1a isoform A.	0.526
KIF13B	TRPV2	A0A151P1X6	A0A151NAH9	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Transient receptor potential cation channel subfamily V member 2; Belongs to the transient receptor (TC 1.A.4) family.	0.430
MCOLN1	MCOLN2	A0A151M7L3	A0A151NJ03	Mucolipin-1 isoform B.	PKD_channel domain-containing protein.	0.939
MCOLN1	MCOLN3	A0A151M7L3	A0A151NJ02	Mucolipin-1 isoform B.	PKD_channel domain-containing protein.	0.902
MCOLN1	TRPA1	A0A151M7L3	A0A151MN88	Mucolipin-1 isoform B.	Transient receptor potential cation channel subfamily A member 1; Belongs to the transient receptor (TC 1.A.4) family.	0.496
MCOLN1	TRPM5	A0A151M7L3	A0A151NGW3	Mucolipin-1 isoform B.	Transient receptor potential cation channel subfamily M member 5.	0.608
MCOLN2	MCOLN1	A0A151NJ03	A0A151M7L3	PKD_channel domain-containing protein.	Mucolipin-1 isoform B.	0.939
MCOLN2	MCOLN3	A0A151NJ03	A0A151NJ02	PKD_channel domain-containing protein.	PKD_channel domain-containing protein.	0.939
MCOLN2	TRPA1	A0A151NJ03	A0A151MN88	PKD_channel domain-containing protein.	Transient receptor potential cation channel subfamily A member 1; Belongs to the transient receptor (TC 1.A.4) family.	0.496
MCOLN2	TRPM5	A0A151NJ03	A0A151NGW3	PKD_channel domain-containing protein.	Transient receptor potential cation channel subfamily M member 5.	0.608
MCOLN3	MCOLN1	A0A151NJ02	A0A151M7L3	PKD_channel domain-containing protein.	Mucolipin-1 isoform B.	0.902
MCOLN3	MCOLN2	A0A151NJ02	A0A151NJ03	PKD_channel domain-containing protein.	PKD_channel domain-containing protein.	0.939
MCOLN3	TRPA1	A0A151NJ02	A0A151MN88	PKD_channel domain-containing protein.	Transient receptor potential cation channel subfamily A member 1; Belongs to the transient receptor (TC 1.A.4) family.	0.496
MCOLN3	TRPM5	A0A151NJ02	A0A151NGW3	PKD_channel domain-containing protein.	Transient receptor potential cation channel subfamily M member 5.	0.608
ORAI1	ORAI2	A0A151NSH5	A0A151N5B2	Calcium release-activated calcium channel protein 1.	Uncharacterized protein.	0.900
ORAI1	STIM1	A0A151NSH5	A0A151M199	Calcium release-activated calcium channel protein 1.	Stromal interaction molecule 1 isoform A.	0.966
ORAI1	STIM2	A0A151NSH5	A0A151P9X8	Calcium release-activated calcium channel protein 1.	SAM domain-containing protein.	0.995
ORAI1	TRPC1	A0A151NSH5	A0A151NAP7	Calcium release-activated calcium channel protein 1.	Uncharacterized protein.	0.786
ORAI2	ORAI1	A0A151N5B2	A0A151NSH5	Uncharacterized protein.	Calcium release-activated calcium channel protein 1.	0.900
ORAI2	STIM1	A0A151N5B2	A0A151M199	Uncharacterized protein.	Stromal interaction molecule 1 isoform A.	0.857