STRINGSTRING
PGF-1 PGF-1 CPEB1 CPEB1 HIF1AN HIF1AN VHL VHL CAV3 CAV3 CD24 CD24 PINK1 PINK1 PTGS2 PTGS2 TM9SF2L TM9SF2L RGCC RGCC VEGFA-1 VEGFA-1 BACH1 BACH1 TH TH MDM4 MDM4 PML PML CHRNA7 CHRNA7 ARNT2 ARNT2 ARNT ARNT NGB NGB SUV39H1 SUV39H1 EGLN1 EGLN1 FNDC1 FNDC1 FAM162A FAM162A DPP4-2 DPP4-2 NFE2L2 NFE2L2 LOXL3 LOXL3 TIGAR TIGAR NKX3-1-1 NKX3-1-1 NPEPPS NPEPPS BNIP3 BNIP3 KCNK2 KCNK2 TGFB2 TGFB2 SIRT1 SIRT1 DDIT4 DDIT4 PPARD PPARD EPAS1 EPAS1 PIN1 PIN1 P2RX3 P2RX3 DDR2-2 DDR2-2 FUNDC1 FUNDC1 SUV39H2 SUV39H2 LOXL4 LOXL4 EGLN3 EGLN3 SCFD1 SCFD1 SLC9A1 SLC9A1 P2RX2 P2RX2 AK4 AK4 Y1Q_0024190 Y1Q_0024190 THL THL SMAD4 SMAD4 PAM PAM SIRT2 SIRT2 GATA6 GATA6 CAV1 CAV1 NDNF NDNF Y1Q_0013170 Y1Q_0013170 AQP1 AQP1 EDNRA EDNRA STOX2 STOX2 VEGFC VEGFC RBPJ RBPJ CPEB2 CPEB2 FABP1 FABP1 NDRG1 NDRG1 MYOCD MYOCD Y1Q_0024039 Y1Q_0024039 HMOX1 HMOX1 Y1Q_0024068 Y1Q_0024068 CREBBP CREBBP HMOX2 HMOX2 MGARP MGARP CRYAB CRYAB OPRD1 OPRD1 Y1Q_0000967 Y1Q_0000967 PLAT PLAT TERT TERT WDR83 WDR83 LONP1 LONP1 ALKBH5 ALKBH5 TBL2 TBL2 LOXL3-2 LOXL3-2 SCAP SCAP ADAM17 ADAM17 WTIP WTIP NF1 NF1 PLEKHN1 PLEKHN1 HIF1A HIF1A MTOR MTOR NARF NARF CYGB CYGB HIF3A-1 HIF3A-1 NARFL NARFL EDN1 EDN1 PDK3-2 PDK3-2 FIGF FIGF MPL MPL GLTSCR2 GLTSCR2 Y1Q_0009747 Y1Q_0009747 HYOU1 HYOU1 TP53 TP53 XRCC1 XRCC1 USF1 USF1 ADO ADO Y1Q_0008457 Y1Q_0008457 REST REST Y1Q_0006972 Y1Q_0006972 TGFB3 TGFB3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PGF-1Placenta growth factor isoform A; Belongs to the PDGF/VEGF growth factor family. (219 aa)
CPEB1Cytoplasmic polyadenylation element-binding protein 1 isoform D. (595 aa)
HIF1ANHypoxia-inducible factor 1-alpha inhibitor. (394 aa)
VHLVon Hippel-Lindau disease tumor suppressor. (174 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
CD24CD24 molecule. (84 aa)
PINK1Serine/threonine-protein kinase PINK1, mitochondrial; Belongs to the arginase family. (851 aa)
PTGS2Prostaglandin G/H synthase 2. (605 aa)
TM9SF2LTransmembrane 9 superfamily member; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. (667 aa)
RGCCRegulator of cell cycle RGCC. (131 aa)
VEGFA-1Vascular endothelial growth factor A isoform A; Belongs to the PDGF/VEGF growth factor family. (216 aa)
BACH1Transcription regulator protein BACH1 isoform A. (665 aa)
THBH4_AAA_HYDROXYL_2 domain-containing protein. (531 aa)
MDM4Protein Mdm4. (513 aa)
PMLProtein PML isoform B. (586 aa)
CHRNA7Neuronal acetylcholine receptor subunit alpha-7. (502 aa)
ARNT2Uncharacterized protein. (749 aa)
ARNTAryl hydrocarbon receptor nuclear translocator isoform A. (785 aa)
NGBNeuroglobin; Belongs to the globin family. (180 aa)
SUV39H1Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (346 aa)
EGLN1Egl nine-like protein 1. (225 aa)
FNDC1Fibronectin type III domain-containing protein 1 isoform A. (948 aa)
FAM162AProtein FAM162A. (137 aa)
DPP4-2Uncharacterized protein; Belongs to the peptidase S9B family. (992 aa)
NFE2L2Nuclear factor erythroid 2-related factor 2. (482 aa)
LOXL3Lysyl oxidase-like protein 3. (775 aa)
TIGARFructose-2,6-bisphosphatase TIGAR. (272 aa)
NKX3-1-1Homeobox protein Nkx-3.1 isoform A. (238 aa)
NPEPPSAminopeptidase. (849 aa)
BNIP3BCL2/adenovirus E1B protein-interacting protein 3. (200 aa)
KCNK2Potassium channel subfamily K member 2; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (422 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (413 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1. (634 aa)
DDIT4DNA damage-inducible transcript 4 protein. (172 aa)
PPARDUncharacterized protein. (442 aa)
EPAS1Endothelial PAS domain-containing protein 1. (863 aa)
PIN1Peptidyl-prolyl cis-trans isomerase. (159 aa)
P2RX3P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (413 aa)
DDR2-2Uncharacterized protein. (857 aa)
FUNDC1FUN14 domain-containing protein 1. (156 aa)
SUV39H2Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (407 aa)
LOXL4Lysyl oxidase-like protein 4. (342 aa)
EGLN3Egl nine-like protein 3. (249 aa)
SCFD1Sec1 family domain-containing protein 1; Belongs to the STXBP/unc-18/SEC1 family. (632 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (802 aa)
P2RX2P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (464 aa)
AK4Adenylate kinase 4, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity. (223 aa)
Y1Q_0024190HATPase_c domain-containing protein. (755 aa)
THLTyrosine 3-monooxygenase-like. (463 aa)
SMAD4Mothers against decapentaplegic homolog. (559 aa)
PAMPeptidyl-glycine alpha-amidating monooxygenase isoform B. (871 aa)
SIRT2NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (392 aa)
GATA6Transcription factor GATA-6. (325 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
NDNFProtein NDNF. (578 aa)
Y1Q_0013170Uncharacterized protein. (100 aa)
AQP1Aquaporin-1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
EDNRAEndothelin-1 receptor; Belongs to the G-protein coupled receptor 1 family. (428 aa)
STOX2Storkhead-box protein 2. (306 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (414 aa)
RBPJRecombining binding protein suppressor of hairless isoform B. (498 aa)
CPEB2Uncharacterized protein. (495 aa)
FABP1Fatty acid-binding protein, liver. (127 aa)
NDRG1Protein NDRG1. (552 aa)
MYOCDMyocardin isoform A. (934 aa)
Y1Q_0024039KIX domain-containing protein. (131 aa)
HMOX1Heme oxygenase 1. (296 aa)
Y1Q_0024068Uncharacterized protein; Belongs to the complex I LYR family. (90 aa)
CREBBPCREB-binding protein isoform C. (2208 aa)
HMOX2Heme oxygenase 2. (408 aa)
MGARPProtein MGARP. (141 aa)
CRYABAlpha-crystallin B chain isoform A; Belongs to the small heat shock protein (HSP20) family. (174 aa)
OPRD1Delta-type opioid receptor; Belongs to the G-protein coupled receptor 1 family. (362 aa)
Y1Q_0000967Uncharacterized protein. (511 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (580 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (599 aa)
WDR83WD repeat domain-containing protein 83. (316 aa)
LONP1Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family. ECO:0000256|PROSITE-. (844 aa)
ALKBH5RNA demethylase ALKBH5. (379 aa)
TBL2Transducin beta-like protein 2. (441 aa)
LOXL3-2Uncharacterized protein. (513 aa)
SCAPSterol regulatory element-binding protein cleavage-activating protein. (1313 aa)
ADAM17Disintegrin and metalloproteinase domain-containing protein 17. (836 aa)
WTIPWilms tumor protein 1-interacting protein isoform A. (474 aa)
NF1Neurofibromin isoform B. (2879 aa)
PLEKHN1Pleckstrin-like proteiny domain-containing family N member 1. (707 aa)
HIF1AUncharacterized protein. (747 aa)
MTORSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2538 aa)
NARFNuclear prelamin A recognition factor; Belongs to the NARF family. (457 aa)
CYGBCytoglobin; Belongs to the globin family. (180 aa)
HIF3A-1Hypoxia-inducible factor 3-alpha isoform C. (374 aa)
NARFLCytosolic Fe-S cluster assembly factor NARFL; Belongs to the NARF family. (476 aa)
EDN1Endothelin-1. (200 aa)
PDK3-2Protein-serine/threonine kinase. (406 aa)
FIGFVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (353 aa)
MPLThrombopoietin receptor. (666 aa)
GLTSCR2Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (409 aa)
Y1Q_0009747Mothers against decapentaplegic homolog. (517 aa)
HYOU1Hypoxia up-regulated protein 1. (972 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa)
XRCC1DNA repair protein XRCC1-like. (608 aa)
USF1Upstream stimulatory factor 1 isoform B. (349 aa)
ADO2-aminoethanethiol dioxygenase. (166 aa)
Y1Q_0008457Nucleolar protein 3-like. (196 aa)
RESTRE1-silencing transcription factor. (913 aa)
Y1Q_0006972Uncharacterized protein. (555 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (415 aa)
Your Current Organism:
Alligator mississippiensis
NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator
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