STRINGSTRING
PAN2 PAN2 LRRC27 LRRC27 PNLDC1 PNLDC1 CNOT3-2 CNOT3-2 CNOT3-1 CNOT3-1 CNOT6L CNOT6L CNOT6L-2 CNOT6L-2 PAN3 PAN3 SAMD4B SAMD4B PARN PARN SAMD4A SAMD4A MLH1 MLH1 CNOT2 CNOT2 CNOT7 CNOT7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PAN2PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent [...] (1115 aa)
LRRC27Leucine-rich repeat-containing protein 27 isoform C. (481 aa)
PNLDC1Poly(A)-specific ribonuclease PARN-like domain-containing protein 1 isoform B. (534 aa)
CNOT3-2CCR4-NOT transcription complex subunit 3. (264 aa)
CNOT3-1CCR4-NOT transcription complex subunit 3. (456 aa)
CNOT6LCCR4-NOT transcription complex subunit 6-like. (627 aa)
CNOT6L-2Endo/exonuclease/phosphatase domain-containing protein. (594 aa)
PAN3PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA deca [...] (760 aa)
SAMD4BSmaug-like protein 2. (684 aa)
PARNPoly(A)-specific ribonuclease PARN. (638 aa)
SAMD4ASAM domain-containing protein. (705 aa)
MLH1DNA mismatch repair protein Mlh1. (750 aa)
CNOT2CCR4-NOT transcription complex subunit 2 isoform A. (561 aa)
CNOT7CCR4-NOT transcription complex subunit 7. (262 aa)
Your Current Organism:
Alligator mississippiensis
NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator
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